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| 1 | NK cell-based immunotherapy for malignant diseases显示文摘生来的杀手(NK ) 房间对癌症在主人免疫起关键作用。在反应,癌症开发机制逃离 NK 房间攻击或导致有缺点的 NK 房间。当前的 NK 基于房间的癌症免疫疗法试图用几条途径克服 NK 房间麻痹。一条途径使用扩展 allogeneic NK 房间,它没被象自体同源的 NK 房间一样的自我 histocompatibility 抗原禁止,为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的 allogeneic NK 房间线,它为质量控制和大规模生产是更实际的。第三条途径是新鲜 NK 房间或 NK 房间线的基因修正高度表示 cytokines, Fc 受体或妄想的肿瘤抗原受体。治疗学的 NK 细胞能从各种各样的来源被导出,包括细胞,干细胞或甚至导致的 pluripotent 干细胞( iPSCs ),和许多激发器能被用于的外设或绳索血在实验室或好生产实践( GMP )的大规模生产设备包括可溶的生长因素,使不能调动的分子或抗体,和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的 NK 房间治疗的一张表这里被考察。基于 NK 的免疫疗法的几条不同途径例如织物特定的 NK 房间,漂亮面向受体的 NK 房间和化学上对待的 NK 房间,被讨论。一些新技术或策略到由非侵略的成像的监视器 NK 房间治疗,预定 NK 房间治疗由的效率在 vivo 实验并且在临床的试用评估 NK 房间治疗途径也被介绍。 | Min Cheng Yongyan Chen Weihua Xiao Rui Sun Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，3： | 61 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | NK cell receptor imbalance and NK cell dysfunction in HBV nfection and hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 当前由于手术后的复发和转移是癌症死亡和普通差预后的恶意的第三个领先的原因。在长期的肝炎 B 之间有重要关联病毒(HBV ) 感染和 hepatocarcinogenesis。作为对病毒的感染和肿瘤的宿主防卫的第一根线,生来的杀手( NK )细胞表示很多有免疫力的识别受体( NK 受体( NKR ))在 hepatocytes ,肝正弦曲线 endothelial 细胞,星形的细胞和 Kupffer 细胞上认出 ligands ,它维持在有免疫力的反应和 NK 细胞的有免疫力的忍耐之间的平衡。不幸地,百分比和肝 NK 房间的绝对数字在 HCC 的发展和前进期间显著地减少。NK 房间受体和肝 NK 房间的机能障碍的反常表示贡献长期的 HBV 感染和 HCC 的前进并且显著地为肝癌症与差的预后被联系。在这评论,我们在 HCC 在反肿瘤免疫者回答集中于 NK 房间受体的角色,特别地 HBV 相关的 HCC。我们明确地讨论肿瘤房间怎么从 NK 房间躲避攻击并且 NKR 的新兴的理解怎么可以为 HCC 帮助新奇治疗的发展。小说单音 -- 并且指向 NK 房间 receptor-ligand 系统的治疗学的策略可以潜在地导致的联合在 HCC 的成功、有效的免疫疗法。 | Cheng Sun Haoyu Sun Cai Zhang Zhigang Tian | 2015 | Cellular & Molecular Immunology2015，12，3： | 55 |
| 4 | Empirical Changes in the Prevalence of Overweight and Obesity among Chinese Students from 1985 to 2010 and Corresponding Preventive Strategies显示文摘Objective To determine the extent of the obesity epidemic in school‐aged Chinese children in 2010 and track the increasing trend in different socioeconomic regions over the preceding 25 years. Strategies for preventing childhood obesity are suggested. Methods We used a dataset provided by the Chinese National Survey on Students' Constitution and Health from 1985‐2010. Subjects were 7‐18‐year‐old students randomly selected from urban and rural areas in 30 provinces. Eight subgroups were created according to region and socioeconomic status. Results Increased rates of the epidemic (overweight and obesity combined) were greatest in large coastal cities‐32.6% and 19.1% among males and females, respectively. These rates has neared that of developed countries. Similar increases were found in all other regions, including the once poverty‐stricken rural west. The epidemic in most of the rural areas began after 2000, but has spread swiftly over the last decade. In 2010, it was estimated that 9.9% of Chinese school‐aged children and adolescents were overweight and that an additional 5.1% were obese, representing an estimated 30.43 million individuals. Conclusion The prognosis for China's childhood‐obesity epidemic is dire. To prevent childhood obesity, we suggest several strategies, including reasonable dietary intake, increase physical activity, a change in sedentary lifestyles and corresponding behavioral modifications. | JI Cheng Ye CHEN Tian Jiao Working Group on Obesity in China (WGOC) | 2013 | Biomedical and Environmental Sciences2013，26，1： | 49 |
