2篇
您的检索式：作者名="Chanchan Cheng"
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| 1 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 2 | Preparation of Modified Enteromorpha-Immobilized Microbial Agent and Research on Diesel Removal Performance显示文摘Offshore oil pollution has caused serious impacts on plants and aquatic organisms in the marine ecosystem.Bioremediation of oil pollution by immobilized bacteria has aroused wide attention due to the high degradation rate compared with free bacteria.The properties of the carrier for immobilization play an important role in the oil degradation efficiency.In our study,a marine oil degrading bacteria Sp8(Shewanella algae)was selected from sea water,and enteromorpha was used as carrier material for the immobilization of Sp8.In order to increase the hydrophobicity,sodium dodecylbenzene sulfonate(SDBS)was used as modifier to modify the surface of enteromorpha by the dipping method.Sodium alginate was used as the embedding carrier,and anhydrous calcium chloride was used as the cross-linking agent to prepare the SDBS-E immobilized microbial agent by the embedding method.Compared with the degradation rate achieved by free bacteria(78.87±8.29%),the diesel removal rate accomplished by SDBS-E immobilized microbial agent increased to 90.39±1.24%.The analysis of diesel removal mechanism showed that the diesel removal pathway mainly included surface adsorption,internal uptake,and biodegradation.The diesel removal efficiency relied on surface adsorption in the early stage,and then depended on biodegradation in the later stage.The removal of diesel by SDBS-E immobilized microbial agent conformed to the quasi-first-order degradation kinetic model.The results of software-MOE suggested that enteromorpha-immobilized microbial agent adsorbed diesel mainly through hydrogen bonds formed with diesel components.This study can provide a research basis and idea for the practical application of immobilization technology to remove petroleum from seawater in the future. | Yang Yuping Li Nana Duan Weichao An Chenye Xue Jianliang Jiang Qing Cheng Dongle Shen Chanchan | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，3： | 0 |
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