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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 3 | Intense exercise can cause excessive apoptosis and synapse plasticity damage in rat hippocampus through Ca2+ overload and endoplasmic reticulum stress-induced apoptosis pathway显示文摘 | Ding Yi Chang Cunqing Xie Lan Chen Zhimin Ai Hua | 2014 | Chinese Medical Journal2014，，18： | 15 |
| 4 | Estrogen reduces CCL_4-induced liver fibrosis in rats显示文摘AIM: Chronic liver diseases, such as fibrosis or cirrhosis,are more common in men than in women. This genderdifference may be related to the effects of sex hormones onthe liver. The aim of the present work was to investigatethe effects of estrogen on CCL4-induced fibrosis of the liverin rats.METHODS: Liver fibrosis was induced in male, female andovariectomized rats by CCL4 administration. All the groupswere treated with estradiol(1 mg/kg) twice weekly. Andtamoxifen wasgiven to male fibrosis model. At the end of 8weeks, all therats were killed to study serum indicators andthe livers.RESULTS: Estradiol treatment reduced aspartateaminotransferase(AST), alanine aminotransferase (ALT),hyaluronic acid(HA) and type IV collagen(CIV) in sera,suppressed hepatic collagen content, decreased the areas ofhepatic stellate cells (HSC) positive for α-smooth muscle actin(α-SMA), and lowered the synthesis of hepatic type I collagensignificantly in both sexes and ovariectomy fibrotic rats inducedby CCL4 administration. Whereas, tamoxifen had the oppositeeffect. The fibrotic response of the female liver to CCL4treatment was significantly weaker than that of male liver.CONCLUSION: Estradiol reduces CCL4-induced hepaticfibrosis in rats. The antifibrogenic role of estrogen in theliver may be one reason for the sex associated differencesin the progression from hepatic fibrosis to cirrhosis. | Jun-Wang Xu Jun Gong Xin-Ming Chang Jin-Yan Luo Lei Dong Zhi-Ming Hao Ai Jia Gui-Ping Xu | 2002 | World Journal of Gastroenterology2002，8，5： | 14 |
| 5 | Up-regulation of visfatin expression in subjects with hyperthyroidism and hypothyroidism is partially relevant to a nonlinear regulation mechanism between visfatin and tri-iodothyronine with various concentrations显示文摘背景 Visfatin ,内脏的导出脂肪的 adipocytokine ,戏在类脂化合物 metabolism.However , visfatin 的精确功能和它由甲状腺荷尔蒙的规定的重要生理的功能仍然是观察的 unknown.This 学习在有在 vivo 的甲状腺机能亢进和甲状腺机能减退的题目的血浆 visfatin 集中,并且作为进一步的 interpretation.Methods 在 vitro 调查了在 visfatin 和 tri-iodothyronine ( T3 )之间的可能的规定机制在 vivo | HAN Jing ZHANG Tian-ou XIAO Wen-hua CHANG Cui-qing AI Hua | 2012 | Chinese Medical Journal2012，，5： | 11 |
| 6 | Effect of electroacupunture on gastric mucosal intestinal trefoil factor gene expression of stress-induced gastric mucosal injury in rats显示文摘瞄准:在 Foot-Yangming ( SMFY )的胃顶点的 acupoints 调查电镀物品针灸( EA ),胃的粘膜的肠的翘摇上的 Foot-Yangming ( SMFY )的胆囊顶点在有胃的粘膜的导致压力的老鼠的因素( ITF )基因表示察觉损害,并且探索EA相关的胃的粘膜的规章的机制和意义保护的效果。方法:四十只老鼠随机被划分成 4 个组:空白的组,为组建模,在 SMFY 组(“ SMFY 组”) 的 acupoints 为 group+EA 建模,并且为在 GMFY 组(GMFY 组) 的 acupoints 的 group+EA 建模。所有老鼠(除了空白的组) 走水路被成为模型沉浸和抑制应力(WRS ) 。然后,在每只老鼠的胃粘膜织物在对胃的粘膜损害索引(图形用户界面) 的评价以后被脱掉,并且纸巾的 ITF mRNA 的表示被反向的抄写聚合酶检测链反应(RT-PCR ) 方法。结果:与模型组相比(54.3+/- 1.34 ),在 SMFY 的图形用户界面价值组织(31+/- 2.21 )显著地减少了( P< 0.01 ),那么做了在 GMFY 组织(39.8+/- 1.62 , P< 0.05 ),同时,在 SMFY 的图形用户界面价值组织比在 GMFY 组( P< 0.01 )显著地低。与模型组相比(0.65+/- 0.01 ) , EA 有一个趋势改进胃的粘膜 ITFmRNA 的表示基因:如此的趋势在 GMFY 组存在(0.66+/- 0.01 ) 但是没有有效差量(P>0.05 ) ,在 SMFY 组(0.76+/- 0.01 ) 与极其明显的差别(P< 0.01 ) ,而且,在 SMFY 的表示组织比在 GMFY 组(P< 0.01 ) 显著地高。结论:由在 SMFY 和 GMFY 的 acupoints 的 EA 的胃的粘膜 protective 效果与 ITF 的表示变化有关,显示某些顶点特性存在。它能是为 TCM 理论的一个证明“在 SMFY 和胃之间的相对个性”。 | Xi-Ping Li Jie Yan Shou-Xiang Yi Xiao-Rong Chang Ya-Ping Lin Zong-Bao Yang Ai Huang Rong Hu | 2006 | World Journal of Gastroenterology2006，12，12： | 10 |