| 5 | Role of transvaginal contrast-enhanced ultrasound in the early diagnosis of endometrial carcinoma显示文摘背景子宫内膜的癌是最普通的妇产科的恶意在之中之一 women.Early 诊断和 myometrial 侵略的正确外科手术前的评估是必要的改进学习试图决定是否展示的 prognosis.This 和 transvaginal 的时间紧张曲线( TIC )提高对比的超声( CEUS )为子宫内膜的癌常规超声不同于那些,并且在 endometri 的早诊断探索 transvaginal CEUS 的临床的角色推进( 48/79 ) 60.8 与 hyperechoic 改进介绍了,( 22/79 ) 27.8 与 isoechoic 介绍了改进,并且( 9/79 ) 11.4 与 hypoechoic enhancement.The 一般水准到达时间介绍了,达到顶点的时间,上升时间,一半洗外面损害的时间比正常子宫内膜( P 0.05 )短 .The 一般水准山峰紧张,在紧张的相对上升,一半洗外面损害的紧张比正常子宫内膜( P0.05 ) .There 是 49 的高(必须是并且可能在场)由超声的子宫内膜的癌的盒子(美国24 个盒子与病理结果一致, 16 个盒子被低估, 9 个盒子是 overestimated.There 是 72 (必须是并且可能在场) 由 CEUS 的子宫内膜的癌的盒子; 53 个盒子与病理结果一致, 12 个盒子被低估, 7 个盒子是由 CEUS 的子宫内膜的癌的质的诊断是的 overestimated.The 比那更由由评估提高对比的模式并且分析 TIC 的美国( P 0.01 ) .Conclusions 精确、明确,我们发现 CEUS 能增加超声的精确性质的诊断子宫内膜的 carcinoma.CEUS 比常规超声更清楚地显示出损害,它是在评估 encroachm | Liu Ying Tian Jia-wei Xu Yi Cheng Wen | 2012 | Chinese Medical Journal2012，，3： | 36 |
| 6 | Supersonic flow imaging via nanoparticles显示文摘Due to influence of compressibility,shock wave,instabilities,and turbulence on supersonic flows, current flow visualization and imaging techniques encounter some problems in high spatiotemporal resolution and high signal-to-noise ratio(SNR)measurements.Therefore,nanoparticle based planar laser scattering method(NPLS)is developed here.The nanoparticles are used as tracer,and pulse planar laser is used as light source in NPLS;by recording images of particles in flow field with CCD, high spatiotemporal resolution supersonic flow imaging is realized.The flow-following ability of nanoparticles in supersonic flows is studied according to multiphase flow theory and calibrating experiment of oblique shock wave.The laser scattering characteristics of nanoparticles are analyzed with light scattering theory.The results of theoretical and experimental studies show that the dynamic behavior and light scattering characteristics of nanoparticles highly enhance the spatiotemporal resolution and SNR of NPLS,with which the flow field involving shock wave,expansion,Mach disk,boundary layer,sliding-line,and mixing layer can be imaged clearly at high spatiotemporal resolution. | ZHAO YuXin YI ShiHe TIAN LiFeng CHENG ZhongYu | 2009 | Science China(Technological Sciences)2009，52，12： | 31 |
| 7 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 8 | Effects of large dose of dexamethasone on inflammatory mediators and pancreatic cell apoptosis of rats with severe acute pancreatitis显示文摘AIM: To investigate the influence of high dose of dexamethasone on inflammatory mediators and apoptosis of rats with severe acute pancreatitis (SAP). METHODS: SAP rats were randomly assigned to the model group and treatment group while the normal rats were assigned to the sham operation group. The mortality,ascite volumes,ascites/body weight ratio and pancreas pathological changes of all rats were observed at 3,6 and 12 h after operation. Their contents of amylase and endotoxin in plasma and contents of tumor necrosis factor (TNF-α),phospholipase A2 (PLA2) and IL-6 in serum were also determined. The microarray sections of their pancreatic tissues were prepared,terminal transferase dUTP nick end labeling (TUNEL) staining was performed and apoptotic indexes were calculated. RESULTS: There was no marked difference between treatment group and model group in survival. The contents of amylase and endotoxin in plasma and contents of TNF-α,PLA2 and IL-6 in serum,ascite volumes,ascites/body weight ratio and pancreas pathological scores were all lower in treatment group than in model group to different extents at different time points P < 0.05,58.3 (26.4) ng/L vs 77.535 (42.157) ng/L in TNF-α content,8.00 (2.00) points vs 9.00 (2.00) points in pathological score of pancreas respectively; P < 0.01,0.042 (0.018) EU/mL vs 0.056 (0.0195) EU/mL in endotoxin content,7791 (1863) U/L vs 9195 (1298) U/L in plasma amylase