4篇
您的检索式：作者名="Chenglan Wang"
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| 1 | Anomalous change of the Antarctic sea ice and global sea level change显示文摘AnomalouschangeoftheAntarcticseaiceandglobalsealevelchange￥XieSimei;ZouBing;WangYiandBaoChenglan(1.NationalMarineEnvironmentF... | Xie Simei Zou Bing Wang Yi and Bao Chenglan (National Marine Environment Forecasting Center, State oceanic Administration, Beijing 100081, China) | 1996 | Acta Oceanologica Sinica1996，15，2： | 1 |
| 2 | An Olefinic 1,2-α-Boryl Migration Enables 1,2-Bis(boronic esters)via Radical-Polar Crossover Reaction显示文摘A radical-induced 1,2-α-boryl migration through radical polar crossover reactions has been described.In this work,in situ formed vinyldiboron“ate”complexes from alkenyl Grignard reagent and diborylalkanes react with commercial radical precursors under light initiation.This three-component process enables diborylation of alkene.This protocol features high atom economy,a broad substrate scope as well as good functional group toleration with mild conditions. | Feng Zhang Shangteng Liao Lu Zhou Kai Yang Chenglan Wang Yixian Lou Cece Wang Qiuling Song | 2022 | Chinese Journal of Chemistry2022，40，5： | 0 |
| 3 | Photoinduced NaI-Promoted Radical Borylation of Alkyl Halides and Pseudohalides显示文摘Main observation and conclusion A method for photoinduced NaI-promoted radical borylation of aliphatic halides and pseudohalides with bis(catecholato)diboron(B_(2)cat_(2))as the boron source is introduced.The borylation reaction is operationally simple and shows high functional group tolerance and broad substrate scope.Preliminary mechanistic studies suggest that the reaction proceeds through S_(N)2-based radical-generation strategy. | Chenglan Wang Lu Zhou Kai Yang Feng Zhang Qiuling Song | 2021 | Chinese Journal of Chemistry2021，39，7： | 0 |
| 4 | E6-induced selective translation of WNT4 and JIP2 promotes the progression of cervical cancer via a noncanonical WNT signaling pathway显示文摘mRNA translation reprogramming occurs frequently in many pathologies,including cancer and viral infection.It remains largely unknown whether viral-induced alterations in mRNA translation contribute to carcinogenesis.Most cervical cancer is caused by high-risk human papillomavirus infection,resulting in the malignant transformation of normal epithelial cells mainly via viral E6 and E7 oncoproteins.Here,we utilized polysome profiling and deep RNA sequencing to systematically evaluate E6-regulated mRNA translation in HPV18-infected cervical cancer cells.We found that silencing E6 can cause over a two-fold change in the translation efficiency of~653 mRNAs,most likely in an eIF4E-and eIF2α-independent manner.In addition,we identified that E6 can selectively upregulate the translation of WNT4,JIP1,and JIP2,resulting in the activation of the noncanonical WNT/PCP/JNK pathway to promote cell proliferation in vitro and tumor growth in vivo.Ectopic expression of WNT4/JIP2 can effectively rescue the decreased cell proliferation caused by E6 silencing,strongly suggesting that the WNT4/JIP2 pathway mediates the role of E6 in promoting cell proliferation.Thus,our results revealed a novel oncogenic mechanism of E6 via regulating the translation of mRNAs. | Lin Zhao Longlong Wang Chenglan Zhang Ze Liu Yongjun Piao Jie Yan Rong Xiang Yuanqing Yao Yi Shi | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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