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| 1 | Transjugular intrahepatic portosystemic shunt for the management of acute variceal hemorrhage显示文摘Acute variceal hemorrhage,a life-threatening condition that requires a multidisciplinary approach for effective therapy,is defined as visible bleeding from an esophageal or gastric varix at the time of endoscopy,the presence of large esophageal varices with recent stigmata of bleeding,or fresh blood visible in the stomach with no other source of bleeding identified.Transfusion of blood products,pharmacological treatments and early endoscopic therapy are often effective;however,if primary hemostasis cannot be obtained or if uncontrollable early rebleeding occurs,transjugular intrahepatic portosystemic shunt(TIPS)is recommended as rescue treatment.The TIPS represents a major advance in the treatment of complications of portal hypertension.Acute variceal hemorrhage that is poorly controlled with endoscopic therapy is generally well controlled with TIPS,which has a 90%to 100%success rate.However,TIPS is associated with a mortality of 30%to 50%in such a setting.Emergency TIPS should be considered early in patients with refractory variceal bleeding once medical treatment and endoscopic sclerotherapy failure,before the clinical condition worsens.Furthermore,admission to specialized centers is mandatory in such a setting and regional protocols are essential to be organized effectively.This review article discusses initial management and then focuses on the specific role of TIPS as a primary therapy to control acute variceal hemorrhage,particularly as a rescue therapy following failure of endoscopic approaches. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Sylvain Favelier Pierre Pottecher Samia Hamza Anne Minello Patrick Hillon Pierre Thouant Pierre-Henri Lefevre Denis Krausé Jean-Pierre Cercueil | 2013 | World Journal of Gastroenterology2013，19，37： | 25 |
| 2 | Current limita- tions and future opportunities for epigenetic therapies 显示文摘 | Cherblanc F Chapman- Rothe N Brown R | 2012 | Future Med Chem2012，4，4： | 1 |
| 3 | lnflu-ence of liquid bridges on the mechanical behavior of polydisperse granular materials 显示文摘 | Soulie F Cherblanc F Youssoufi M S E | 2006 | International Journal for Numerical and Analytical Methods in Geomechanics2006，30，： | 1 |
| 4 | Mechanical behaviour and failure of cohesive granular materials显示文摘 | DELENNE J Y YOUSSOUFI M S E CHERBLANC F | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 5 | C-arm dual-phase conebeamCT: a revolutionary real-time imaging modality to assess drugelutingbeads TACE success in liver cancer patients显示文摘 | Loffroy R Favelier S Cherblanc V | 2013 | QuantImaging Med Surg2013，3，4： | 1 |
| 6 | Mechanical behaviour and failure of cohesive granu- lar materials 显示文摘 | Delenne J Y Youssoufi M S E Cherblanc F Benet J C | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 7 | Chiroptical studies on brevianamide B : vibrational and electronic circular dichroism confronted 显示文摘 | Bultinck P Cherblanc FL Fuchter MJ | 2015 | J Org Chem2015，80，7： | 1 |
| 8 | Mechanical behaviour and failure of cohesive granular materials 显示文摘 | Delenne J Y Youssoufi M S E Cherblanc F | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 9 | Mechanical behaviour and failure of cohesive granular materials显示文摘 | DELENNE J Y YOUSSOUFI M S E CHERBLANC F | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 10 | Diagnosis of hepatocellular carcinoma显示文摘 | Cherblanc V Guiu B | | 0，，： | 1 |
| 11 | Mechanical behavior and failure of cohesive granular materials显示文摘 | DELENNE J Y YOUSSOUFI M S E CHERBLANC F | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 12 | Mechanical behaviour and failure of cohesive granular materials显示文摘 | DELENNE J Y MOULAY S E L Y CHERBLANC F | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，15： | 1 |
| 13 | Mechanical behavior and failure of cohesive granular materials显示文摘 | Delenne J Y Youssoufi M S E Cherblance | 2004 | International Journal for Numerical and Analysis Methods in Geomechanics2004，28，15： | 1 |
| 14 | Transcatheter embolization as the new reference standard for endoscopically unmanageable upper gastrointestinal bleeding显示文摘Acute nonvariceal upper gastrointestinal bleeding(UGIB) is a major medical emergency problem associated with significant morbidity and mortality.Endoscopy is considered the first method of choice to detect and treat UGIB.Endoscopic therapy usually achieves primary hemostasis,but 10%-30% of these patients have repeat bleeding.In patients in whom hemostasis is not achieved with endoscopic techniques,treatment with transcatheter angiographic embolization(TAE) or surgery is needed.Surgical intervention is usually an expeditious and gratifying endeavor,but it can be associated with high operative mortality rates.A large number of studies support the use of TAE as salvage therapy as an alternative to surgery.However,few studies have compared the results of TAE with that of emergency surgery in terms of efficiency,the frequency of repeat bleeding,and complications.Recently,Ang et al retrospectively compared the outcome of TAE and surgery as salvage therapy of UGIB after failed endoscopic treatment.There were no significant differences in 30 d mortality,complication rates and length of stay although higher rebleeding rates were observed after TAE compared with surgery.In this commentary,we discuss the advantages and drawbacks of these two therapeutic strategies for UGIB.We also attempt to define the exact role of TAE for acute nonvariceal UGIB. | Romaric Loffroy Louis Estivalet Violaine Cherblanc Damien Sottier Boris Guiu Jean-Pierre Cercueil Denis Krausé | 2012 | World Journal of Gastrointestinal Surgery2012，4，10： | 0 |
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