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| 1 | Red carbon dots as label-free two-photon fluorescent nanoprobes for imaging of formaldehyde in living cells and zebrafishes显示文摘Direct,in situ selective detection of intracellular formaldehyde(FA)is of great significance for understanding its function in FA-related diseases.Herein,red carbon dots(RCD)are reported as label-free two-photon fluorescent nanoprobes for detecting and imaging of FA.Upon addition of FA,the-NH2 groups of RCD could quickly and specially react with aldehydes to form Schiff base and then the strong fluorescence of RCD with blue-shift emission is recovery due to the destruction of the hydrogen bond interaction between RCD and water.In addition,the nanoprobes exhibit outsta nding photo stability,rapid response(<1 min),high sensitivity(~9.9μmol/L)and excellent selectivity toward FA over other aldehyde group compounds.Notably,owing to the good cell-membrane permeability and biocompatibility,as well as the large two-photon absorption cross-section,the as-prepared RCD can be used as label-free nanoprobes for selectively detecting and imaging FA in living cells and zebrafishes through one-photon and two-photon excitation.Moreover,RCD could stain the tissue of zebrafishes at depths interval of up to 240μm under two-photon excitation.This research implied that RCD are promising tools for directly and in situ imaging FA in vivo,thus providing critical insights into FA-related pathophysiological processes. | Hong Wang Jing Wei Chonghua Zhang Yuan Zhang Yubin Zhang Lin Li Changmin Yu Peisheng Zhang Jian Chen | 2020 | Chinese Chemical Letters2020，31，3： | 3 |
| 2 | Recent progress in small molecule fluorescent probes for nitroreductase显示文摘Nitroreductase(NTR) is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia,which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption and supply, can result in NTR overexpression. Using either nicotinamide adenine dinucleotide(NADH) or nicotinamide adenine dinucleotide phosphate(NADPH) as a source of reducing equivalents, NTR can catalyze the reduction of nitroaromatic compounds to the corresponding amines.Based on this reduction mechanism, NTR can be applied not only in the bioremediation and degradation of organic nitrogen compounds, but also in the development of NTR-targeted fluorescent probes to detect the hypoxic status of cancer cells. This review aims to provide a summary of the progress in fluorescent probes for NTR in recent years and elucidate the main fluorescent mechanisms that have been applied to design probes. | Wenjing Qin Chenchen Xu Yanfei Zhao Changmin Yu Sheng Shen Lin Li Wei Huang | 2018 | Chinese Chemical Letters2018，29，10： | 2 |
| 3 | Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics显示文摘Sweat contains a broad range of critical biomarkers including ions,small molecules,and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression.Wearable sweat biosensors enable the collection and analysis of sweat in situ,achieving real-time,continuous,and noninvasive monitoring of human biochemical parameters at the molecular level.This review summarizes the physiological/pathological information of sweat and wearable sweat biosensors.First,the production of sweat pertaining to various electrolytes,metabolites,and proteins is described.Then,the compositions of the wearable sweat biosensors are summarized,and the design of each subsystem is introduced in detail.The latest applications of wearable sweat biosensors for outdoor,hospital,and family monitoring are highlighted.Finally,the review provides a summary and an outlook on the future developments and challenges of wearable sweat biosensors with the aim of advancing the field of wearable sweat monitoring technology. | Wenhui Ji Jingyu Zhu Wanxia Wu Nanxiang Wang Jiqing Wang Jiansheng Wu Qiong Wu Xuewen Wang Changmin Yu Gaofeng Wei Lin Li Fengwei Huo | 2021 | Research2021，，1： | 1 |
| 4 | Wearable Sweat Biosensors Refresh Personalized Health/Medical Diagnostics显示文摘Sweat contains a broad range of critical biomarkers including ions,small molecules,and macromolecules that may indirectly or directly reflect the health status of the human body and thereby help track disease progression.Wearable sweat biosensors enable the collection and analysis of sweat in situ,achieving real-time,continuous,and noninvasive monitoring of human biochemical parameters at the molecular level.This review summarizes the physiological/pathological information of sweat and wearable sweat biosensors.First,the production of sweat pertaining to various electrolytes,metabolites,and proteins is described.Then,the compositions of the wearable sweat biosensors are summarized,and the design of each subsystem is introduced in detail.The latest applications of wearable sweat biosensors for outdoor,hospital,and family monitoring are highlighted.Finally,the review provides a summary and an outlook on the future developments and challenges of wearable sweat biosensors with the aim of advancing the field of wearable sweat monitoring technology. | Wenhui Ji Jingyu Zhu Wanxia Wu Nanxiang Wang Jiqing Wang Jiansheng Wu Qiong Wu Xuewen Wang Changmin Yu Gaofeng Wei Lin Li Fengwei Huo | 2022 | Research2022，，1： | 1 |
| 5 | Mitochondria-targeted fluorescent probe based on vibration-induced emission for real-time monitoring mitophagy-specific viscosity dynamic显示文摘Directly monitoring mitophagy-specific viscosity dynamic in living cells is of great significance but remains challenging.Herein,this study reported a novel mitochondria-targeted fluorescent probe DPACDY based on vibration-induced emission(VIE)for monitoring viscosity changes during mitochondrial autophagy.This probe contained N,N’-diphenyl-dihydrodibenzo[a,c]phenazine(DPAC)as the VIE core and two positively charged pyridinium moieties for mitochondria anchoring.As the ambient viscosity increased,the vibration of DPAC-DY could be hindered,and subsequently resulting in the enhancement of fluorescence emission.In vitro and intracellular experiments indicated that the probe DPAC-DY showed highly sensitive response to viscosity due to VIE mechanism.Importantly,by virtue of this probe,in situ and real-time visualization of the specific viscosity dynamics during the mitochondrial autophagy process was achieved.Thus,this work provides a novel strategy for VIE-based viscosity response sensors applied to specific organelles and offers a platform for in-depth study of mitochondrial viscosity-related diseases. | Shuangxi Wang Bicong Zhou Na Wang Changmin Yu Naidi Yang Jian Chen Qiong Wu Chengwu Zhang Lin Li Wei Huang | 2020 | Chinese Chemical Letters2020，31，11： | 1 |