content,1.53 (0.79) vs 2.38 (1.10) in ascites/body weight ratio,8.00 (1.00) points vs 11.00 (1.50) points in pathological score of pancreas; P < 0.001,3.36 (1.56) ng/L vs 5.65 (1.08) ng/L in IL-6 content,4.50 (2.00) vs 7.20 (2.00),4.20 (1.60) vs 6.40 (2.30),3.40 (2.70) vs 7.90 (1.70) in ascite volumes,respectively. The apoptotic indexes of pancreas head and pancreas tail were all higher in treatment group than in model group at 6 h P < 0.01,0.00 (2.00)% vs 0.00 (0.00)%,0.20 (1.80) vs 0.00 (0.00) in apoptosis indexes,respectively. CONCLUSION: The mechanism of dexamethasone treatment in acute pancreatitis is related to its inhibition of inflammatory mediator generation and induction of pancreatic acinar cell apoptosis. | Xi-Ping Zhang Li Chen Qi-Fang Hu Hua Tian Ru-Jun Xu Zhi-Wei Wang Ke-Yi Wang Qi-Hui Cheng Wei Yan Yun Li Qing-Yu Li Qing He Fei Wang | 2007 | World Journal of Gastroenterology2007，13，41： | 29 |
| 9 | Sample maturation calculated using Raman spectroscopic parameters for solid organics: Methodology and geological applications显示文摘The shape and shift of Raman peak of solid organics prove to be capable of revealing atomic and molecular level vibration information of aromatic ring structure and its relationship with sample maturation. Raman 'D' peaks and 'G' peaks of a series of continuously maturated coal samples were measured, and the inter-peak intervals (G-D) and peak height ratios (Dh/Gh) were derived and correlated with the vitrinite reflectance (vRo%) of standard coal samples. As a result, two formulae were established by using the two Raman indices for calculation of Raman reflectance (RmcRo%), which is equivalent to vitrinite reflectance. The formula for calculating Raman reflectance indicative of organic maturation using Raman shift inter-peak interval (G-D) is RmcRo%=0.0537d(G-D)-11.21, which is mainly applicable to matured to highly matured carbonized samples of solid organics; The formula for calculating Raman reflectance indicative of organic maturation using Raman peak height ratio (Dh/Gh) is RmcRo%=1.1659h (Dh/Gh)+2.7588, which is mainly applicable to carbonized samples of solid organics that are over matured or going to be turned into granulated graphite. Preliminary applications indicate that Raman reflectance 'RmcRo%' calculated based on results of Raman spectral analysis of solid organics can be used to characterize sample maturation at molecular level, so enjoying extensive prospects in geological applications. | LIU DeHan XIAO XianMing TIAN Hui MIN YuShun ZHOU Qin CHENG Peng SHEN JiaGui | 2013 | Chinese Science Bulletin2013，58，11： | 30 |
| 10 | The fractal measurement of experimental images of supersonic turbulent mixing layer显示文摘Flow visualization of supersonic mixing layer has been studied based on the high spatiotemporal resolution Nano-based Planar Laser Scattering(NPLS) method in SML-1 wind tunnel. The corresponding images distinctly reproduced the flow structure of laminar,transitional and turbulent region,with which the fractal measurement can be implemented. Two methods of measuring fractal dimension were introduced and compared. The fractal dimension of the transitional region and the fully developing turbulence region of supersonic mixing layer were measured based on the box-counting method. In the transitional region,the fractal dimension will increase with turbulent intensity. In the fully developing turbulent region,the fractal dimension will not vary apparently for different flow structures,which em-bodies the self-similarity of supersonic turbulence. | ZHAO YuXin YI ShiHe TIAN LiFeng HE Lin CHENG ZhongYu | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，8： | 24 |
