|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age and menopausal status are important factors influencing the serum human epididymis secretory protein 4 level:a prospective cross-sectional study in healthy Chinese people显示文摘Background::Human epididymis secretory protein 4(HE4)is a new ovarian cancer biomarker.The factors influencing HE4 levels are not clear,and the reference data in China are limited.Here,we aim to evaluate the effects of menopause and age on HE4 levels and to provide a possible reference value for HE4 in healthy Chinese people.Methods::A total of 2493 healthy females aged 40 years or older were recruited from March 2013 to March 2017 with the cooperation of four medical institutions across Beijing,China.The serum levels of HE4 and cancer antigen 125(CA125)were measured by enzyme-linked immunosorbent assay.The Wilcoxon rank-sum test of variance and a stratified analysis were used to analyze the relationships among age,menopausal status,and levels of HE4 or CA125.Confidence intervals(5%-95%)were determined for reference ranges in different populations.Results::There was a statistically significant difference in median HE4 levels between the post-menopausal(n=2168)and premenopausal groups(n=325)(36.46 vs.24.04 pmol/L,Z=-14.41,P<0.001).HE4 increased significantly with age in the post-menopausal groups(H=408.18,P<0.001)but not in the pre-menopausal subjects(Z=-0.43,P=0.67).The upper 95th percentile of HE4 levels were 44.63 pmol/L for pre-menopausal women,78.17 pmol/L for post-menopausal women,and 73.3 pmol/L for all women.In the post-menopausal population,the HE4 reference ranges were 13.15 to 47.31,14.31 to 58.04,17.06 to 73.51,24.50 to 115.25,and 35.71 to 212.37 pmol/L for different age groups from forty divided by decade.The CA125 level was affected mainly by menopausal status and not age.Conclusions::Menopausal status and age were both important factors influencing the level of HE4,and age affected HE4 levels mainly in post-menopausal women.The HE4 level was higher in the post-menopausal population than in the pre-menopausal population and increased with age. | Hong-Yan Cheng Lin Zeng Xue Ye Rui-Qiong M a Zhi-Jian Tang Hong-Ling Chu Yi-M ing Zhao Li-Rong Zhu Yu-Nong Gao Xiao-Hong Chang Heng Cui | 2020 | Chinese Medical Journal2020，，11： | 6 |
| 2 | Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemia brain injury 显示文摘 | Cheng Y Deshmukh M D'Costa A | 1998 | J Clin Invest1998，101，9： | 2 |
| 3 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 4 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 5 | Caspase inbibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxicischenmic brain injury 显示文摘 | Cheng Y Deshmukh M Deosta A | 1998 | J clin invest1998，101，9： | 1 |
| 6 | Janus kinases and their role in growth and disease显示文摘 | Aringer M Cheng A Nelson JW | 1999 | Life Sci1999，64，24： | 1 |
| 7 | Pressure and force fluctuations on isolated roughened circular cylinders of finite height in boundary layer flows 显示文摘 | KAREEM A CHENG C M | 1999 | Journal of Fluids and Structures1999，13，78： | 1 |
| 8 | Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury显示文摘 | Cheng Y Deshmukh M D'Costa A | 1998 | J Clin Invest1998，101，9： | 1 |
| 9 | Bayesian wavelet shrinkage with edge detection for SAR image despeckling显示文摘 | Dai M Peng Cheng and Chan A K | 2004 | IEEE Transactions on Geoscience and Remote Sensing2004，42，8： | 1 |
| 10 | The Compliance Method for Measurement of Near Surface Residual Stresses-application and Validation for Surface Treatment by Laser and Shotpeening显示文摘 | Cheng W Finnie I Gremaud M Rosselet A Streit R D | 1994 | ASME Journal of Engineering Material and Technology1994，116，： | 1 |
| 11 | Dislocation model for aseismic crustal deformation at Hollister, California显示文摘 | MATSU'URA M JACKSON D CHENG A | 1986 | J Geophys Res1986，91，12： | 1 |
| 12 | Dislocation Model for Aseismic Crustal Deformation,at Hollister,California显示文摘 | Matsu'ura M Jackson D D Cheng A | 1986 | J Geophys Res1986，91，12： | 1 |
| 13 | Electron microscopic studies of the morphogenesis of duck enteritis virus显示文摘 | Yuan G P Cheng A C Wang M S | 2005 | Avian Dis2005，49，1： | 1 |
| 14 | The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated sig- nals 显示文摘 | Chen M Cheng A Chen YQ | 1997 | proc Natl Acad Set USA1997，94，： | 1 |
| 15 | Yogurts from skim milk- whey protein concentrate blends显示文摘 | Cheng L J Augustina M A Clarke P T | 2000 | Austealian Journal of Dairy Technology2000，，55： | 1 |
| 16 | High peak power pulse amplification in large core Yb-doped fiber amplifiers显示文摘 | Galvanauskas A Cheng M Y Hou K C | 2007 | IEEEJ Sel Top Quant2007，13，3： | 1 |
| 17 | Mechanical and electrical properties of a MWNT/epoxy composite 显示文摘 | Allaoui A Bai S Cheng H M | 2002 | Composites Science and Technology2002，62，15： | 1 |
| 18 | Detectability and output feedback stabilizability of nonlinear networked control systems 显示文摘 | SAVKIN A V CHENG T M | 2007 | IEEE Transactions on Automatic Control2007，52，4： | 1 |
| 19 | Distribution of volatile sulfur containing products during fixed bed pyrolysis and gasification显示文摘 | Furimsky E Palamer A D Cheng M | 1991 | Can J Chem Eng1991，69，： | 1 |
| 20 | Somatic hybridization between common wheat and Italian ryegrass 显示文摘 | Cheng A X Xia G M | 2004 | Plant Science2004，166，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员