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| 1 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 2 | The occlusal plane in the facial context:inter-operator repeatability of a new three-dimensional method显示文摘The repeatability of a non-invasive digital protocol proposed to evaluate the three-dimensional(3D) position of the occlusal plane in the face is assessed.Dental virtual models and soft tissue facial morphology of 20 adult subjects were digitally integrated using a 3D stereophotogrammetric imaging system.The digital 3D coordinates of facial and dental landmarks were obtained by two different operators.Camper's(facial) and occlusal(dental) planes were individuated,and their 3D relationships were measured.The repeatability of the protocol was investigated and showed no significant differences in repeated digitizations.The angle between occlusal and Camper's planes was smaller than 26 in the frontal and horizontal projections.In the sagittal projection,the angle was observed to be,on average,4.9 6.The determined occlusal plane pitch,roll and yaw values show good agreement with previously published data obtained by different protocols.The current non-invasive method was repeatable,without inter-operator differences and can facilitate assessment of healthy subjects. | Riccardo Rosati Alberto Rossetti Marcio De Menezes Virgilio F Ferrario Chiarella Sforza | 2012 | International Journal of Oral Science2012，4，1： | 2 |
| 3 | Heterogeneous Be-liefs,Risk and Learning in A Simple Asset Pricing Model with A Market Maker显示文摘 | | 2003 | Macroeconomic Dy-namlcs2003，7，： | 1 |
| 4 | Heterogeneous Beliefs, Risk and Learning in a Simple Asset Pricing Model 显示文摘 | Chiarella C He X | 2002 | Computational E-conomics2002，，19： | 1 |
| 5 | Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium显示文摘 | Chiarella AB Jolly DT Huston CM | 2003 | Br J Anaesth2003，90，3： | 1 |
| 6 | A dynamic analysis of moving average rules显示文摘 | Chiarella C | 2006 | Journal of Economic Dynamics & Control2006，30，： | 1 |
| 7 | Towards gene therapy for deafness显示文摘 | Di Domenico M Ricciardi C Martone T Mazzarella N. Cassandro C. Chiarella G. D'Angelo L. Cassandro E | | 0，，： | 1 |
| 8 | Asset price and wealth dynamics in a financialmarket with heterogeneous agents显示文摘 | Chiarella C | 2006 | Journal of Economic Dynamics & Control2006，30，： | 1 |
| 9 | Synthesis and field emission properties of vertically aligned carbon nanotube arrays on copper显示文摘 | NEUPANE S LASTRES M CHIARELLA M | 2012 | Carbon2012，50，7： | 1 |
| 10 | Advanced nursing practice显示文摘 | Chiarella M | 2006 | Journal of Advanced Nursing2006，8，55： | 1 |
| 11 | Changes in clinical andinstrumental vestibular parameters following acute exposition toauditory stress显示文摘 | Cassandro E Chiarella G Catalano M | 2003 | Acta Otorhinolaryngol Ital2003，23，4： | 1 |
| 12 | Percutaneous ethanol injection may be a definitive treatment for symptomatic thyroid cystic nodules not treatable by surgery:five-year follow-up study显示文摘 | Zingrillo M Torlontano M Chiarella R | 1999 | Thyroid1999，9，8： | 1 |
| 13 | Asset price and wealth dynamics under heterogeneous expectations 显示文摘 | Chiarella C He X | 2001 | Quantitative Finance2001，1，5： | 1 |
| 14 | A Complete Markovian Stochastic Volatility Model in the HJM Framework 显示文摘 | Carl Chiarella Oh Kangkwon | 2000 | Asia-Pacific Financial Market2000，7，： | 1 |
| 15 | The dynamics of speculative behaviour显示文摘 | Chiarella C | 1992 | Annals of Operations Research1992，37，1： | 1 |
| 16 | Transformation of Heath-Jarrow-Morton Models to Markovian Systems 显示文摘 | Bhar R Chiarella C | 1997 | European Journal of Fi- nance1997，3，： | 1 |
| 17 | The impact of heterogeneous trading rules on the limit order book and order flows显示文摘 | Carl Chiarella Giulia Iori Josep Perelló | 2008 | Journal of Economic Dynamics and Control2008，，3： | 1 |
| 18 | Identification of a neck lump as a lymph node metastasis from an occult contralateral papillary microcarcinoma of the thyroid:key role of thyroglobulin assay in the fine-needle aspirate显示文摘 | Bruno R Giannasio P Chiarella R | 2009 | Thyroid2009，19，5： | 1 |
| 19 | Pitfalls in CT-guided transthoracic needle biopsy of pulmonary nodules 显示文摘 | Davis SD Chiarella DA | 1996 | Radiographics1996，16，： | 1 |
| 20 | Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium显示文摘 | Chiarella A B Jolly D T Huston C M Clanachan A S | 2003 | Br J Anaesth2003，90，： | 1 |
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