| 11 | A multi-center study of hemodynamic characteristics exhibited by children with unexplained syncope显示文摘Background Syncope is common in children and adolescents,with 15% estimated to have had at least one syncopal episode by age 18.In recent years,an increasing number of children,especially girls at their school age,have developed unexplained syncope.The mechanism of an unexplained syncope exhibited by children is incompletely studied;the association between different hemodynamic patterns and clinical features is also not clear.The aim of the study was to investigate the hemodynamic patterns of children with unexplained syncope and to examine the clinical relevance.Methods Two hundred and eight children [87 boys,121 girls,aged 3-19 years,mean(11.66±2.72) years] were selectively recruited from May 2000 to April 2006 when they presented syncope as their main complaint at the Multi-center Network for Childhood Syncope in Beijing,Hunan Province,Hubei Province,and Shanghai of China.All of the patients underwent head-up tilt tests;data were analyzed using SPSS version 10.0 for Windows.Continuous variables were expressed as the mean±standard deviation.Dichotomous variables were compared through a χ2 test.A value of P<0.05(two sided) was regarded as statistically significant.Results The age distribution of children with syncope was approximately normal.Head-up tilt tests was positive in 155 children,and the incidence of positive response of the baseline head-up tilt test for diagnosing unexplained syncope was 50.48%.The sensitivity value and diagnostic value of sublingual nitroglycerin head-up tilt test were both 74.52%.The hemodynamic pattern was normal in 53 children.The 155 children,who were positive in head-up tilt tests,showed signs of postural orthostatic tachycardia syndrome(60,28.8%),the vasoinhibitory pattern(72,34.6%),the cardioinhibitory pattern(5,2.4%),and the mixed pattern(18,8.7%).The gender distribution between the two age groups(age < 12 years vs age ≥ 12 years) was not different(P>0.05).The distribution of hemodynamic patterns between the children of the two age groups(age < 12 years vs age ≥ 12 years),and the children with different complaints(dizziness vs syncope) was significantly different(P<0.05),while the distribution between the children of different sexes and different lasting time of syncope(≤ 5 minutes vs> 5 minutes) was not significantly different(P>0.05).Different hemodynamic patterns were differentiated by differing syncope inducements,presymptoms,and complicated symptoms during and after syncope.Conclusion The tested girls were more prone when compared with the boys to have unexplained syncope,and the peak age was around twelve years old.The incidence of positive response of head-up tilt tests was also relatively higher for the girls.The distribution of hemodynamic patterns for different ages was different.For children with unexplained syncope,we should use head-up tilttests to distinguish the hemodynamic patterns in order to adopt rational therapeutic measures. | CHEN Li YANG Yuan-yuan WANG Cheng WANG Hong-wei TIAN Hong ZHANG Qing-you CHEN Jian-jun WANG Yu-li KANG Yi-long TANG Chao-shu DU Jun-bao | 2006 | Chinese Medical Journal2006，，24： | 23 |
