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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Bowel wall thickening in patients with Crohn's disease: CT patterns and correlation with inflammatory activity显示文摘 | Choi D Jin LS Ah CY | 2003 | Clin Radiol2003，58，： | 1 |
| 3 | Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze 显示文摘 | Choi LS Byeon JH Yoo Y | 2009 | Pediatr Pulmonol2009，44，5： | 1 |
| 4 | Bowel wall thickening in pa tients with Crohn's disease: CT patterns and correlation with inflammatory activity 显示文摘 | Choi D Jin LS Ah CY | 2003 | Clin Radiol2003，58，： | 1 |
| 5 | Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze显示文摘 | Choi LS Byeon JH Yoo Y | 2009 | Pediatr Pulmonol2009，44，5： | 1 |
| 6 | Factors affecting rotator cuffhealing显示文摘 | Mall NA Tanaka MJ Choi LS | 2014 | J Bone Joint Surg Am2014，96，9： | 1 |
| 7 | Phase H study of pem-etrexed plus carboplatin, or pemetrexed plus cisplatin with concur-rent radiation therpy followed by pemetrexed consolidation in patientswith favorable-prognosis inoperable stage EQ A/B non-small-cell lungcancer显示文摘 | Choy H Schwartzberg LS Dakhil SR | 2013 | J Thorac 0ncol2013，8，10： | 1 |
| 8 | Primary non-Hodgkin's lymphoma of bone in children显示文摘 | Glotzbecker MP Kersun LS Choi JK | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 9 | Breast cancer cells induce osteolytic bone lesions in vivo through a reduction in osteoblast activity in mice显示文摘 | Gregory LS Choi W Burke L | 2013 | PLoS One2013，8，68： | 1 |
| 10 | Bowel wall thickening in patients with Crohn's disease:CT patterns and correlation with inflammatory activity显示文摘 | Choi D Jin LS Ah CY | 2003 | Clin Radiol2003，58，： | 1 |
| 11 | Defective urinaryconcentrating ability due to a complete deficiency of aquaporin-1 显示文摘 | KING LS CHOI M FERNANDEZ PC | 2001 | N Engl J Med2001，345，3： | 1 |
| 12 | Defective urinary concentrating ability due to a complete deficiency of aquaporin-1 显示文摘 | KING LS CHOI M FERNANDEZ PC | 2001 | N Engl J Med2001，345，3： | 1 |
| 13 | Low expression of p27 (kipl) in advanced mucoepidermoid carcinoma of head and neck显示文摘 | Choi LS Choi G Jung KY | 2001 | Head Neck2001，23，： | 1 |
| 14 | Factors affecting rotator cuff healing显示文摘 | Mall NA Tanaka MJ Choi LS | 2014 | J Bone Joint Surg Am2014，96，9： | 1 |
| 15 | Translation and validation of the Hong Kong Chinese version the breastfeeding self-efficacy scale-short form显示文摘 | Ip WY Yeung LS Choi KC | 2012 | Res Nurs Health2012，35，5： | 1 |
| 16 | Seizures in alzhei- mer disease: who, when, and how common? 显示文摘 | Scarmeas N Honig LS Choi H | 2009 | Arch Neurol2009，66，8： | 1 |
| 17 | Increased serum inter- leukin-5 and vascular endothelial growth factor in chil- dren with acute mycoplasma pneumonia and wheeze显示文摘 | Choi LS Byeon JH Yoo Y | 2009 | Pediatr Pulmonol2009，44，5： | 1 |
| 18 | A3 adenosine receptor antagonist, truncated Thio- CI-IB-MECA, induces apoptosis in T24 human bladder cancer cells 显示文摘 | Kim H Kang JW Lee S Choi WJ Jeong LS Yang Y | 2010 | Anticancer Res2010，30，7： | 1 |
| 19 | Comparison of hand- sewn, linear-stapled, and circular-stapled gastrojejunostomy in laparoscopic Roux-en-Y gastric bypass显示文摘 | Bendewald FP Choi JN Blythe LS et ai | 2011 | Obesity surgery2011，21，11： | 1 |
| 20 | Primary nonHodgkin's lympboma of bone in children显示文摘 | Glotzbecker MP Kersun LS Choi JK | 2006 | J Bone Joint Surg Am2006，88，3： | 1 |
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