| 6 | Impact of subtropical climate on frequency of ambulance use for trauma patients in a coastal area of China显示文摘 | Yuqiang Chen Yucheng Lai Jiajie Ke Yuefeng Chen Yuling Xu Yuqin Ma Jiayin Yuan Tian Liang Pengzhan Mai Changmin Lin Yang Xie Keng Huang | 2015 | Chinese Journal of Traumatology2015，18，3： | 0 |
| 7 | Ultrasensitive detection of IgE levels based on magnetic nanocapturer linked immunosensor assay for early diagnosis of cancer显示文摘Rapid and accurate detection of immunoglobulin E(Ig E) in serum and reduction of serum dosage are of great significance for clinical detection. Herein, we described a rapid magnetic separation of Ig E from patient serum based on Fe3 O4@Si O2-NTA@026 sdab as the capture probe and multiple horseradish peroxidase(HRP)-labeled antibodies linked gold nanoparticles(Au NPs) as chemiluminescence(CL) signal amplifier for ultrasensitive detection of total Ig E. Results showed that the limit of detection of our immunosensor system in serum samples was 0.03 k U/L, which is lowest in comparison with current methods, and far lower than that of Immuno CAP for Ig E detection(0.1 k U/L). Furthermore, our immunosensor possessed satisfied repeatability and accuracy, as well as good stability. In comparison with the Immuno CAP for the quantitative detection of Ig E, highly consistent results were achieved in 20 serum samples. Specially, this method was also successfully utilized for assessing the Ig E traces in breast cancer patients,which provides a new idea for the diagnosis of early cancer. Therefore, we believe that such versatile immunosensor will offer an alternative method for the on-site monitoring and determination of various Ig E-related diseases. | Yongxin Liu Mengda Cao Zhongxi Huang Changmin Yu Naidi Yang Qiong Wu Liang Shi Wenjie Duan Yi Zhu Jifu Wei Lin Li Wei Huang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 8 | Rational design of nanocarriers for mitochondria-targeted drug delivery显示文摘Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable.Numerous studies have been conducted on the treatment of mitochondria-related diseases;however,further improvements are required to develop more effective drug delivery methods.Herein,we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers,and discuss the different strategies of available nanocarriers for targeting mitochondria.We also highlight the advantages and disadvantages of various carrier systems that are currently in use.Finally,perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed. | Lihua Huang Zonghao Sun Qian Shen Zhongxi Huang Shuangxi Wang Naidi Yang Gongqiang Li Qiong Wu Wei Wang Lin Li Changmin Yu | 2022 | Chinese Chemical Letters2022，33，9： | 0 |
| 9 | Older adults’social participation and social relationship and association with partner’s cognition:a latent profile analysis显示文摘Older adults’social participation and social relationship may be affected by their partners’cognitive function.In 3,722 cognitively intact married/partnered Health and Retirement Study respondents,latent profile analysis identified three social participation profiles(Limited overall social participation(prevalence:69%);Frequent volunteer participation(10%);Frequent non-volunteer participation(21%)),and three social relationship profiles(Social support from all relationships(68%);Mixed social support and strain from all relationships(18%);Social strain from partner with support from other relationships(14%)).Spouse/partner’s cognition was not significantly associated with social participation profiles.Impaired cognition in spouses/partners increased older adults’likelihood of perceiving social strain from their partners with support from other relationships.Frequent volunteer and non-volunteer participation and perceiving social support from all relationships predicted better self-rated health and lower odds of depressive symptoms.These findings highlight the need of community programs that promote social connectedness for older adults living with cognitively impaired spouses/partners. | Yiyang Yuan Changmin Peng Yan Lin Shan Qu | 2023 | China Population and Development Studies2023，7，4： | 0 |
| 10 | Dynamic expression of Wnt signaling molecules and stem-cell marker CK15 in the growth cycle of rat whisker hair follicles显示文摘Objective To investigate the distribution and dynamic changes of both Wnt signaling molecules and CK15 throughoutthe three phases of the follicular cycle,and to explore the relationship between Wnt/β-catenin signaling and CK15 in rat whisker hair follicle(HF)growth cycles.Methods Hematoxylin-Eosin(HE)and immunofluorescence stains were used to characterize the expression patterns,including sites and levels of some representative proteins of both canonical and non-canonical Wnt signaling molecules,as well as HF epithelial stem cell marker CK15.Results The expression patterns of bothβ-catenin and Wnt5a were correlated with that of CK15.CK15 was only expressed in anagen.In catagen,β-catenin showed a massive depletion while Wnt5a noticeably increased.In telogen,high level expression ofβ-catenin and low level of Wnt5a were detected.Wnt10b and TCF3 were detected during the entire HF growth cycle.Conclusion These results suggest that Wnt5a is associated with the transition of anagen-catagen phase,accompanied by broad deletion ofβ-catenin and loss of CK15.WntlOb is important for the maintenance of HF activity and is related to the telogenanagen transition. | 陈泽鑫 Lin Chun Huang Jia Zeng Qingxiang Lin Jiali Lin Yingwen Yuan Yanping Cai Bozhi Lin Changmin | 2017 | 中国组织化学与细胞化学杂志2017，26，1： | 0 |
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