| 12 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 13 | Trends in particulate matter and its chemical compositions in China from 2013–2017显示文摘Accurate determination of the atmospheric particulate matter mass concentration and chemical composition is helpful in exploring the causes and sources of atmospheric enthalpy pollution and in evaluating the rationality of environmental air quality control strategies.Based on the sampling and chemical composition data of PM2.5 in different key regions of China in the CARE-China observation network,this research analyzes the environmental air quality data released by the China National Environmental Monitoring Centre during the studied period to determine the changes in the particulate matter mass concentration in key regions and the evolution of the corresponding chemical compositions during the implementation of the Action Plan for Prevention and Control of Air Pollution from 2013-2017.The results show the following.(1)The particulate matter mass concentration in China showed a significant downward trend;however,the PM2.5 annual mass concentration in 64%of cities exceeds the New Chinese Ambient Air Quality Standard(CAAQS)GradeⅡ(GB3095-2012).The region to the east of the Taihang Mountains,the Fenhe and Weihe River Plain and the Urumqi-Changji regions in Xinjiang,all have PM2.5 concentration loading that is still high,and heavy haze pollution occurred frequently in the autumn and winter.(2)During the heavy pollution in the autumn and winter,the concentrations of sulfate and organic components decreased significantly.The mean SO42-concentration in PM2.5 decreased by 76%,12%,81%and 38%in Beijing-Tianjin-Hebei(BTH),the Pearl River Delta(PRD),the Sichuan-Chongqing region(SC)and the Fenhe and Weihe River Plain,respectively.The mean organic matter(OM)concentration decreased by 70%,44%,48%and 31%,respectively,and the mean concentration of NH4+decreased by 68%,1.6%,38%and 25%,respectively.The mean elemental carbon(EC)concentration decreased by 84%and 20%in BTH and SC,respectively,and it increased by 61%and 11%in the PRD and Fenhe and Weihe River Plain,respectively.The mean concentration of mineral and unresolved chemical components(MI)dropped by 70%,24%and 13%in BTH,the PRD and the Fenhe and Weihe River Plain,respectively.The change in the PM2.5 chemical composition is consistent with the decrease of the PM2.5mass concentration.(3)In 2015,the mean OM concentration contributions to fine particles and coarse particles were 13-46%and 46-57%,respectively,and the mean MI concentration contributions to fine particles and coarse and particles were 31-60%and 39-73%,respectively;these values are lower than the 2013 values from the key regions,which is the most important factor behind the decrease of the particulate matter mass concentration.From 2013 to 2015,among the chemical components of different particle size fractions,the peak value of the coarse particle size fraction decreased significantly,and the fine particle size fractions of SO42-,NO3-,and NH4+decreased with the decrease of the particulate matter mass concentration in different particle size fractions.The fine-particle size peaks of SO42-,NO3-and NH4+shifted from 0.65-1.1μm to the finer size range of0.43-0.65μm during the same time frame. | Yuesi WANG Wenjie LI Wenkang GAO Zirui LIU Shili TIAN Rongrong SHEN Dongsheng JI Shuai WANG Lili WANG Guiqian TANG Tao SONG Mengtian CHENG Gehui WANG Zhengyu GONG Jiming HAO Yuanhang ZHANG | 2019 | Science China Earth Sciences2019，62，12： | 23 |
| 14 | Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea显示文摘新地震数据的学习在架并且在 Qiongdongnan 盆(QDNB ) 的深渊的设定上以内部建筑学和分发允许沉积严肃流动的鉴定。六种严肃流动类型被认出:(1 ) 有基础、一致的 truncational 的 turbidite 隧道压垂沿着架边和斜坡的关系,包括旁边地转移、使河床升高得垂直地的隧道建筑群;(2 ) 有塑造汤勺的形态学的滑坡在架裂缝上滑动步并且从变丑产生了糟糕巩固并且高水位线内容沉积;(3 ) 商业萧条在架斜坡上被限制,由一个异常斜坡坡度或由差错活动被触发;(4 ) turbidite 表建筑群(TSC ) 被归功于到盆地板扇子和斜坡扇子起源,偶尔由混浊水流喂深海洋的存款;(5 ) 沉积飘动在更低的斜坡盆地板发生,并且盖住约 400 km2 的一个区域,在越过海床流动的水流下面被产生;并且(6 ) 在深水区域的中央峡谷表示严肃流动的一种例外的类型碎片流动, turbidite 隧道,和 TSC 的一个协会创作了。它介绍平面 multisegment 和垂直多相的特征。在峡谷与好 petrophysical 性质联系的 Turbidite 能在 QDNB 被当作一个潜在的探索目标。 | SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong TIAN Shanshan ZHANG Cuimei | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 19 |
