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	题名	作者	年代	出处	被引量
1	Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats显示文摘AIM To design colon-targeted codrugs of mycophenolic acid(MPA) and aminosugars as a safer option to mycophenolate mofetil(MMF) in the management of inflammatory bowel disease. METHODS Codrugs were synthesized by coupling MPA with aminosugars(D-glucosamine and D-galactosamine) using EDCI coupling. The structures were confirmed by infrared radiation, nuclear magnetic resonance, mass spectroscopy and elemental analysis. The release profile of codrugs was extensively studied in aqueous buffers, upper gastrointestinal homogenates, faecal matter and caecal homogenates(in vitro) and rat blood(in vitro). Anti-colitic activity was assessed in 2,4,6-trinitrobezenesulfonic acid-induced colitis in Wistar rats by the estimation of various demarcating parameters. Statistical evaluation was performed by applying one-way and two-way ANOVA when compared with the disease control.RESULTS The prodrugs resisted activation in HCl buffer(pH 1.2) and stomach homogenates of rats with negligible hydrolysis in phosphate buffer(p H 7.4) and intestinal homogenates. Incubation with colon homogenates(in vitro) produced 76% to 89% release of MPA emphasizing colon-specific activation of codrugs and the release of MPA and aminosugars at the site of action. In the in vitro studies, the prodrug of MPA with D-glucosamine(MGLS) was selected which resulted in 68% release of MPA in blood. in vitro studies on MGLS revealed its colon-specific activation after a lag time of 8 h which could be ascribed to the hydrolytic action of N-acyl amidases found in the colon. The synthesized codrugs markedly diminished disease activity score and revived the disrupted architecture of the colon that was comparable to MMF but superior to MPA. CONCLUSION The significant attenuating effect of prodrugs and individual aminosugars on colonic inflammation proved that the rationale of the codrug approach is valid.	Shakuntala Santosh Chopade Suneela Sunil Dhaneshwar	2018	World Journal of Gastroenterology2018，24，10：	2
2	Biotyping of Acinetobacter cahoaceticus using the API 20NE system显示文摘	TOWNER K J CHOPADE B A	1987	Hosp Infect1987，10，2：	1
3	Recovery of dilute acetic acid through eaterification in a reactive distillation column显示文摘	Chopade S P Mahajani S M	2000	Catalysis Today2000，60，：	1
4	Acetalization of ethylene glycol with formaldehyde using cation-exchange resins as catalysts: Batch versus reactive distillation显示文摘	Shubham P Chopade Man Mohan Sharrna	1997	Reactive and Functional Poly- mers1997，34，1：	1
5	Propylene glycol and ethylene glycol recovery from aqueous solution via reactive distil-lation显示文摘	Dhale A D Myrant L K Chopade S P	2004	Chem Eng Sci2004，59，：	1
6	Bioemulsifier Production by Acinetobacter Strains Isolated from Healthy Human Skin 显示文摘	PATIL J R CHOPADE B A	2001	J Appl Microbiol2001，91，2：	1
7	Disposition and metabolism of p-nitroaniline in the male F-344 rat 显示文摘	CHOPADE H M MATTHEWS H B	1984	Toxicological Sciences1984，4，：	1
8	Unusual canal morphology in all mandibular incisors in a single patient显示文摘	Mattigatti S Mahaparale RR Chopade RV	2012	lnt J Dent Case Reports2012，2，3：	1
9	Recovery of dilute acetic acid through esterification in a reactive distillation column 显示文摘	SAHA B CHOPADE S P MAHAJANI S M	2000	Catalysis Today2000，60，12：	1
10	Recovery of dilute acetic acid through esterification in a reactive distillation column 显示文摘	Saha B Chopade S P Mahajani S M	2000	Catalysis Today2000，60，2：	1
11	Recovery of dilute acetic acid through esterification in a reactive distillation column显示文摘	Chopade S P Mahajani S M	2000	Catalysis Today2000，60，：	1
12	Isolation and characterization of indole acetic acid (IAA) pro- ducing Klebsiella pneumoniae strains from rhizosphere of wheat (Triticum aestivum) and their effect on plant growth显示文摘	Sachdev D P Chopade B A Kasture V M	2009	Indian Journal of Experimental Biology2009，47，12：	1
13	Study of functional properties of Sapindus mukorossi as a potential bio-surfactant显示文摘	GHAGI R SATPUTE S K CHOPADE B A	2011	Indian Journal of Science and Technology2011，4，5：	1
14	Recovery of dilute acetic acid through esterification in a reactive distillation column显示文摘	Saha B Chopade S E Mahajani S M	2000	Catalysis Today2000，60，1：	1
15	Recovery of dilute acetic acid through esterification in a reactive distillation column显示文摘	Saha B Chopade S P Mahajani S M	2000	Catalysis Today2000，60，2：	1
16	Study of functional properties o Sapindus mukorossi as a potential bio-surfactant显示文摘	GHAGI R SATPUTE S K CHOPADE B A	2011	Indian Journal of Science and Technology2011，4，5：	1
17	Recovery of dilute acetic acid through esterification in a reactive distillation column显示文摘	Saha B Chopade S P Mahajani S M	2000	Catalysis Today2000，60，2：	1
18	Comment on“supracostal approach in percutaneous nephrolithotomy: experience of 102 cases”显示文摘	Maheshwari PN Chopade DK Andankar MG	2003	J Endourol2003，17，：	1
19	Biotyping of Acinetobacter calcoaceticus using the API 20NE system显示文摘	Towner K J Chopade B A	1987	Hosp Infect1987，10，2：	1
20	Analysis of discrete wavelet based image compression technique: a review显示文摘	CHOPADE N B GHATOL A A	2009	Journal of Scientific & Industrial Research2009，68，11：	1

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