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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 3 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 4 | Effectof mobile phase composition on the separation of propranolol enantiomers using a perphenylcarbamate β-cyclodextrin bonded chiral stationary phase显示文摘 | CHING C B FU P N G SC | 2000 | J Chromatogr A2000，898，： | 2 |
| 5 | IFN-beta-dependent inhibition of tumor growth by the vascular disrupting agent 5, 6-dimethylxanthe- none-d-acetic acid (DMXAA) 显示文摘 | Roberts Z J Ching L M Vogel S N | 2008 | J Interferon Cytokine Res2008，28，3： | 1 |
| 6 | Magnetic structure and Fe moment distribution in rare-earth iron intermetallic compounds by first-principles calculations 显示文摘 | Ching W Y Xu Y N | 2000 | J Magn Magn Mate2000，209，： | 1 |
| 7 | A review of muhiehannel indices of class separability 显示文摘 | THOMAS I L CHING N P BENNING V M | 1987 | International Journal of Remote Sensing1987，8，： | 1 |
| 8 | A one-year trial of lamivudine for chromic hepatitisB显示文摘 | CHING LL RONG NC leung N | 1998 | New Engl J Med1998，339，9： | 1 |
| 9 | An accurate power control strategy for power electronics interfaced distributed generation units operating in a low voltage multibus microgrid 显示文摘 | Li Y W Ching N K | 2009 | IEEE Transactions on Power Electronics2009，24，12： | 1 |
| 10 | Grain boundary strengthening in alumina by rare earth impurities显示文摘 | BUBAN J P MATSUNAGA K CHEN J SHIBATA N CHING W Y IKUHARA Y | 2006 | Science2006，311，5758： | 1 |
| 11 | Attitudes towards termi- nation of pregnancy among Hong Kong Chinese women attending prenak tal diagnosis counselling clinic显示文摘 | Leung T N Ching Chau M M Chang J J | 2004 | Prenat Diagn2004，24，7： | 1 |
| 12 | A lasermicromachined multi - modal resonating power transducer for wireless sensing systems 显示文摘 | Ching Neil N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 13 | 显示文摘 | Ching W Y Yong N X Rulis P | 2002 | Appl Phys Lett2002，80，： | 1 |
| 14 | A laser-micromachined multi-modal resonating power transducer for wireless sensing systems显示文摘 | Ching N N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
| 15 | Electronic,optical,and structuralproperties of some wurtzite crystals显示文摘 | XU Y N CHING W Y | 1993 | Physical Review B1993，48，7： | 1 |
| 16 | Sol-gel route to the tunneled manganese oxide cryptomelane 显示文摘 | Ching S Roark J L Duan N | 1997 | Chem Ma- ter1997，9，3： | 1 |
| 17 | The use of growth factor and other humoral agents to accelerate and enhance burn wound healing显示文摘 | Ching H Y Sutton T L Pierpont Y N | 2011 | Eplasty2011，11，： | 1 |
| 18 | Strategies for improving the efficiency of semiconductor metal oxide photocatalysis 显示文摘 | Djurisic A B Leung Y H Ching N A M | 2014 | Materials Horizons2014，，4： | 1 |
| 19 | Kidney tumor location measurement using the C index method显示文摘 | Simmons M N Ching C B Samplaski M K | 2010 | J Urol2010，183，5： | 1 |
| 20 | Iterative algorithms based on decoupling of deblurring and denoising for image restoration显示文摘 | Wen Y W Michael K N and Ching W K | 2008 | SIAM Journal on Scientific Computing2008，30，5： | 1 |
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