| 15 | Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro显示文摘Eukaryotic elongation factor-2 kinase (eEF-2K), a negative regulator of protein synthesis, has been shown to play an important role in modulating autophagy and apoptosis in tumor cells under various stresses. In this study, we investigated the regulatory role of eEF-2K in pyroptosis (a new form of programmed necrosis) in doxorubicin-treated human melanoma cells. We found that doxorubicin (0.5-5 μmol/L) induced pyroptosis in melanoma cell lines SK-MEL-5, SK-MEL-28, and A-375 with high expression of DFNA5, but not in human breast cancer cell line MCF-7 with little expression of DFNA5. On the other hand, doxorubicin treatment activated autophagy in the melanoma cells;inhibition of autophagy by transfecting the cells with siRNA targeting Beclin1 or by pretreatment with chloroquine (20 μmol/L) significantly augmented pyroptosis, thus sensitizing the melanoma cells to doxorubicin. We further demonstrated that doxorubicin treatment activated eEF-2K in the melanoma cells, and silencing of eEF-2K blunted autophagic responses, but promoted doxorubicin-induced pyroptotic cell death. Taken together, the above results demonstrate that eEF-2K dictates the cross-talk between pyroptosis and autophagy in doxorubicin-treated human melanoma cells;suppression of eEF-2K results in inhibiting autophagy and augmenting pyroptosis, thus modulating the sensitivity of melanoma cells to doxorubicin, suggesting that targeting eEF-2K may reinforce the antitumor ef?cacy of doxorubicin, offering a new insight into tumor chemotherapy. | Pian Yu Hai-yan Wang Min Tian Ao-xue Li Xi-sha Chen Xin-luan Wang Yi Zhang Yan Cheng | 2019 | Acta Pharmacologica Sinica2019，40，9： | 19 |
| 16 | Protein kinase A-mediated cardioprotection of Tongxinluo relates to the inhibition of myocardial inflammation, apoptosis, and edema in reperfused swine hearts显示文摘 | LI Xiang-dong YANG Yue-jin CHENG Yu-tong DOU Ke-fei TIAN Yi MENG Xian-min | 2013 | Chinese Medical Journal2013，，8： | 18 |
| 17 | Clinical significance of gastrostomy for patients injury percutaneous endoscopic with severe craniocerebral显示文摘 | Tian Yong Du Hanggen Fan Chengpu Wang Cheng Zhang Guojun Chen Li Li Hongyu | 2014 | Chinese Journal of Traumatology2014，17，6： | 18 |
| 18 | The experimental study of interaction between shock wave and turbulence显示文摘The interaction between shock wave and turbulence has been studied in supersonic turbulent mix layer wind tunnel. The interaction between oblique shock wave and turbulent boundary layer and the influence of large vortex in mix layer on oblique shock wave have been observed by NPLS technique. From NPLS image, not only complex flow structure is observed but also time-dependent supersonic flow visualization is realized. The mechanism of interaction between shock wave and turbulence is discussed based on high quality NPLS image. | ZHAO YuXin YI ShiHe HE Lin CHENG ZhongYu TIAN LiFeng | 2007 | Chinese Science Bulletin2007，52，10： | 18 |
| 19 | atural killer cell dysfunction in hepatocellular arcinoma and NK cell-based immunotherapy显示文摘连接肝炎 B 病毒(HBV ) 和丙肝病毒(HCV ) 感染到 hepatocellular 癌(HCC ) 的机制仍然保持大部分未知。生来的杀手(NK ) 房间说明肝淋巴细胞的全部的数字的 25%-50% ,建议 NK 房间起在肝免疫的一个重要作用。在血和 HCC 病人的肿瘤纸巾的 NK 房间的数字断然与他们的幸存和预后被相关。而且,在 HCC 纸巾的一组 NK 联系房间的基因断然与延长幸存被联系。这些事实建议 NK 房间和 HCC 前进强烈被联系。在这评论,我们与长期的 HBV 和 HCV 感染在病人描述反常 NK 房间和他们的功能的缺陷,它贡献 HCC 的前进。然后,我们在 HCC 病人在血和肝 NK 房间的数字和显型基于畸形与 HCC 总结 NK 房间的协会。特别地,代表更低的 cytotoxicity 和损害 cytokine 生产的 NK 房间的疲劳可以为 HCC 的出现用作一个预言者。最后,我们在场在在肝癌症的鼠标模型并且在临床的试用进行的 NK 房间免疫疗法的当前的成就,加亮 chemoimmunotherapy, NK 房间转移,基因治疗, cytokine 治疗和 mAb 治疗怎么在 HCC 治疗改进 NK 房间功能。它是想得到的治疗学的策略将独自或在有另外的治疗的联合是的那 NK 基于房间的 anti-HCC 为 HCC 治疗的大诺言。 | Cheng SUN Hao-yu SUN Wei-hua XIAO Cai ZHANG Zhi-gang TIAN | 2015 | Acta Pharmacologica Sinica2015，36，10： | 18 |
