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| 1 | Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis显示文摘 | Chern M S Fitzgerald H A Yadav R C | 2001 | Plant J2001，27，2： | 2 |
| 2 | Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways显示文摘Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways. | Muhammad Asif Armaghan Shafaei Aman Shah Abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin Malik Shah Abdul Majid | 2017 | Chinese Journal of Natural Medicines2017，15，7： | 2 |
| 3 | The upper ocean response to a moving typhoon显示文摘 | Tsai Y L Chern C S Wang J | 2008 | Journal of Oceanography2008，64，11： | 1 |
| 4 | The growth of transparent conducting ZnO films by pulsed laser ablation显示文摘 | Henley S J Ashfold M N R Cherns D | 2004 | Surface and Coating Technology2004，，177178： | 1 |
| 5 | Protective effect of methyl gallate from Toona sinensis (Meliaceae) against hydrogen peroxide-induced oxidative stress and DNA damage in MDCK cells 显示文摘 | Hsieh T J Liu T Z Chia Y C Chern C L Lu F J Chuang M C Mau S Y Chen S H Syu Y H Chen C H | 2004 | Food and Chemical Toxicology2004，42，5： | 1 |
| 6 | Emulsion polymerization of styrene stabilized by mixed anionic and nonionic -surfactants 显示文摘 | Chern C S Lin S Y Chen L J | 1997 | Polymer1997，38，5： | 1 |
| 7 | Lie groups and KdV equations显示文摘 | S S Chern C K Peng | 1979 | Manuscr Math1979，28，： | 1 |
| 8 | Damping Properties of Interpenetrating Polymer Networks of Polyurethane-Modified E- poxy and Polyurethanes 显示文摘 | CHERN Y C TSENG S M HSIEH K H | 1999 | Journal of Applied Polymer Sci- ence1999，74，2： | 1 |
| 9 | Numerical study of the upper-layer circulation in the South China Sea显示文摘 | Chern C S Wang J | | 0，，01： | 1 |
| 10 | An Inventory Model for Increasing Demand under Two Levels of Trade Credit Linked to Order Quantity显示文摘 | Teng J T Yang G L Chern M S | 2013 | Applied Mathematical Modelling2013，，37： | 1 |
| 11 | Harmonic maps of the two-sphere in a complex Grassmann manifold显示文摘 | CHERN S S WOLFSON J G | 1987 | Ann Math1987，125，2： | 1 |
| 12 | Partial backlogging inventory lot-size models for deteriorating items with fluctuating demand under inflation 显示文摘 | Chern M S Yang H L Teng J T Papachristos S | 2008 | European Journal of Operational Research2008，191，1： | 1 |
| 13 | The intrusion of the Kuroshio Across the continental shelf northeast of Taiwan显示文摘 | HSUEH Y WANG J CHERN C S | 1992 | Journal of Geophysics Research1992，97，14： | 1 |
| 14 | The anomalous amplification of M2 tide in the Taiwan Strait显示文摘 | Jan S Chern C S Wang J | 2004 | Geophysical Research Letters2004，31，： | 1 |
| 15 | Optimal manu- facturer's replenishment policies for deteriorating items in a supply chain with up-stream and down-stream trade credits 显示文摘 | Chang Chuntao Teng J T Chern M S | 2010 | International Journal of Production Econom- ics2010，127，1： | 1 |
| 16 | Stackelberg Solution in a Vendor-buyer Supply Chain Model with Permissible Delay in Payments显示文摘 | Chern M S Pan Q Teng J T | 2013 | International Journal of Production Economics2013，，144： | 1 |
| 17 | Cadmiuminduced lipid peroxidation in rat testes and protection by selenium 显示文摘 | YIIN S J CHERN C L SHEU J Y | 1999 | Bio Metals1999，12，： | 1 |
| 18 | The most vital edges in the minimum spanning tree problem显示文摘 | Lin K C Chern M S | 1993 | Information Proceeding Letters1993，，45： | 1 |
| 19 | Optimized back-analysis for tunneling-induced ground movement using equivalent ground loss model显示文摘 | CHI S Y CHERN J C LIN C C | 2001 | Tunnelling and Underground Space Technology2001，16，3： | 1 |
| 20 | Over expression of (At)NPR1 in rice leads to a BTH- and environment-induced lesion-mimic/cell death phenotype显示文摘 | Fitzgerald H A Chern M S Navarre R | 2004 | Mol Plant Microbe Interact2004，17，2： | 1 |
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