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	题名	作者	年代	出处	被引量
1	MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs.	Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho	2018	World Journal of Gastroenterology2018，24，27：	29
2	Early treatment outcome of isolated calf vein thrombosis after total knee arthroplasty显示文摘	Yun WS Lee KK Cho J	2012	J Korean Surg Soc2012，82，6：	1
3	Inflammatory mediators induced by intratracheal instillation of ultrafine amorphous silica particles 显示文摘	Cho WS Choi M Han BS	2007	Toxicol Lett2007，175，123：	1
4	Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues显示文摘	Ha TS Jeong SY Cho SW Jeon HK Roh GS Choi WS Park CS		0，，：	1
5	Acute toxicity and pharmacokinetics of 13 nm-sizedPEG-coated gold nanoparticles显示文摘	Cho WS Cho M Jeong J Choi M Cho HY Han BS etal	2009	Toxicol Appl Pharma-col2009，236，1：	1
6	Nocardia brain ab- scess in a liver transplant recipient 显示文摘	Moon JH Cho WS Kang HS Kim JE	2011	J Korean Neurosurg Soc2011，50，4：	1
7	Gets Sensing Properties of Printed MultiwaUed Carbon Nanotubes Using the Field Emission Effect显示文摘	Lee YD Cho WS Moon SI	2006	Chemical Physics Letters2006，433，：	1
8	Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles显示文摘	Cho WS Cho M Jeong J	2009	Toxicol Appl Pharmacol2009，236，1：	1
9	A critical role for the histidine residues in the catalytic function of acyl-CoA: cholesterol acyltransferase catalysis: evidence for catalytic difference between ACAT1 and ACAT2 显示文摘	An S Cho KH Lee WS	2006	FEBS Lett2006，580，11：	1
10	Treatment of burn scar using a carbon dioxide fractional laser显示文摘	Cho SB Lee SJ Chung WS	2010	J Drugs Dermatol2010，9，2：	1
11	The spectrum of Epstein-Barr virus-associated lymphoproliferative disease in Korea:incidence of disease entities by age groups显示文摘	Cho EY Kim KH Kim WS	2008	J Korean Med Sci2008，23，2：	1
12	The spectrum of Epstein-Barr virus associated lymphoproliferative disease in Korea:Incidence of disease entities by age groups显示文摘	Cho EY Kim KH Kim WS	2008	J Korean Med Sci2008，23，2：	1
13	Comparative evaluation of brain CT and ELISA in the diagnosis of neurocysticercosis显示文摘	Chang KH Kim WS Cho SY	2008	AJNR2008，，9：	1
14	Omega-3 fatty acid supple- mentation attenuates oxidative stress, inflammation, and tubU- lointemtitial fibrosis in the remnant kidney 显示文摘	An WS Kim HJ Cho KH	2009	Am J Physiol Renal Physiol2009，297，4：	1
15	Hypermethylation of the RUNX3 gene in hepatocellular carcinoma显示文摘	Park WS Cho YG Kim CJ	2005	Exp Mol Med2005，37，4：	1
16	17beta-estradiol pretreatment prevents the global ischemic injury-induced decrease of Akt activation and bad phosphorylation in gerbils显示文摘	Koh PO Cho GJ Choi WS	2006	J Vet Med Sci2006，68，10：	1
17	What have we learn- ed from LCS mobile-bearing knee system? 显示文摘	Cho WS Youm YS Ahn SC	2010	Knee Surg Sports Traumatol Arthrosc2010，18，10：	1
18	Effect of Gui - zhi - fu - ling - wan on hot flashes in young patients: a retrospective case series 显示文摘	Cho KH Kim YS Jung WS	2011	J Aeupunct Meridian Stud2011，4，2：	1
19	Different radiological findings with the same pathologic diagnosis due to different age in primary osteosarcoma 显示文摘	Lee SY Cho WH Song WS Park JH	2006	Acta Radiol2006，47，8：	1
20	Ezrin expression predicts survival in stageⅡb osteosarcomas显示文摘	Kim MS Song WS Cho WH	2007	Clin Orthop Relat Res2007，459，7：	1

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