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	题名	作者	年代	出处	被引量
1	Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan显示文摘The aim of this study was to improve the dissolution rate of the poorly soluble drug valsartan by delivering the drug as a liquisolid compact.Liquisolid compacts were prepared using propylene glycol as solvent,Avicel PH102 as carrier,and Aerosil 200 as the coating material.The crystallinity of the newly formulated drug and the interaction between excipients was examined by X-ray powder diffraction and Fourier-transform infrared spectroscopy,respectively.The dissolution studies for the liquisolid formula-tion and the marketed product were carried out at different pH values.The results showed no change in the crystallinity of the drug and no interaction between excipients.The dissolution efficiency of valsartan at 15 min was increased from 4.02% for plain drug and 13.58% for marketed product to 29.47% for the liquisolid formulation.The increase in the dissolution rate was also found to be significant compared to the marketed product at lower pH values,simulating the gastric environment where valsartan is largely absorbed.The liquisolid technique appears to be a promising approach for improving the dissolution of poorly soluble drugs like valsartan.	Chella Naveen Nalini Shastri Rama Rao Tadikonda	2012	Acta Pharmaceutica Sinica B2012，2，5：	4
2	Effects of shear stress on 3-D human mesenchymal stem cell construct development in a perfusion bioreactor system: Experiments and hydrodynamic modeling显示文摘	Zhao F Chella R Ma T	2007	Biotechnol Bioeng2007，96，3：	1
3	Erlotinib after Failure of Gefitinib in Patients with Advanced Non-small Cell Lung Cancer Previously Responding to Gefitinib显示文摘	Enrico Vasile Carmelo Tibaldi Antonio Chella Alfredo Falcone	2008	Journal of Thoracic Oncology2008，，8：	1
4	Preopreative chemotherapy for stage ⅢA(N2) non-small cell lung cancer显示文摘	Chella A Lucchi M Ribochini A	1995	Euur J Surg Oncol1995，21，：	1
5	Combined Nd- YAG laser/HDR hrachytherapy versus Nd-YAG laser only in malignant central airway involvement :a prospective ran- domized study显示文摘	Chella A Ambrogi MC Ribechini A	2000	Lung Cancer2000，27，3：	1
6	The management of malignant pericardial effusions using permanently implanted devices显示文摘	Melfi FM Menconi GF Chella A	2002	Eur J Cardiothorac Surg2002，21，2：	1
7	Mapping myasthenia gravis-associated T cell epitopes on human acetylcholineReceptors in HLA transgenic mice显示文摘	Huan Yang Elzbieta Goluszko Chella David	2002	J Clin Invest2002，109，8：	1
8	Design and analysis of hydro generator ventilation system using experimental and CFD 显示文摘	CHELLA Rao G GOVINDA Rajulu K GUNABUSHANARN N	2011	Proceedings of World Academy of Science Engineering and Technology2011，75，3：	1
9	Alcoholism is a disinhibitory disorder: neurophysiological evidence from a Go/No-Go task 显示文摘	CHELLA K BERNICE P KEVIN A J	2005	Biological Psychology2005，69，3：	1
10	Facies and sequence stratigraphy of a Late Barremian wave-dominated deltaic deposit, Agadir Basin, Morocco 显示文摘	Nouidar M Chella E H	2002	Sedimentary Geology2002，150，3：	1
11	Treatment of malignant pleural effusion by percutaneous catheter drainage and chemical pleuredesis 显示文摘	Chella A Ribechini A Dini P	1994	Minerva Chit1994，49，11：	1
12	Erlotinib after failure of gefitinib in patients with advanced non-small cell lung cancer previously responding to gefitinib显示文摘	Vasile E Tibaldi C Chella A	2008	J Thorac Oncol2008，3，8：	1
13	Surgery in the management of small cell lung cancer 显示文摘	Lucchi M Mussi A Chella A	1997	Eur J Cardiothorac Surg1997，12，5：	1
14	Upregulation of the immune system in primary hypercholesterolaemia:effect of atorvastatin therapy显示文摘	DSampietro T Bigazzi F Rossi Gal Pino B Puntoni MR Sbrana F Chella E	2005	J Intern Med2005，257，6：	1
15	Prevalence of peripheral vascular disease and its association with carotid intima-media thickness and arterial stiffness in type 2 diabetes:The Chennai Urban Rural Epidemiology Study (CURES 111)显示文摘	Pradeepa R Chella S Surendar J	2014	Diab Vasc Dis Res2014，11，：	1
16	A comprehensive approach to clustering of expressed human gene sequence: The sequence tag alignmenet and consensus knowledge base显示文摘	Robert TM Alan GC Chella G	1999	Genome Research1999，9，11：	1
17	Conceptual spaces for computer vision representations 显示文摘	Chella A Frixione M Gaglio S	2001	Artificial Intelligence Review2001，16，2：	1
18	Surgery in the management of small cell lung cancer显示文摘	Lucci M Mussi A Chella A	1997	Eur J Cardiothorac Surg1997，12，：	1
19	On bring it about显示文摘	CHELLAS B F	1995	Journal of Philosophical Logic1995，24，：	1
20	Second-line chemotherapy with a modified schedule of docetaxel in elderly patients with advanced-stage non-small-cell lung cancer 显示文摘	Tibaldi C Bemardini I Chella A	2006	Clin Lung Cancer2006，7，6：	1

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