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| 1 | Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA81 receptor expression in transient focal cerebral ischemia in rats显示文摘 | Chin-yi CHENG Shan-yu SU Nou-ying TANG Tin-yun HO Wan-yu LO Ching-liang HSIEH | 2010 | Acta Pharmacologica Sinica2010，31，8： | 20 |
| 2 | Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy显示文摘Ischemia occurs in diabetic retinopathy with neuronal loss, edema, glial cell reactivity and oxidative stress. Epacs, consisting of Epac1 and Epac2, are c AMP mediators playing important roles in maintenance of endothelial barrier and neuronal functions. To investigate the roles of Epacs in the pathogenesis of ischemic retinopathy, transient middle cerebral artery occlusion(t MCAO) was performed on Epac1-deficient(Epac1-/-) mice, Epac2-deficient(Epac2-/-) mice, and their wild type counterparts(Epac1+/+ and Epac2+/+). Two-hour occlusion and 22-hour reperfusion were conducted to induce ischemia/reperfusion injury to the retina. After t MCAO, the contralateral retinae displayed similar morphology between different genotypes. Neuronal loss, retinal edema and increase in immunoreactivity for aquaporin 4(AQP4), glial fibrillary acidic protein(GFAP), peroxiredoxin 6(Prx6) were observed in ipsilateral retinae. Epac2-/- ipsilateral retinae showed more neuronal loss in retinal ganglion cell layer, increased retinal thickness and stronger immunostaining of AQP4, GFAP, and Prx6 than those of Epac2+/+. However, Epac1-/- ipsilateral retinae displayed similar pathology as those in Epac1+/+ mice. Our observations suggest that Epac2-deficiency led to more severe ischemic retinopathy after retinal ischemia/reperfusion injury. | LIU Jin YEUNG Patrick Ka Kit CHENG Lu LO Amy Cheuk Yin CHUNG Stephen Sum Man CHUNG Sookja Kim | 2015 | Science China(Life Sciences)2015，58，6： | 12 |
| 3 | Environmental heavy metals and cardiovascular diseases:Status and future direction显示文摘Cardiovascular disease(CVD)and environmental degradation are leading global health problems of our time.Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes,particularly in populations from low-and middle-income countries,where concomitant rapid development occurs.In this review,we 1)assessed the totality,quantity,and consistency of the available epidemiological studies,linking heavy metal exposures to the risk of CVD(including stroke and coronary heart disease);2)discussed the potential biological mechanisms underlying some tantalizing observations in humans;and 3)identified gaps in our knowledge base that must be investigated in future work.An accumulating body of evidence from both experimental and obser-vational studies implicates exposure to heavy metals,in a dose-response manner,in the increased risk of CVD.The limitations of most existing studies include insufficient statistical power,lack of comprehensive assessment of exposure,and cross-sectional design.Given the widespread exposure to heavy metals,an urgent need has emerged to investigate these putative associations of environmental exposures,either independently or jointly,with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations,and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations. | Ai-Min Yang Kenneth Lo Tong-Zhang Zheng Jing-Li Yang Ya-Na Bai Ying-Qing Feng Ning Cheng Si-Min Liu | 2020 | Chronic Diseases and Translational Medicine2020，6，4： | 5 |
| 4 | Composition of common bile duct stones in Chinese patients during and after endoscopic sphincterotomy显示文摘AIM: Endoscopic sphincterotomy (ES) is a well-established therapeutic modality for the removal of common bile duct (CBD) stones. After ES there are still around 10% of patients that experience recurrent CBD stones. The aim of this study is to investigate the composition of CBD stones before and after ES and its clinical significance in Chinese patients.METHODS: From January 1996 to December 2003, 735Veterans General Hospital and stone specimens from 266patients were sent for analysis. Seventy-five patients had recurrent CBD stones and stone specimens from 44patients were sent for analysis. The composition of the stones was analyzed by infrared (IR) spectrometry and they were classified as cholesterol or bilirubinate stones according to the predominant composition. Clinical data were analyzed.RESULTS: In the initial 266 stone samples, 217 (82%)were bilirubinate stones, 42 (16%) were cholesterol stones,3 were calcium carbonate stones, 4 were mixed cholesterol and bilirubinate stones. Patients with bilirubinate stones were significantly older than patients with cholesterol stones (66±13 years vs 56±17 years, P= 0.001). In the 44 recurrent stone samples, 38 (86%) were bilirubinate stones, 3 (7%) were cholesterol stones, and 3 were mixed cholesterol and bilirubinate stones. In 27 patients, bothinitial and recurrent stone specimens can be obtained,23 patients had bilirubinate stones initially and 2 became cholesterol stones in the recurrent attack. In the four patients with initial cholesterol stones, three patients had bilirubinate stones and one patient had a cholesterol stone in the recurrent attack.CONCLUSION: Bilirubinate stone is the predominant composition of initial or recurrent CBD stone in Chinese patients. The composition of CBD stones may be different from initial stones after ES. | Wei-Lun Tsai Kwok-Hung Lai Chiun-Ku Lin Hoi-Hung Chan Ching-Chu Lo Ping-I Hsu Wen-Chi Chen Jin-Shiung Cheng Gin-Ho Lo | 2005 | World Journal of Gastroenterology2005，11，27： | 3 |
