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| 1 | A truth serum for cancer -- microRNAs have major potential as cancer biomarkers显示文摘 | Lena J Chin Frank J Slack | 2008 | Cell Research2008，18，10： | 39 |
| 2 | The^(40)Ar/^(39)Ar age record of formation and uplift of the blueschists and eclogites in the western Tianshan Mountains显示文摘The 40Ar/39Ar ages indicate that the eclogite facies rocks of the Hasiate slice in the western Tianshan Mountains were formed at the early stage of Devonian (401 Ma) and had been uplifted to the greenschist facies tectonic level in the middle stage of Devonian (381 Ma). The formation and uplift of the blueschists of the Akesayi slice are constrained to the late stage of Devonian (370-364 Ma). The different tectonic slices in the high-pressure metamorphic belt have experienced the different uplift history. | GAO Jun, ZHANG Lifei & LIU Shengwei1. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 2. Department of Geology, Peking University, Beijing 100871, Chin | 2000 | Chinese Science Bulletin2000，45，11： | 35 |
| 3 | Cross-kingdom inhibition of breast cancer growth by plant miR159显示文摘MicroRNAs (miRNAs ) 是基因表示的批评管理者,并且在优核质的开发,生理学,和疾病施加广泛的影响。并行的高度在植物和动物在 miRNA 生物的续生说和行动的分子的基础被发现。最近的研究有趣地建议导出植物的 miRNAs 的一个潜在的跨王国的行动,通过饮食的吸入,在调整哺乳动物的基因表示。尽管在哺乳动物的标本检测的植物 miRNAs 的来源和范围仍然保持争论,这些起始的研究鼓舞了我们决定植物 miRNAs 是否能在西方的人的 sera 被检测并且这些植物 miRNAs 是否能影响与象癌症那样的人的疾病有关的基因表示和细胞的过程。这里,我们发现西方的施主 sera 包含了植物 miRNA miR159,其在浆液的丰富相反地在病人与乳癌发生和前进被相关。在人的 sera, miR159 主要在细胞外的泡被检测,并且对在 3 ′ 上建议发源植物的 2'-O-methylation 的钠 periodate 氧化抵抗;终端核糖。在乳癌房间然而并非非癌的乳房的上皮的房间,一合成 miR159 模仿能够由指向编码表明抄写因素的 Wnt 的 TCF7 禁止增长,在 MYC 蛋白质层次导致减少。miR159 的口头的管理显著地模仿在老鼠压制了异种皮移植胸肿瘤的生长。这些结果第一次证明植物 miRNA 能在哺乳动物禁止癌症生长。 | Andrew R Chin Miranda Y Fong George Somlo Jun Wu Piotr Swiderski Xiwei Wu Shizhen Emily Wang | 2016 | Cell Research2016，26，2： | 35 |
| 4 | An Eperimental Study on the Transplantation of Human Fetal Brain Cells into Monkey Models of Parkinson's Disease.显示文摘Unilateral administration of methly-phenyl-tetrahydropyridine(MPTP) into the common carotid | Liu Zhengou, et al. Dept Neur Ruijin, Hospital. Shanghai Second Med Uni, Shanghai 200025, Chin J Neuro Psych 1994 | 1995 | Chinese Medical Journal1995，，2： | 34 |
| 5 | Optoelectronic devices based on two-dimensional transition metal dichalcogenides显示文摘在过去几年里,二维(2D ) 转变金属 dichalcogenide (TMDC ) 材料吸引了研究社区的增加的注意由于他们的唯一的电子、光的性质,从当放大材料从时,联合到 indirect-to-direct bandgap 转变的山谷纺纱对单层多层。这些性质在通讯,计算,和保健的宽广领域里用重要应用正在恳求电子的小说和 optoelectronic 设备的发展。当材料厚度减少从时, TMDC 家庭的特色之一是发生的 indirect-to-direct bandgap 转变对单层多层,它为许多 photonic 应用是有利的。TMDC 也为与对他们也没有格子失配问题的层厚度的原子水平的控制构造大量 heterostructures 表明了崭新的灵活性和通用性。作为结果,在有另外的 2D 材料的联合的分层的 TMDC 为在宽广操作上认识到新奇高效的 optoelectronic 设备有潜力光谱范围。在这篇文章,我们在 2D TMDC 和 optoelectronic 设备研究的合成考察最近的进步。我们也讨论面对 2D 材料的家庭的可伸缩的应用的挑战并且在这些材料为 nanophotonics 技术的未来代提供的机会上提供我们的观点。 | He Tian Matthew L. Chin Sina Najmaei Qiushi Guo Fengnian Xia Hart Wang Madan Dubey | 2016 | Nano Research2016，9，6： | 22 |
| 6 | Fiber and prebiotic supplementation in enteral nutrition:A systematic review and meta-analysis显示文摘AIM:To investigate fiber and prebiotic supplementation of enteral nutrition(EN) for diarrhea,fecal microbiota and short-chain fatty acids(SCFAs).METHODS:MEDLINE,EMBASE,Cochrane Library,CINAHL,Academic Search Premier,and Web of Science databases were searched for human experimental and observational cohort studies conducted between January 1990 and June 2014.The keywords used for the literature search were fiber,prebiotics and enteral nutrition.English language studies with adult patient populations on