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| 1 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 4 | The Holonic Enterprise and Theory Emergence: On Emergent Features of Self-Organization in Distributed Virtual Agents显示文摘 | Mihaela U Este R A | 2004 | International Journal Cybernetics and Human Knowing2004，11，1： | 1 |
| 5 | Load rating versus reliabilityanalysis显示文摘 | Estes A C Frangopol D M | 2005 | Journal of Structural Engineering2005，131，5： | 1 |
| 6 | A method for meta-analysis of molecular association studies显示文摘 | Thakkinstian A McElduff P D~Este C | 2005 | Stat Med2005，24，： | 1 |
| 7 | RNA interference of HIV replication显示文摘 | Martinez M A Cohet B Este J A | 2002 | Trends Immunology2002，23，12： | 1 |
| 8 | On the Stability of the Information Carried by Traffic Flow Features at the Packet Level显示文摘 | ESTE A GRINGOLI F SALGARELLI L | 2009 | ACM SIGCOMM Computer Communication Review2009，39，3： | 1 |
| 9 | Evolutionary traceresidues in Noroviruses : importance in receptor binding, antigenicity, virion assembly, and strain diversity 显示文摘 | Chakravarty S Hutson A M Estes M K | 2005 | J Virol2005，79，1： | 1 |
| 10 | Investigating the factors that diminish the barriers to university - industry collaboration 显示文摘 | I BRUNEEL J D' ESTE P SALETER A | 2010 | Research Policy2010，，39： | 1 |
| 11 | Powering the Fiber Loop Optically-a Cost Analysis显示文摘 | BANWELL T C ESTES R C REITH L A | 1993 | Journal of Light Wave Technology1993，11，3： | 1 |
| 12 | Correlation of Sauter mean diameter and critical heat flux for spray cooling of small surfaces显示文摘 | ESTES K A MUDAWAR I | 1995 | International Journal of Heat & Mass Transfer1995，38，16： | 1 |
| 13 | Through sonographic oocyte retrieval during in vitro fertilization produces results similar to ovarian wedge resection in patients with elomiphene citrate polycystic ovarian syndrome显示文摘 | Branigan EF Estes A Walker K | 2006 | Am J Obstet Gynecol2006，194，6： | 1 |
| 14 | Thorough sonographic oocyte retrieval during in vitro fertilization produces results similar to ovarian wedge resection in patients with clomiphene citrate resistant polycystic ovarian syndrome显示文摘 | BRANIGAN E F ESTES A WALKERK | 2006 | Am J Obstet Gynecol2006，194，6： | 1 |
| 15 | Support Vector Machines for TCP Traffic Classification 显示文摘 | ESTE A GRINGOLI F SALGARELLI L | 2009 | Computer Networks2009，53，14： | 1 |
| 16 | Support vector machines for TCP trafficclassification显示文摘 | Este A Gringoli F Salgarelli L | 2009 | Computer Networks2009，53，14： | 1 |
| 17 | Ion transport in plant cell and tissues显示文摘 | (S)EST(A)K Z | 1976 | Biologia Plantarum1976，18，： | 1 |
| 18 | Sudden cardiac death in athletes显示文摘 | Link M S Mark Estes N A 3rd | 2008 | Prog Cardiovasc Dis2008，51，： | 1 |
| 19 | Engineered antifouling microtopgraphies -correlating wettability with cell attachment 显示文摘 | CARMAN M L ESTES T G FEINBERG A W | 2006 | Biofouling2006，22，12： | 1 |
| 20 | Localization and quantification of carbonic anhydrase activity in the symbiotic scyphozoan Cassiopea acamachana 显示文摘 | Estes A M Kempf S C Henry R P | 2003 | Bio- logical Bulletin2003，204，3： | 1 |
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