| 7 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 8 | Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine显示文摘The non-classical HLA class I antigen HLA-G is an immune modulator which inhibits the functions of T cells, NK cells, and the Dendritic cells (DC). As a result, HLA-G expression in malignant cells may provide them with a mechanism to escape the immune surveillance. In melanoma, HLA-G antigen expression has been found in 30% of surgically removed lesions but in less than 1% of established cell lines. One possible mechanism underlying the differential HLA-G expression in vivo and in vitro is that the HLA-G gene is epigenetically repressed in melanoma cells in vitro. To test this hypothesis, we treated the HLA-G negative melanoma cell line OCM-1A with the DNA methyltransferase inhibitor 5-aza-2’-deoXycytidine (5-AC) and analyzed whether HLA-G expression can be restored. Our data strongly suggest that HLA-G is silenced as a result of CpG hypermethylation within a 5’ regulatory region encompassing 220 bp upstream of the start codon. After treatment, HLA-G mRNA expression was dramatically increased. Western blot and flow cytometry showed that HLA-G protein was induced. Interestingly, HLA-G cell surface expression on the 5-AC treated OCM-1 A cells is much less than that on the HLA-G positive JEG-3 cells while a similar amount of total HLA-G was observed. Possible mechanisms for the difference were analyzed in the study such as cell cold-treatment, peptide loading and antigen processing machinery components (APM) as well as β2 microglobulin (β2-m) expression. Data revealed that the APM component calreticulin might be involved in the lower HLA-G surface expression on OCM-1 A cells. Taken together, our results indicated that DNA methylation is an important epigenetic mechanism by which HLA-G antigen expression is modulated in melanoma cells in vitro. Furthermore, to the first time, we hypothesized that the deficiency of calreticulin might be involved in the low HLA-G surface expression on the 5-AC treated OCM-1 A cells. | Wei Hua YAN Ai Fen LIN Chien Chung CHANG Soldano FERRONE | 2005 | Cell Research2005，15，7： | 5 |
| 9 | Synthesis,spectroscopic and electrochemical property of an unsymmetrical porphyrin and its Zn compound显示文摘在这篇文章,新 5-(p-maleicaminophenyl )-10,15,20-triphenylporphyrin (H2P ) 和相对的锌化合物(ZnP ) 借助于元素的分析,紫外鈥搗i s,红外, MS 和 1H NMR 光谱学被综合并且描绘。而且,我们调查了这些混合物的荧光光谱学。混合物的氧化和减小性质被周期的 voltammetry 学习,氧化鈥搑e duction 潜力被获得。 | Chang Fu Zhuang Yu Jing Zhang Ai Qing Xia Wen Hui Lian Yun Fang Wang Ping Zhang Tong Shun Shi | 2010 | Chinese Chemical Letters2010，21，7： | 3 |
| 10 | Activation of γ-aminobutyric Acid (A) Receptor Protects Hippocampus from Intense Exercise-induced Synapses Damage and Apoptosis in Rats显示文摘 | Yi Ding Lan Xie Cun-Qing Chang Zhi-Min Chen Hua Ai | 2015 | Chinese Medical Journal2015，，17： | 3 |
| 11 | Effects of the momentum dependence of nuclear symmetry potential on pion observables in Sn+Sn collisions at 270 MeV/nucleon显示文摘Within a transport model,we investigated the effects of the momentum dependence of the nuclear symmetry potential on the pion observables in central Sn+Sn collisions at 270 MeV/nucleon.To this end,the quantity U^(∞)_(sym)(ρ_(0))(i.e.,the value of the nuclear symmetry potential at the saturation densityρ_(0) and infinitely large nucleon momentum)was used to characterize the momentum dependence of the nuclear symmetry potential.With a certain L(i.e.,the slope of the nuclear symmetry energy at(ρ_(0))),the characteristic parameter U^(∞)_(sym)(ρ_(0))of the symmetry potential significantly affects the production of−and+and their pion ratios.Moreover,by comparing the charged pion yields,pion ratios,and spectral pion ratios of the theoretical simulations for the reactions ^(108) Sn+^(112) Sn and ^(132)Sn+^(124)Sn with the corresponding data in the SRIT experiments,we found that our results favor a constraint on U^(∞)_(sym)(ρ_(0))(i.e.,−160_(−9)^(+18) MeV),and L is also suggested within a range of 62.7 MeV | Gao‑Feng Wei Xin Huang Qi‑Jun Zhi Ai‑Jun Dong Chang‑Gen Peng Zheng‑Wen Long | 2022 | Nuclear Science and Techniques2022，33，12： | 3 |
