3篇
您的检索式：作者名="Chenfeng Liang"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Application of Langlois' reagent(NaSO_(2)CF_(3)) in C–H functionalisation显示文摘The process of selectively introducing a CF_(3) group into an organic molecule using inexpensive, stable, and solid sodium trifluoromethanesulfinate has rapidly advanced in recent years to become an eco-friendly method used by organic chemists to synthesize various natural and bioactive molecules. This review focuses on advances made within the last five years regarding C-H functionalisation, namely thermochemical C(sp^(2))-H (thio)trifluoromethylations, photochemical C(sp^(2))-H trifluoromethylations, and electrochemical C(sp^(2))-H trifluoromethylations, using Langlois’ reagent (NaSO_(2)CF_(3)). | Jiabin Shen Jun Xu Lei He Chenfeng Liang Wanmei Li | 2022 | Chinese Chemical Letters2022，33，3： | 1 |
| 2 | mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a显示文摘Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts,blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors.Due to these adverse effects,preosteoblast senescence is a crucial target for the treatment of age-related bone loss;however,the underlying mechanism remains unclear.We found that mTORC1 accelerated preosteoblast senescence in vitro and in a mouse model.Mechanistically,mTORC1 induced a change in the membrane potential from polarization to depolarization,thus promoting cell senescence by increasing Ca^(2+)influx and activating downstream NFAT/ATF3/p53 signaling.We further identified the sodium channel Scn1a as a mediator of membrane depolarization in senescent preosteoblasts.Scn1a expression was found to be positively regulated by mTORC1 upstream of C/EBPα,whereas its permeability to Na^(+)was found to be gated by protein kinase A(PKA)-induced phosphorylation.Prosenescent stresses increased the permeability of Scn1a to Na^(+)by suppressing PKA activity and induced depolarization in preosteoblasts.Together,our findings identify a novel pathway involving mTORC1,Scn1a expression and gating,plasma membrane depolarization,increased Ca^(2+)influx and NFAT/ATF3/p53 signaling in the regulation of preosteoblast senescence.Pharmaceutical studies of the related pathways and agents might lead to novel potential treatments for agerelated bone loss. | Ajuan Chen Jian Jin Shasha Cheng Zezheng Liu Cheng Yang Qingjing Chen Wenquan Liang Kai Li Dawei Kang Zhicong Ouyang Chenfeng Yao Xiaochun Bai Qingchu Li Dadi Jin Bin Huang | 2022 | Bone Research2022，10，2： | 0 |
| 3 | Rapid alkenylation of quinoxalin-2(1H)-ones enabled by the sequential Mannich-type reaction and solar photocatalysis显示文摘Herein,a rapid alkenylation of quinoxalin-2(1H)-ones enabled by a combination of Mannich-type reaction and solar photocatalysis is demonstrated.A wide range of functional groups are compatible,affording the corresponding products in moderate-to-good yields.Control experiments illustrate that the in situ generated^(1)O_(2)plays a central role in this reaction.This green and efficient strategy provides a practical solution for the synthesis of potentially bioactive compounds that containing a 3,4-dihydroquinoxalin-2(1H)-one structure. | Lin Huang Jun Xu Lei He Chenfeng Liang Yani Ouyang Yongping Yu Wanmei Li Pengfei Zhang | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员