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| 1 | Examining patterns of traditional chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study显示文摘Background Traditional Chinese medicine(TCM)is becoming a popular complementary approach in pediatric oncology.However,few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.Objective We explored the patterns of TCM use and its efficacy in children with cancer,using a systematic review,meta-analysis and data mining study.Search strategy We conducted a search of five English(Allied and Complementary Medicine Database,Embase,PubMed,Cochrane Central Register of Controlled Trials,and ClinicalTrials.gov)and four Chinese databases(Wanfang Data,China National Knowledge Infrastructure,Chinese Biomedical Literature Database,and VIP Chinese Science and Technology Periodicals Database)for clinical studies published before October 2021,using keywords related to“pediatric,”“cancer,”and“TCM.”Inclusion criteria We included studies which were randomized controlled trials(RCTs)or observational clinical studies,focused on patients aged<19 years old who had been diagnosed with cancer,and included at least one group of subjects receiving TCM treatment.Data extraction and analysis The methodological quality of RCTs and observational studies was assessed using the six-item Jadad scale and the Effective Public Healthcare Panacea Project Quality Assessment Tool,respectively.Meta-analysis was used to evaluate the efficacy of combining TCM with chemotherapy.Study outcomes included the treatment response rate and occurrence of cancer-related symptoms.Association rule mining(ARM)was used to investigate the associations among medicinal herbs and patient symptoms.Results The fifty-four studies included in this analysis were comprised of RCTs(63.0%)and observational studies(37.0%).Most RCTs focused on hematological malignancies(41.2%).The study outcomes included chemotherapy-induced toxicities(76.5%),infection rate(35.3%),and response,survival or relapse rate(23.5%).The methodological quality of most of the RCTs(82.4%)and observational studies(80.0%)was rated as“moderate.”In studies of leukemia patients,adding TCM to conventional treatment significantly improved the clinical response rate(odds ratio[OR]=2.55;95%confidence interval[CI]=1.49-4.36),lowered infection rate(OR=0.23;95%CI=0.13-0.40),and reduced nausea and vomiting(OR=0.13;95%CI=0.08-0.23).ARM showed that Radix Astragali,the most commonly used medicinal herb(58.0%),was associated with treating myelosuppression,gastrointestinal complications,and infection.Conclusion There is growing evidence that TCM is an effective adjuvant therapy for children with cancer.We proposed a checklist to improve the quality of TCM trials in pediatric oncology.Future work will examine the use of ARM techniques on real-world data to evaluate the efficacy of medicinal herbs and drug-herb interactions in children receiving TCM as a part of integrated cancer therapy. | Chun Sing Lam Li Wen Peng Lok Sum Yang Ho Wing Janessa Chou Chi-Kong Li Zhong Zuo Ho-Kee Koon Yin Ting Cheung | 2022 | Journal of Integrative Medicine2022，20，5： | 2 |
| 2 | Students' and in- structors' use of massive open online courses (MOOCs) : Motivations and challenges 显示文摘 | Khe Foon Hew Wing Sum Cheung | 2014 | Educational Research Review2014，，05： | 1 |
| 3 | Oscillation criteria for first and second order difference equations with mixed nonlinearities显示文摘 | AGARWAL Ravi P BOTHNER Martin CHEUNG Wing sum | 2007 | Mathematical and Computer Modelling2007，45，： | 1 |
| 4 | Students' and instructors' use of massive open online courses (MOOCs): Motivations and challenges显示文摘 | Khe Foon Hewa Wing Sum Cheung | 2014 | Educational Research Review2014，，12： | 1 |
| 5 | Student contribution in asynchronous online discussion: a review of the research and empirical exploration显示文摘 | Khe Foon Hew Wing Sum Cheung Connie Siew Ling Ng | 2008 | Instructional Science2008，11，： | 1 |
| 6 | Students' and Instruc- tors' Use of Massive Open Online Courses (MOOCs) : Mo- tivations and Challenges 显示文摘 | Khe Foon Hewa Wing Sum Cheung | 2014 | Educational Research Re- view2014，，12： | 1 |
| 7 | Positive Periodic Solution of Second-order Neutral Function Differential Equations显示文摘 | Cheung Wing Sum Ren Jingli Han Weiwei | 2009 | Nonlinear Analysis2009，71，： | 1 |
| 8 | On the existence of periodic solutions for p-Laplacian generalized Li e nard equation显示文摘 | Cheung Wing sum Ren Jingli | 2005 | Journal of Mathematical Analysis and Applications2005，60，1： | 1 |
| 9 | Students’ and instructors’ use of massive open online courses (MOOCs): Motivations and challenges显示文摘 | Khe Foon Hew Wing Sum Cheung | 2014 | Educational Research Review2014，，： | 1 |
| 10 | Critical Thinking in Asynchronous Online Discussion: An Investigation of Student Facilitation Techniques显示文摘 | LIM Sze Chung Raymond CHEUNG Wing Sum HEW Khe Foon | 2011 | New Horizons in Education2011，5，： | 1 |
| 11 | Determination of convex bodies from Γ-section functions显示文摘In this paper,we prove that any polygon P in R^2 containing a fixed smooth,strictly convex and origin-symmetric bodyΓwhose boundary is real analytic in its interior,can be determined by itsΓ-section functions among the polygons. | 熊革 马艳伟 CHEUNG Wing—sum | 2008 | Journal of Shanghai University(English Edition)2008，12，3： | 0 |
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