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| 1 | Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein显示文摘Beclin 1 基因是 haplo 不够的肿瘤 suppressor 并且在 autophagy 起一个必要作用。然而, Beclin 1 由工作的分子的机制仍然保持大部分未知。这里,我们在 1.6 Å 报导 Beclin 1 的 evolutionarily 保存的领域(ECD ) 的水晶结构;分辨率。Beclin 1 ECD 展览一以前 unreported 褶层,与在中央轴附近相称性地安排的三次结构的重复。Beclin 1 ECD 定义膜绑定领域的一个新奇的类,与为与 cardiolipin 充实的类脂化合物膜的强壮的偏爱。在 Beclin 1 ECD 的一个表面环的尖端,包括三芳香的氨基酸,与类脂化合物膜充当一根恐水病的手指到伙伴,因而导致膜和 liposomes 的变丑。这些芳香的残余的变化使 Beclin 1 变为不能稳定地在 vitro 与类脂化合物膜联系并且不能充分在 vivo 在 Beclin 1-knockdown 房间救 autophagy。这些观察为译解形成一个重要框架 Beclin 1 的生物功能。 | Weljlao Huang Wooyoung Chol Wanqiu Hu Na Mi Qiang Guo Meisheng Ma Mei Liu Yuan Tian Peilong Lu Feng-Liang Wang Haiteng Deng Lei Liu Ning Gao Li Yu Yigong Shi | 2012 | Cell Research2012，22，3： | 21 |
| 2 | Intrahepatic biliary cystadenoma:Is there really an almost exclusively female predominance?显示文摘Biliary cystic tumors,such as cystadenomas and cystadenocarcinomas,are rare cystic tumors of the liver,accounting for less than 5% of all intrahepatic cysts of biliary origin.Biliary cystadenomas have been known to occur predominantly in women (> 85%),and 38%-44% of biliary cystadenocarcinomas have occurred in males.We wrote this letter to comment on a brief article (World J Gasteroenterol 2011 January 21;17(3):361-365) regarding a case of intrahepatic biliary cystic neoplasm treated with surgery.The adenoma-carcinoma sequence is the possible mechanism of carcinogenesis.If the carcinogenesis of biliary cystadenocarcinoma occurs in the adenoma-carcinoma sequence,we believe that the male-to-female ratio of cystadenoma should be higher than the incidence rate that has been reported to date. | Ho Hyun Kim Young Hoe Hur Yang Seok Koh Chol Kyoon Cho Jin Woong Kim | 2011 | World Journal of Gastroenterology2011，17，25： | 12 |
| 3 | Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult显示文摘BACKGROUND:Undifferentiated embryonal sarcoma (UES) of the liver is a rare,highly malignant neoplasm with a poor prognosis occurring almost exclusively in late childhood (6-10 years of age).Only a few cases have been reported in adults accounting for less than 1% of all primary liver neoplasms.METHODS:A 47-year-old woman presented with a palpable mass in the left upper abdomen.Magnetic resonance imaging revealed a 12×10 cm cystic mass with hemorrhage in the left lateral segment of the liver.The initial impression was a hemorrhagic cystic tumor of the liver.The patient underwent a left lateral sectionectomy of the liver.Histopathology and immunohistochemistry helped make a diagnosis of UES.RESULTS:The patient recovered uneventfully and received systemic chemotherapy.Radiologic examination for follow-up revealed a metastatic lesion in the lumbar spine (L5).She was subjected to radiotherapy at the lumbar spine.She survived 48 months.CONCLUSION:Although hepatic cyst as UES of the liver is difficult to diagnose because of its rarity in adults and lack of specific findings,it should be considered in a differential diagnosis. | Ho Hyun Kim Jung Chul Kim Eun Kyu Park Young Hoe Hur Yang Seok Koh Chol Kyoon Cho Hyung Seok Kim Hyun Jong Kim | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 6 |
| 4 | 韩国低危前列腺癌患者的分级和分期的升高:一项多中心研究显示文摘与美国82%的局限性前列腺癌发病率相比,韩国局限性前列腺癌病例仅为54%。此外,在根治性前列腺切除后,半数韩国患者的肿瘤分级提高。我们研究了低危前列腺癌患者在根治性前列腺切除后分级和/或分期升高的危险因素。我们回顾性性分析了Honam省5家医院1159例接受根治性前列腺切除的患者的医学记录。收集了术前的标准临床病理学参数,根治性前列腺切除的标本给予分级和分期,我们把“预后不佳”定义为Gleason 评分大于等于7,或病理分期大于等于T3。应用多元回归模型分析评价术后病理分期提高的相关因素。在1159例患者中,324例归类为临床低危组,154例(47.5%)患者既有分级的提高也有分期的提高。多变量分析显示,术前血清前列腺抗原水平(odds ratio [OR], 1.131; 95%confidence interval [CI], 1.007-1.271; P= 0.037), 穿刺组织的肿瘤阳性百分率 (OR: 1.018; 95% CI: 1.002-1.035; P= 0.032),和小前列腺体积(〈30ml)(OR: 2.280; 95% CI: 1.351-3.848; P=0.002)是不良预后的预测指标。总体讲,47.5%的低危患者术后分期增加。对于我们的研究组,目前的危险度分级标准可能过于宽松。 | Insang Hwang Donghoon Lim Young Beom Jeong Seung Chol Park Jun Hwa Noh Dong Deuk Kwon Taek Won Kang | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 5 | Boundedness of θ-type Calderon-Zygmund operators on non-homogeneous metric measure space显示文摘 | Chol RI Zhenqiu ZHANG | 2016 | Frontiers of Mathematics in China2016，11，1： | 2 |
