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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 3 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 4 | Episodic evolution of growth hormone in primates and emergence of the species specificity of human growth hormone receptor显示文摘 | Jaw- Ching Liu Kateryna D Makova Ronald M Adkins | 2001 | Mol Biol Evol2001，，18： | 1 |
| 5 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 6 | Oxidative degradation of 2, 4, 6-Trinitrotoluene by ozone in an electrohydraulic discharge reactor显示文摘 | Lang P S Ching W K Willberg D M | 1998 | Environ Sci Technol1998，32，20： | 1 |
| 7 | Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis显示文摘 | Li K Ching D Luk FS | 2015 | Cire Res2015，117，1： | 1 |
| 8 | Electronic Structure of Normal, Inverse,and Partially Inverse Spinels in the MgAl2O4 System 显示文摘 | Mo S D Ching W Y | 1996 | Phys Rev B1996，54，16： | 1 |
| 9 | Influence of annealing on the microstructural, tensile and fracture properties of Polypropylene films显示文摘 | FERRER-BALAS D MASPOCH M L MARTINEZ A B CHING E MAI Y W | 2001 | Polymer2001，42，： | 1 |
| 10 | Fluid flow and heat transfer model for high-speed rotating heat pipes 显示文摘 | Song F Ching C Y Ewing D | 2003 | International Journal of Heat and Mass Transfer2003，46，23： | 1 |
| 11 | Review Article A review of multi-channel indices of class separability显示文摘 | I. L. Thomas N. P. Ching V. M. Benning J. A. D’Aguanno | 1987 | International Journal of Remote Sensing1987，，3： | 1 |
| 12 | Interesting Physical Properties of the New Spinel Phase of Si3N4 and C3N4显示文摘 | Mo S D Ouyang L Z Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 13 | Counter-current and simulated counter-current adsorption separation processes显示文摘 | Ching C B | 1989 | Chemical Engineering Science1989，44，5： | 1 |
| 14 | Electronic and optical properties of three phases of titanium dioxide: rutile, anatase, and brookite显示文摘 | MO S D CHING W Y | 1995 | Physical Review B1995，51，13： | 1 |
| 15 | Counter-current and simulated counter-current adsorption separation processes显示文摘 | Ruthven D M Ching C B | 1989 | Chemical Engineering Science1989，44，5： | 1 |
| 16 | Tracking rapidly changing dynamical systems using a non - parametric statistical method based on wavelets显示文摘 | Ching J Y Glaser S D | 2003 | Earthquake Engineering and Structural Dynamics2003，，32： | 1 |
| 17 | Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway显示文摘 | Ching C B Hansel D E | 2010 | Lab Invest2010，90，10： | 1 |
| 18 | Apolipoprotein E Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor- KB-Driven Inflammation and Atherosclerosis显示文摘 | Li K Ching D Luk FS | 2015 | Circ Res2015，117，1： | 1 |
| 19 | Effect of number of mesh layers and fluid loading on the performance of screen mesh wicked heat pipes 显示文摘 | Kempers R Ewing D Ching C Y | 2006 | Applied Thermal Engineering2006，26，： | 1 |
| 20 | Multi scale modeling of grouted sand behavior显示文摘 | Pierre Yves H Ching S C Christophe D | | 0，，： | 1 |
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