exclusive EN were selected.Abstracts and/or full texts of selected studies were reviewed and agreed upon by two independent researchers for inclusion in the meta-analysis.Tools used for the quality assessment were Jadad Scale and the Scottish Intercollegiate Guidelines Network Critical Appraisal of the Medical Literature.RESULTS:A total of 456 possible articles were retrieved,and 430 were excluded due to lack of appropriate data.Of the 26 remaining studies,only eight investigated the effects of prebiotics.Results of the meta-analysis indicated that overall,fiber reduces diarrhea in patients receiving EN(OR = 0.47;95%CI:0.29-0.77;P = 0.02).Subgroup analysis revealed a positive effect of fiber supplementation in EN towards diarrhea in stable patients(OR = 0.31;95%CI:0.19-0.51;P < 0.01),but not in critically ill patients(OR = 0.89;95%CI:0.41-1.92;P = 0.77).Prebiotic supplementation in EN does not improve the incidence of diarrhea despite its manipulative effect on bifidobacteria concentrations and SCFA in healthy humans.In addition,the effect of fiber and/or prebiotic supplementation towards fecal microbiota and SCFA remain disputable.CONCLUSION:Fiber helps minimize diarrhea in patients receiving EN,particularly in non-critically ill patients.However,the effect of prebiotics in moderating diarrhea is inconclusive. | Mazuin Kamarul Zaman Kin-Fah Chin Vineya Rai Hazreen Abdul Majid | 2015 | World Journal of Gastroenterology2015，21，17： | 18 |
| 7 | Management of patients with stercoral perforation of the sigmoid colon:Report of five cases显示文摘到我们的知识,冒号的粪的穿孔很少比 90 个案例在文学报导到日期为止与少数被看见。我们探索了管理的原则与这个条件在五个病人阻止逼近的死亡。五个病人,二男性和三女性,其中部的年龄是 64 年,支撑了 S 字形的冒号的粪的穿孔。长期的便秘是在这些病人之中的普通症状。三个病人经历了一个 Hartmannos 过程和另外一个二与吻合和转移结肠开口术与部分结肠切除术被对待。有一外科的死亡,另外的病人让一所平静医院留下来。与广泛的腹洗室年龄一起阻止或对待任何联系败血的及时干预和在主要粪的溃疡地点的结肠的织物结合了移开 diseased 的外科的干预为腹膜炎的好攻击的治疗是在抢救与冒号的粪的穿孔介绍的病人的关键治疗形式。 | Wen-Shih Huang Chia-Siu Wang Ching-Chuan Hsieh Paul Y Lin Chih-Chien Chin Jeng-Yi Wang | 2006 | World Journal of Gastroenterology2006，12，3： | 18 |
| 8 | 基于QFD和前景理论的产品规划方案选择方法显示文摘为了以有效的方式反映决策者的心理和行为特征,提出基于不确定语言信息熵和前景理论的产品规划方案选择方法。客户代表使用不确定语言变量表征本企业及竞争对手产品的竞争性,利用信息熵的方法确定各项客户需求项目的竞争优先次序,据此得出产品规划的备选方案;引入前景理论的思想,依据备选方案的投入成本,计算各个方案的成本感知价值;再次,计算不同风险场景和盈利场景的价值和权重,确定各个方案的风险感知价值和盈利感知价值;依据成本感知价值、风险感知价值和盈利感知价值,确定各个备选方案的综合感知价值,并据此得到产品规划的最优方案。以PE破碎机的改进为例,说明了所提方法的实用性和可靠性。 | 王增强 李延来 蒲云 CHIN K S | 2013 | 机械工程学报2013，49，4： | 18 |
| 9 | Vibrational characteristics of piping system in air conditioning outdoor unit显示文摘The modal analysis of piping system in air conditioner (AC) outdoor unit is essential to investigate the vibration properties of the system. In view of the growing significance of numerical finite element (FE) model for vibration behaviour prediction, the AC piping elastic end support characterization has been explored. The axial and radial stiffness variables (ka, kr1, kr2) of the compressor-piping mounting are obtained and represented by dynamic stiffness of compressor grommet. They are obtained from dynamic load deflection test based on compressor operating condition such as excitation frequency and amplitude. The unknown stiffness variables of the other tube end (chassis-piping mounting) are determined by parameter fine tuning. An experimental modal analysis using impact hammer test has also been employed to determine the vibration properties such as natural frequencies, mode shapes and damping ratio of the piping structures. The modal parameters acquisition using SCADAS mobile acquisition system and LMS Impact Testing software is compared with the corresponding simulated modal properties using Abaqus. Most of the simulated natural frequencies achieve good correlation with the measured frequencies and it is reasonably a good prediction model to predict vibration behaviour of AC piping structures. | S. K. LOH W. F. FARIS M. HAMDI W. M. CHIN | 2011 | Science China(Technological Sciences)2011，54，5： | 17 |
