2篇
您的检索式：作者名="Chenchen Tu"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization显示文摘Matrix vesicles(MVs)have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium and phosphorus content.However,the role of MVs in the progression of osteoporosis is poorly understood.Here,we report that annexin A5,an important component of the matrix vesicle membrane,plays a vital role in bone matrix homeostasis in the deterioration of osteoporosis.We first identified annexin A5 from adherent MVs but not dissociative MVs of osteoblasts and found that it could be sharply decreased in the bone matrix during the occurrence of osteoporosis based on ovariectomized mice.We then confirmed its potential in mediating the mineralization of the precursor osteoblast lineage via its initial binding with collagen type I to achieve MV adhesion and the subsequent activation of cellular autophagy.Finally,we proved its protective role in resisting bone loss by applying it to osteoporotic mice.Taken together,these data revealed the importance of annexin A5,originating from adherent MVs of osteoblasts,in bone matrix remodeling of osteoporosis and provided a new strategy for the treatment and intervention of bone loss. | Guanyue Su Demao Zhang Tiantian Li Tong Pei Jie Yang Shasha Tu Sijun Liu Jie Ren Yaojia Zhang Mengmeng Duan Xinrui Yang Yang Shen Chenchen Zhou Jing Xie Xiaoheng Liu | 2023 | Bone Research2023，11，4： | 0 |
| 2 | Clamping effect driven design and fabrication of new infrared birefringent materials with large optical anisotropy显示文摘Infrared(IR)birefringent materials with large optical anisotropy and wide transparency range are important for efficient light manipulation in various IR optical devices.Herein,two new IR birefringent materials AMgGeSe_(3)(A=Li,Na)with large optical anisotropy were rationally designed by a rigid octahedron and flexible dimer combined strategy and fabricated in experiment.The introduction of rigid[LiSe_(6)]/[NaSe_(6)]and[MgSe_(6)]octahedra effectively regulates the geometry and arrangement of the flexible[Ge2Se6]dimers,resulting in the birefringence as large as 0.334@1,064 nm in LiMgGeSe_(3) and 0.445@1,064 nm(the largest one in the reported[Ge_(2)Se_(6)]dimer-contained selenides)in NaMgGeSe_(3).Density functional theory(DFT)calculations and statistical analyses highlight the influence of polarizability anisotropy,density,arrangement of units,as well as layer distance on birefringence.The results indicate that AMgGeSe_(3)(A=Li,Na)crystals are the promising IR birefringent materials and it gives an insight into the exploration of new IR birefringent materials with large birefringence based on the clamping effect from rigid groups. | Linan Wang Chenchen Tu Hongbo Gao Jiazheng Zhou Hongshan Wang Zhihua Yang Shilie Pan Junjie Li | 2023 | Science China Chemistry2023，66，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员