| 5 | Endothelial exposure to hypoxia induces Egr-1 expression involving PKCalpha-mediated Bas/Raf-1/ERK1/2 pathway显示文摘 | Lo L W Cheng J J Chiu J J | 2001 | J Cell Physiol2001，188，3： | 2 |
| 6 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 7 | A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices显示文摘 | Gin-Ho Lo Kwok-Hung Lai Jin-Shiung Cheng Mei-Hsiu Chen Hung-Ting Chiang | 2001 | Hepatology2001，，5： | 2 |
| 8 | Clinical application of dip-assisted endoscopic method for nasoenteric feeding in patients with gastroparesis and gastroesophageal wounds显示文摘AIM: To report the clinical experiences in the application of clip-assisted endoscopic method for nasoenteric feeeding in patients with gastroparesis and patients with gastroesophageal wounds, and to compare the efficacy of nasoenteric feeding in these two indications. METHODS: From April 2002 to January 2004, 21 consecutive patients with gastroparesis or gastroesophageal wounds were enrolled and received nasoenteric feeding for nutritional support. A clip-assisted method was used to place the nasoenteric tubes. Outcomes in the two groups were compared with respect to the successful rate of enteral feeding, percentage of recommended energyintake (REI), and complication rates.RESULTS: The gastroparesis group included 13 patients with major bums (n = 7), trauma (n = 2), congestive heart failure (n = 2) and post-surgery gastric stasis syndrome (n = 2). The esophageogastric wound group included eight patients with tracheoesophageal fistula (n = 2) and wound leakage following gastric surgery (n = 6). Two study groups were similar in feeding successful rates (84.6% vs75.0%). There were also no differences in the percentage of REI between groups (79.4% vs 78.6%). Additionally, no complications occurred in any of the study groups. CONCLUSION: Nasoenteric feeding is a useful method to provide nutritional support to most of the patients with gastroparesis who cannot tolerate nasogastric tube feeding and to the cases who need bypass feeding for esophageogastric wounds. | Chung-Jen Wu Ping-I Hsu Gin-Ho Lo Chang-Bih Shie Ching-Chu Lo E-Ming Wang Chiun-Ku Lin Wen-Chi Chen Lung-Chin Cheng Hsien-Chung Yu Yi-Chun Chan Kwok-Hung Lai | 2005 | World Journal of Gastroenterology2005，11，24： | 2 |
| 9 | Extensive contact tracing and screening to control the spread of vancomycin-resistant Enterococcus faecium ST414 in Hong Kong显示文摘 | CHENG Vincent Chi-chung TAI Josepha Wai-ming NG Modissa Lai-ming CHAN Jasper Fuk-woo WONG Sally Cheuk-ying LI Iris Wai-sum CHUNG Hon-ping LO Wai-kei YUEN Kwok-yung HO Pak-leung | 2012 | Chinese Medical Journal2012，，19： | 2 |
| 10 | 显示文摘 | Cheng JS Lai KH Lo GH | 2000 | Zhonghua Yi Xue Za Zhi (Taipei)2000，63，9： | 1 |
| 11 | Endothelial exposure to hypoxia induces Egr-1 expression involving PKC-mediated Ras/ Raf-1/ERK1/2 pathway显示文摘 | Lo LW Cheng JJ Chiu JJ | 2001 | J Cell Physiol2001，188，： | 1 |
| 12 | Emergency banding ligation versus sclertherapy for the control of active bleeding from esophageal varices 显示文摘 | Lo GH Lai KH Cheng JS | 1997 | Hepatology1997，25，5： | 1 |
| 13 | Admission hyperglycemia predicts poorer short‐ and long‐term outcomes after primary percutaneous coronary intervention for ST ‐elevation myocardial infarction显示文摘 | Pei‐Chi Chen Su‐Kiat Chua Huei‐Fong Hung Chung‐Yen Huang Chiu‐Mei Lin Shih‐Ming Lai Yen‐Ling Chen Jun‐Jack Cheng Chiung‐Zuan Chiu Shih‐Huang Lee Huey‐Ming Lo Kou‐Gi Shyu | 2014 | J Diabetes Invest2014，，1： | 1 |
| 14 | Antibiotic susceptibility pattern and erythromycin resistance mechanisms in beta- hemolytic group G Streptococcus dysgalaetiae subspecies equisimilis isolates from central Taiwan显示文摘 | Lo H H Nien H H Cheng Y Y | 2014 | J Microbiol Immunol Infect2014，，： | 1 |
| 15 | Effect of somatostatin on the sphincter of oddi in patients with acute non-biliary pancreatitis 显示文摘 | Lai KH Lo GH Cheng JS | 2002 | Pancreatology2002，2，5： | 1 |
| 16 | Genotype and phenotype analysis of patients with sporadic paralysis显示文摘 | SUNG CC CHENG CJ LO YF | | 0，，04： | 1 |
| 17 | A tightly regulated and reversibly inducible siRNA expression system for conditional RNAi-mediated gene si1encing in mammalian cells显示文摘 | Wu RH Cheng TL Lo SR | 2007 | The Journal of Gene Medicine2007，9，7： | 1 |
| 18 | Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips显示文摘 | Xiaohui Zeng Ka-Wing Cheng Yegang Du Ricky Kong Clive Lo Ivan K. Chu Feng Chen Mingfu Wang | 2010 | Food Chemistry2010，，2： | 1 |
| 19 | Activation of muopioid receptors improves insulin sensitivity in obese Zucker rats显示文摘 | Tzeng TF Lo CY Cheng JT | 2007 | Life Sci2007，80，： | 1 |
| 20 | Survival of CAPD patients in a center using 2-liter exchanges as standard regimen显示文摘 | Lo WK Jiang Y Cheng SW | 1996 | Perit Dial Int1996，16，1： | 1 |
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