| 10 | LITHOSPHERE-ASTHENOSPHERE INTERACTION: A COMPARATIVE STUDY ON CENOZOIC AND MESOZOIC BASALTS AROUND BOHAI AREA | Yigang Xu Weiming Fan and Ge Lin( Guangzhou Institute of Geochemistry , Chinese Academy of Sciences , Guangzhou , P. R, China)(Department of Gedegy, Royal Holoway Univoersity of London, Egham, Surrey, TW20OEX , UK)(Changsha Institute of Geotectonics,Chin | 1995 | Geotectonica et Metallogenia1995，19，4： | 16 |
| 11 | 属特异性T-RFLP技术用于乳酸杆菌的群落分析显示文摘【目的】设计乳酸杆菌属特异性T-RFLP技术(末端限制性片段长度多态性分析)对14株乳酸杆菌进行分型。【方法】采用源于16S-23S rRNA基因间隔区序列的乳酸杆菌属特异性引物LAB-rev,乳酸杆菌的属特异性引物,6-FAM荧光标记后结合16S上游通用引物7f用于乳酸杆菌的PCR扩增。【结果】选取HaeⅢ和HhaⅠ进行限制性酶切,最后对酶切后的产物末端测序得到T-RFLP峰谱图,该图谱能够快速准确地对不同种的乳酸杆菌进行定性、定量的分析。【结论】实验成功搭建T-RFLP技术用于微生态环境中乳酸杆菌检测的平台,对于在功能性食品、乳酸饮料和药物对肠道微生态的影响及菌种鉴定等领域有重大意义。 | 张思璐 刘云霄 张浩琪 CHIN James 吴希阳 | 2012 | 微生物学通报2012，39，8： | 15 |
| 12 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 13 | Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China显示文摘In order to evaluate the performance of a molecular Hain line probe assay(Hain LPA)for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China。 | LI Qiang DONG Hai Yan PANG Yu XIA Hui OU Xi Chao ZHANG Zhi Ying LI Jun Chen ZHANG Jian Kang HUAN Shi Tong CHIN Daniel P KAM Kai Man ZHAO Yan Lin | 2015 | Biomedical and Environmental Sciences2015，28，6： | 13 |
| 14 | miRNA studies in in vitro and in vivo activated hepatic stellate cells显示文摘AIM: To understand which and how different miRNAs are implicated in the process of hepatic stellate cell (HSC) activation. METHODS: We used microarrays to examine the differential expression of miRNAs during in vitro activation of primary HSCs (pHSCs). The transcriptome changes upon stable transfection of rno-miR-146a into an HSC cell line were studied using cDNA microarrays. Selected differentially regulated miRNAs were investigated by quantitative real-time polymerase chain reaction during in vivo HSC activation. The effect of miRNA mimics and inhibitor on the in vitro activation of pHSCs was also evaluated.RESULTS: We found that 16 miRNAs were upregulated and 26 were downregulated significantly in 10-d in vitro activated pHSCs in comparison to quiescent pHSCs. Overexpression of rno-miR-146a was characterized by marked upregulation of tissue inhibitor of metalloproteinase-3, which is implicated in the regulation of tumor necrosis factor-α activity. Differences in the regulation of selected miRNAs were observed comparing in vitro and in vivo HSC activation. Treatment with miR-26a and 29a mimics, and miR-214 inhibitor during in vitro activation of pHSCs induced significant downregulation of collagen type Ⅰ transcription. CONCLUSION: Our results emphasize the different regulation of miRNAs in in vitro and in vivo activated pHSCs. We also showed that miR-26a, 29a and 214 are involved in the regulation of collagen type I mRNA. | Gunter Maubach Michelle Chin Chia Lim Henry Yang | 2011 | World Journal of Gastroenterology2011，17，22： | 12 |