| 6 | 内镜颅底外科带血管蒂黏膜瓣技术的研究进展显示文摘经鼻内镜颅底外科因微创的手术入路、术中肿瘤暴露充分、全切除率高、术后恢复快、住院时间短等优势越来越受到颅底外科医师的青睐。在过去的10年中,经鼻内镜颅底入路相关解剖的深入研究以及内镜器械和影像学技术的发展极大地改善了颅底腹侧及硬膜内病变的暴露与切除[1-2]。颅底重建是此类手术最关键的步骤之一,关系手术成败。在黏膜瓣技术被引入内镜颅底修补术之前, | 刘腾飞 RI CHOL JU 顾晔 张晓彪 | 2016 | 中国临床医学2016，23，2： | 2 |
| 7 | 韩国青少年心理健康问题研究显示文摘日常生活中的科学进步与生活水平的提高不但提高了生活满意度,而且降低了多种疾病的发病率。然而,对青少年不利的周边环境和过于注重升学率的教育系统威胁到了当今韩国青少年的心理健康的成长与发展。本研究的目的在于:尝试弄清韩国青少年心理健康的现状,在此基础上制定措施来改善现状。 | In Jae Chol 石雪 | 2013 | 上海青年管理干部学院学报2013，，2： | 2 |
| 8 | Structural and Magnetic Properties of Nanocomposite Nd Fe BPrepared by Rapid Thermal Processing显示文摘Nanoscale permanent magnetic materials,which possess excellent magnetic and mechanical properties,thermal stability,and corrosion resistance,have become a research hotspot for permanent magnets.In reality,however,the obtained maximum energy product,(BH)max,is not satisfactory in comparison with the theory limit,especially for exchange-coupled nanocomposite magnets.The construction of an ideal microstructure still remains a challenge in the synthesis and preparation of nanoscale permanent magnets.This work reported the impact of rapid thermal process(RTP)with electron-beam heating on the microstructures of Nd12.5-xFe80.8+xB6.2Nb0.2Ga0.3(x=0,2.5)nanocomposites.It was found that the crystallization time was greatly reduced,from 15 min under the conventional annealing conditions to 0.1 s under the RTP.For Nd2Fe14B single-phase materials,the crystallization temperature of the RTP ribbons decreased by about 248 C compared with that of the ribbons produced by the conventional annealing method.A synergetic crystallization of the Nd2Fe14B and a-Fe phases was observed under the RTP,which restrained not only the shape,size distribution,and compositions of the hard and the soft phases,but also the interface between them.This modification effect became more obvious as the fraction of Fe increased.Due to the improvement in the uniformity of the Nd2Fe14B and a-Fe phases,and their grain size distribution,better magnetic properties were achieved using RTP in comparison with the conventional annealing method. | Jinbo Yang Jingzhi Han Haidong Tian Liang Zha Xiongzuo Zhang Chol Song Kim Dong Liang Wenyun Yang Shunquan Liu Changsheng Wang | 2020 | Engineering2020，6，2： | 2 |
| 9 | Confined Concrete-Filled Tubular Columns 显示文摘 | Xiao Y He W Chol K | 2005 | Journal of Structure Engineering ASCE2005，131，： | 1 |
| 10 | A randomized intervention of mon- telukast for post-bronchiolitis:Effect on eosinophil degranulation 显示文摘 | Kim CK Chol J Kim HB | 2010 | J Pediatr2010，156，5： | 1 |
| 11 | Flow control around a circular cylinder using plused dielectric barrier discharge surface plasma显示文摘 | Timothy N Jukes Kwing So Chol | 2009 | Physics of Fluid2009，21，8： | 1 |
| 12 | 显示文摘 | Hoffmann M R Martin S T Chol W Y | 1995 | Chemical Reviews1995，95，： | 1 |
| 13 | Foxdl-dependent signals control cellularity in the renal capsule, a structure required for normal renal development 显示文摘 | Levinson RS Batourina E Chol C | 2005 | Development2005，132，2： | 1 |
| 14 | Renal cell apoptosis in chronic obstructive uropathy: the roles of easpases 显示文摘 | Truong LD Chol YJ Tsao CC | 2001 | Kidney Int2001，60，： | 1 |
| 15 | Effect of humus soil on the settling and dewatering characteristics of activated sludge 显示文摘 | CHOL Y G CHUNG T H | 2000 | Water Science and Technology2000，42，9： | 1 |
| 16 | A prospective trial comparing tension-free vaginal tape and transobturator vaginal tape inside-out for the surgical treatment of female stress urinary incontinence: l-year follow up 显示文摘 | Lee KS Hall DH Chol YS | 2007 | J Urol2007，177，： | 1 |
| 17 | Local bond of deformed bars with different diameters in confined concrete显示文摘 | Soroushian P Chol K | 1989 | ACI Struct J1989，86，2： | 1 |
| 18 | Hyperbaric Spinal Ropivacaine for Cesarean Delivery: A Comparison to Hyperbaric Bupivacaine显示文摘 | Chung CJ Chol SR Yeo KH | 2001 | Anesth Analg2001，93，： | 1 |
| 19 | Four new diarylheptanoids from the roots of Juglans mandshurica 显示文摘 | Li G Xu M L Chol H C | 2003 | Chem Pharm Bull2003，51，3： | 1 |
| 20 | Role of high glucoseinduced nuclear factor-κB activation in monocyte chemoattractant peptide-1 expression by mesangial cells 显示文摘 | Ha H Yu MR Chol YJ | 2002 | J Am Soc Nephrol2002，13，： | 1 |
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