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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | 显示文摘 | Ngagrarajan N Cheong M Zhitomirsky N | 2007 | Materials Chemistry and Physics2007，103，： | 1 |
| 3 | An assessment of a new diagnostic indi- rect enzyme immunoassay for the detection of anti-Mycoplasma Pneumoniae IgM显示文摘 | Cimolai N Cheong AC | 1996 | Am J Clin Pathol1996，105，2： | 1 |
| 4 | An assessment of a new diagnostic indirect enzyme immunoassay for the detection of anti - Myeoplasma pneumoniae IgM 显示文摘 | Cimolai N cheong ACH | 1996 | Am J Clin Pathol1996，105，： | 1 |
| 5 | Characteriza- tion of two fungal - elicitor induced rice cDNAs encoding functional homologues of the rab - specific GDP - dissoci- ation inhibitor显示文摘 | Kim W Y Kim C Y Cheong N E | 1999 | Planta1999，210，1： | 1 |
| 6 | An assessment of a new diagnosticindirect enzyme immunoassay foe the detection of anti _mycoplasma peneumoniae IgM 显示文摘 | Cimolai N Cheong AC | 1996 | Am J Clin Panthod1996，105，2： | 1 |
| 7 | Estimating the annual rate of de novo multiple aneurysms: three statistical approaches显示文摘 | Cheong JJ Ghinea N van Gelder JM | 2004 | Neurosurg Focus2004，17，5： | 1 |
| 8 | The Blomia tropicalis allergens显示文摘 | Chua KY Cheong N Kuo IC | 2007 | Protein Pept Lett2007，14，4： | 1 |
| 9 | Extractive desulfurization using Fe-cotaining ionic liquids 显示文摘 | KO N H LEE J S HUH E S LEE H JUNG K D K/M H S CHEONG M | 2008 | Energy Fuels2008，22，3： | 1 |
| 10 | An assessment of a new diagnostic indirect enzyme immunoassay foe the detection of anti-mycoplasma peneumoniae IgM显示文摘 | Cimolai N Cheong ACH | 1996 | Am J Clin Panthod1996，105，： | 1 |
| 11 | An assessment of a new diagnostic indirect enzyme immunoassay for the detection of anti-Mycoplama pneumoniae IgM显示文摘 | Cimolai N Cheong A | 1996 | Am J Clinical Pathol1996，105，： | 1 |
| 12 | Ef- fect of stillbirths on dam survival and reproduction perfor- mance in holstein dairy cows 显示文摘 | BICALHO R C GALVAO K N CHEONG S H | 2007 | Journal of Dairy Science2007，90，6： | 1 |
| 13 | Molecular clong and characterization of za class III chitinase in pumpkin leaves, which strongly binds to regenerate chitin affinity gel 显示文摘 | Kim M G Lee K O Cheong N E | 1999 | Plant Science1999，147，1： | 1 |
| 14 | Spin-polarized intergrain tunneling in La2/3Sr1/3MnO3显示文摘 | Hwang H Y Cheong S W Ong N P | 1996 | Phys Rev Lett1996，77，： | 1 |
| 15 | Multiferroics: Past, present,and future 显示文摘 | Spaldin N A Cheong S W Ramesh R | 2010 | Physics Today2010，63，10： | 1 |
| 16 | An assessment of a new diagnostic indirect enzyme immunoassay for the detection of anti-mycoplasma pneumoniae IgM显示文摘 | CIMOLAI N CHEONG A C H | 1996 | Am J Clin Pathol1996，105，： | 1 |
| 17 | Spin-polarized intergrain tunneling in La2/3Sr1/3MnO3显示文摘 | HWANG H Y CHEONG S W ONG N P BATLOGG B | 1996 | Phys Rev Lett1996，77，： | 1 |
| 18 | The Blomia tropicalis allergens显示文摘 | CHUA K Y CHEONG N KUO I C | 2007 | Protein and Peptide Letters2007，14，4： | 1 |
| 19 | Spin-polarized intergrain tunneling in La2/3Sr1/3MnO3显示文摘 | HWANG H Y CHEONG S W ONG N P | 1996 | Phys Rev Lett1996，77，： | 1 |
| 20 | Spin-Polarized Intergrain Tunneling in La2/3 Sr1/3 MnO3显示文摘 | HWANG H Y CHEONG S-W ONG N P | 1996 | Phys Rev Lett1996，77，： | 1 |
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