| 15 | A light-weight high-entropy alloy Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35)显示文摘A light-weight high-entropy alloy(LWHEA) Al_(20)Be_(20)Fe_(10)Si_(15)Ti_(35) has been developed to have unique mechanical properties and oxidation resistance. One major and two minor phases are observed in the as-cast microstructure. The density of the alloy is3.91 g cm^(-3), and its hardness is HV 911, which is higher than quartz. The hardness and hardness to density ratio are the highest of all light-weight alloys reported before. In addition, it has excellent oxidation resistance at 700℃ and 900℃, which far exceeds that of Ti-6 A1-4 V. Thus, the combination of properties is promising for high-temperature applications, which require light weight,wear-resistant and oxidation-resistant components. | tseng kokai yang yachu juan chienchang chin tsungshune tsai chewei yeh jienwei | 2018 | Science China(Technological Sciences)2018，61，2： | 12 |
| 16 | Study on Lymphokine-Activated Killer Cells Induced from Cord Blood显示文摘 | Wang Yi-feng, et al. Affiliated Hospital, Shandong Med Uni, Jinan 250012. Chin J Obst Gynecol 1994 | 1994 | Chinese Medical Journal1994，，8： | 12 |
| 17 | A STUDY ON LANDSCAPE MOSAIC STRUCTUREIN URBANRURAL AREA IN NORTHWESTOF CHINA WITH RS AND GIS- A Case Study of Xigu District in Lanzhou City显示文摘ABSTRACT: At the study area of Xigu District in Lanzhou City, using RS & GIS as tools we apply Diversity, Dominance, Fragmentation , Isolation and so on to study the quantitative, fractal and spatial characters of landscapes’ structures in the four sub-regions divided by the morphological features. Using the Fractal Theory to establish the fractal structure models, we analyze the complexity and stability of various landscapes’ distribution with fractal dimension value. The spatial distribution characteristics of landscape mosaic structure are also expounded. At the end of the paper we discuss the relevant problems on the main factors which control and effect on the spatial pattern of landscapes as well as on landscape optimization and management. | XU Jian-hua1, LU Yan1, AI Nan-shan2, YUE Wen-ze3(1. Department of Geography, East China Normal University, Shanghai 200062, P. R. China 2. Environmental Science and Engineering School, Sichuan University, Chengdu 610064, P. R. Chin | 2001 | Chinese Geographical Science2001，11，4： | 12 |
| 18 | Role of electrodes in ambient electrolytic decomposition of hydroxylammonium nitrate (HAN) solutions显示文摘Decomposition of hydroxylammonium nitrate (HAN) solution with electrolytic decomposition method has attracted much attention in recent years due to its efficiencies and practicability.However,the phenomenon has not been well-studied till now. By utilizing mathematical model currently available,the effect of water content and power used for decomposition was studied. Experiment data shows that sacrificial material such as copper or aluminum outperforms inert electrodes in the decomposition of HAN solution. In the case of using copper wire to electrolyse HAN solutions, approximately 10 seconds is required to reach 100℃ regardless of concentration of HAN. In tem of power consumption,100W-300W was found to be the range in which decomposition could be triggered effectively using copper wire as electrodes. | Kai SengKoh Jitkai Chin Tengku F.Wahida Ku Chik | 2013 | Propulsion and Power Research2013，2，3： | 12 |