| 20 | Protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis显示文摘AIM: To investigate the protective effects and mechanisms of Baicalin and octreotide on renal injury of rats with severe acute pancreatitis (SAP). METHODS: One hundred and eighty SD rats were randomly assigned to the model group, Baicalin-treated group, octreotide-treated group and sham operation group. The mortality, plasma endotoxin level, contents of blood urea nitrogen (BUN), creatinine (CREA), phospholipase A2 (PLA2), nitrogen monoxide (NO), tumor necrosis factor (TNF)-α, IL-6 and endothelin-1 (ET-1) in serum, expression levels of renal Bax and Bcl-2 protein, apoptotic indexes and pathological changes of kidney were observed at 3, 6 and 12 h after operation. RESULTS: The renal pathological changes were milder in treated group than in model group. The survival at 12 h and renal apoptotic indexes at 6 h were significantly (P < 0.05) higher in treated group than in model group [66.67% vs 100%; 0.00 (0.02)% and 0.00 (0.04)% vs 0.00 (0.00)%, respectively]. The serum CREA content was markedly lower in octreotide-treated group than in model group at 3 h and 6 h (P < 0.01, 29.200 ± 5.710 μmol/L vs 38.400 ± 11.344 μmol/L; P < 0.05, 33.533 ± 10.106 μmol/L vs 45.154 ± 17.435 μmol/L, respectively). The expression level of renal Bax protein was not significantly different between model group and treated groups at all time points. The expression level of renal Bcl-2 protein was lower in Baicalin-treated group than in model group at 6 h [P < 0.001, 0.00 (0.00) grade score vs 3.00 (3.00) grade score]. The Bcl-2 expression level was lower in octreotide-treated group than in model group at 6 h and 12 h [P < 0.05, 0.00 (0.00) grade score vs 3.00 (3.00) grade score; 0.00 (0.00) grade score vs 0.00 (1.25) grade score, respectively]. The serum NO contents were lower in treated groups than in model group at 3 h and 12 h [P < 0.05, 57.50 (22.50) and 52.50 (15.00) μmol/L vs 65.00 (7.50) μmol/L; P < 0.01, 57.50 (27.50) and 45.00 (12.50) μmol/L vs 74.10 (26.15) μmol/L, respectively]. The plasma endotoxin content and serum BUN content (at 6 h and 12 h) were lower in treated groups than in model group. The contents of IL-6, ET-1, TNF-α (at 6 h) and PLA2 (at 6 h and 12 h) were lower in treated groups than in model group [P < 0.001, 3.031 (0.870) and 2.646 (1.373) pg/mL vs 5.437 (1.025) pg/mL; 2.882 (1.392) and 3.076 (1.205) pg/mL vs 6.817 (0.810) pg/mL; 2.832 (0.597) and 2.462 (1.353) pg/mL vs 5.356 (0.747) pg/mL; 16.226 (3.174) and 14.855 (5.747) pg/mL vs 25.625 (7.973) pg/mL; 18.625 (5.780) and 15.185 (1.761) pg/mL vs 24.725 (3.759) pg/mL; 65.10 (27.51) and 47.60 (16.50) pg/mL vs 92.15 (23.12) pg/mL; 67.91 ± 20.61 and 66.86 ± 22.10 U/mL, 63.13 ± 26.31 and 53.63 ± 12.28 U/mL vs 101.46 ± 14.67 and 105.33 ± 18.10 U/mL, respectively]. CONCLUSION: Both Baicalin and octreotide can protect the kidney of rats with severe acute pancreatitis. The therapeutic mechanisms of Baicalin and octreotide might be related to their inhibition of inflammatory mediators and induction of apoptosis. Baicalin might be a promising therapeutic tool for severe acute pancreatitis. | Xi-Ping Zhang Hua Tian Yue-Hong Lai Li Chen Ling Zhang Qi-Hui Cheng Wei Yan Yun Li Qing-Yu Li Qing He Fei Wang | 2007 | World Journal of Gastroenterology2007，13，38： | 17 |
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