| 12 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 13 | Efficacy of an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair in a rat model of polycystic ovary syndrome显示文摘OBJECTIVE:To identify active compounds in an Yinyanghuo(Herba Epimedii Brevicornus)-Xianmao(Rhizoma Curculiginis)drug pair(ECD)and investigate its efficacy on polycystic ovary syndrome(PCOS),and its possible mechanism in a rat model of PCOS.METHODS:A network pharmacology approach involving a characteristic drug assessment,active compound and target prediction,PCOS gene collection as well as network analysis was employed.The ovary morphology after treatment was observed using an animal model and western blotting and real-time PCR were used to verify AKT1 as the molecular target.RESULTS:Six networks were constructed,an active compound-target network for the ECD(C-T network),a drug-target network(D-T network),a related genes network,a targets interaction network,a key genes interaction network,and a gene-pathway network.A total of 41 compounds and 261 targets were identified for the ECD,232 PCOS-related genes,31 cogenes,and 14 pathways.These pathways may be involved in the efficacy of ECD on PCOS.The proteins most involved in the signal pathways for all targets were AKT1,IL6,INSR,ESR,and GSK3B.The AKT1 target was selected for experimental verification.Based on the Western blot and real-time PCR results,the expression of AKT1 in the PCOS model varied after treatment with ECD.CONCLUSIONS:Our findings suggest that the ECD can reverse the negative morphological changes in ovarian tissue that occur in model rats of PCOS.AKT1 may be a key mediator of the observed ability of the ECD to protect against PCOS in the model rats. | LIU Chang LIU Lihong LI Nan XIU Aihui ZHANG Zhixing AI Hao | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 2 |
| 14 | Endoscopic transaxfllary subfascial approach for persistent muscular torticollis in children 显示文摘 | Chang YT Lee JY Chiu WC et aI | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，2： | 1 |
| 15 | Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: results after 3 years of therapy显示文摘 | Leung NW Lai CL Chang IT et aI | 2001 | Hepatology2001，33，： | 1 |
| 16 | Angiographic morphologic features of infarct-related arteries and timely reperfusion in acute myocardial infarction:predictors of slow-flow and no-flow显示文摘 | Yip HK Chen MO Chang HW et aI | 2002 | Chest2002，122，4： | 1 |
| 17 | A multi-step induced strategy to fabricate core-shell Pt-Ni alloy as symmetric electrocatalysts for overall water splitting显示文摘Devising an electrocatalyst with brilliant efficiency and satisfactory durability for hydrogen production is of considerable demand,especially for large-scale application.Herein,we adopt a multi-step consequential induced strategy to construct a bifunctional electrocatalyst for the overall water splitting.Graphene oxide(GO)was used as a carbon matrix and in situ oxygen source,which was supported by the octahedral PtNi alloy to form the PtxNiy-GO precursor.When calcinating in Ar atmosphere,the oxygen in GO induced the surface segregation of Ni from the PtNi octahedron to form a core-shell structure of Ptx@Niy.Then,the surface-enriched Ni continuously induced the reformation of C in reduced graphene oxide(rGO)to enhance the degree of graphitization.This multi-step induction formed a nanocatalyst Pt_(x)@Ni_(y)-rGO which has very high catalytic efficiency and stability.By optimizing the feeding ratio of PtNi(Pt:Ni=1:2),the electrolytic overall water splitting at 10 mA·cm^(-2) can be driven by an electrolytic voltage of as low as 1.485 V,and hydrogen evolution reaction(HER)only needs an overpotential of 37 mV in 1.0 M KOH aqueous solution.Additionally,the catalyst exhibited consistent existence form in both HER and oxygen evolution reaction(OER),which was verified by switching the anode and cathode of the cell in the electrolysis of water.This work provides a new idea for the synthesis and evaluation of the bifunctional catalysts for water splitting. | Wenjuan Xu Jinfa Chang Yinggang Cheng Hongqi Liu Jifan Li Yongjian Ai Zenan Hu Xinyue Zhang Yiming Wang Qionglin Liang Yang Yang Hongbin Sun | 2022 | Nano Research2022，15，2： | 1 |
| 18 | Hemichorea-hemiballism: an explanation for MP- signal changes显示文摘 | Shah DE Ho PM Chang C et aI | 1998 | AJNE Am J Neuroradiol1998，19，86： | 1 |
| 19 | MiR-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state显示文摘 | Lin S L Chang D Chang L S et aI | 2008 | RNA2008，14，10： | 1 |
| 20 | Use of the antral follicle count to predict the outcome of as- sisted reproductive technologies 显示文摘 | Chang MY Chiang CH Hsieh TT et ai | 1998 | Fertil Steril1998，69，3： | 1 |
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