| 19 | Geometry Design and Tooth Contact Analysis of Crossed Beveloid Gears for Marine Transmissions显示文摘Beveloid gears,also known as conical gears,gain more and more importance in industry practice due to their abilities for power transmission between parallel,intersected and crossed axis.However,this type of gearing with crossed axes has no common plane of action which results in a point contact and low tooth durability.Therefore,a geometry design approach assuming line contact is developed to analyze the tooth engagement process of crossed beveloid gears with small shaft angle for marine transmission applications.The loaded gear tooth contact behavior is simulated by applying a quasi-static analysis to study the effects of gearing parameters on mesh characteristics.Using the proposed method,a series of sensitivity analyses to examine the effects of critical gearing parameters such as shaft angle,cone angle,helix angle and profile-shift coefficient on the theoretical gear mesh is performed.The parametric analysis of pitch cone design shows that the dominant design parameters represented by the angle between the first principle directions(FPD) and normal angular factor are more sensitive to the shaft and cone angles than they are to the helix angle.The theoretical contact path is highly sensitive to the profile-shift coefficient,which is determined from the theoretical tooth contact analysis.The FPD angle is found to change the distribution of contact pattern,contact pressure and root stress as well as the translational transmission error and the variation of the mesh stiffness significantly.The contact pattern is clearly different between the drive and coast sides due to different designed FPD angles.Finally,a practical experimental setup for marine transmission is performed and tooth bearing test is conducted to demonstrate the proposed design procedure.The experimental result compared well with the simulation.Results of this study yield a better understanding of the geometry design and loaded gear mesh characteristics for crossed beveloid gears used in marine transmission. | ZHU Caichao SONG Chaosheng LIM Teik Chin VIJAYAKAR Sandeep | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 11 |
| 20 | Microwave assisted digestion followed by ICP-MS for determination of trace metals in atmospheric and lake ecosystem显示文摘The study of trace metals in the atmosphere and lake water is important due to their critical effects on humans,aquatic animals and the geochemical balance of ecosystems. The objective of this study was to investigate the concentration of trace metals in atmospheric and lake water samples during the rainy season(before and after precipitation)between November and December 2015. Typical methods of sample preparation for trace metal determination such as cloud point extraction,solid phase extraction and dispersive liquid–liquid micro-extraction are time-consuming and difficult to perform; therefore,there is a crucial need for development of more effective sample preparation procedure. A convection microwave assisted digestion procedure for extraction of trace metals was developed for use prior to inductively couple plasma-mass spectrometric determination. The result showed that metals like zinc(133.50–419.30 μg/m^3)and aluminum(53.58–378.93 μg/m^3)had higher concentrations in atmospheric samples as compared to lake samples before precipitation.On the other hand,the concentrations of zinc,aluminum,chromium and arsenic were significantly higher in lake samples after precipitation and lower in atmospheric samples. The relationship between physicochemical parameters(pH and turbidity)and heavy metal concentrations was investigated as well. Furthermore,enrichment factor analysis indicated that anthropogenic sources such as soil dust,biomass burning and fuel combustion influenced the metal concentrations in the atmosphere. | Manan Ahmed Ying Hui Chin Xinxin Guo Xing-Min Zhao | 2017 | Journal of Environmental Sciences2017，29，5： | 11 |
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