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| 1 | Lubiprostone used with polyethylene glycol in diabetic patients enhances colonoscopy preparation quality显示文摘AIM: To assess the additive effect of lubiprostone on the quality of colon preparation in diabetics given single-dosed polyethylene glycol electrolyte(PEG)for colonoscopy.METHODS:This was an investigator-initiated,singlecenter,single-blinded prospective trial comparing the efficacy of L+PEG to PEG alone on colon preparation quality in diabetics undergoing screening colonoscopy.The study was approved by our institution’s IRB.The PEG was given as a single-dose to address patientcompliance concerns voiced by our IRB with splitdosing.All patients received only clear liquids the day prior to colonoscopy.Experimental group(Grp L)received PEG+1 dose L 2 h prior to and 2 h after PEG completion.Control group(Grp C)received only PEG the evening prior to the colonoscopy.Patients were randomly assigned to one of the 2 groups.The endoscopist was blinded to which colon prep was given and all colonoscopies were complete.Upon colonoscopy completion,the endoscopist rated the colon prep-quality by a validated 5-point Likert scale(1-excellent to 5-inadequate).RESULTS:Sixty patients were enrolled in the study;30 Grp L and 30 Grp C.Overall,patients were excluded due to study non-completion in 12(41%)Grp L and 5(17%) Grp C,P=0.04.Average colon preparation score Grp L =2.47 and Grp C=3.00,P=0.09.Although this was not statistically significant,there was a trend towards improved colon prep in Grp L.Statistical significance may have been achieved if completion rates had been similar between both study groups.CONCLUSION:Use of 2-L capsules with PEG resulted in a trend towards improved colon prep over PEG alone in diabetic patients when given as a single-dose regimen. | Erika Grigg Moonkyung C Schubert Joshua Hall Fadi Rahhal Dimple Raina Subbaramiah Sridhar Sherman M Chamberlain | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，7： | 5 |
| 2 | 紫杉醇局部治疗抑制猪静脉桥新生内膜形成和增厚的实验研究显示文摘目的 :局部药物治疗是一个很好的防治静脉桥病变的策略。本研究用抗细胞增殖药物紫杉醇处理大隐静脉桥后植入猪的颈动脉 ,以观察紫杉醇的抗细胞增殖作用在抑制静脉桥内膜平滑肌细胞增殖、迁移导致内膜形成和增厚的效果。方法 :将 10头猪的 2 0只大隐静脉桥分为两组。治疗组 :将大隐静脉桥 10只置于含有 10 μmol/L浓度的紫杉醇溶液中 (先用该溶液灌洗 )浸泡 1h后植入猪的颈动脉 ,紫杉醇是溶解在 2 5 μl/L的无水酒精中 ,对照组 10只大隐静脉桥置于单纯的酒精中浸泡。 4周后取开放的静脉桥进行组织学分析。结果 :①治疗组静脉桥新生内膜面积 (1 5 9± 0 95 )mm2 ,对照组新生内膜面积高达 (2 43± 1 3 5 )mm2 ,治疗组显著低于对照组 ,两组比较有非常显著的差异 ,P <0 0 1;②治疗组内膜平滑肌细胞密度均值为 (3 681± 193 5 ) /mm2 ,对照组为 (4 60 7± 1993 ) /mm2 ,两组比较有显著性差异 ,P <0 0 5 ;中膜平滑肌细胞密度均值治疗组 (2 13 9± 73 4) /mm2 ,对照组(3 62 9± 3 2 0 7) /mm2 ,两组比较有显著性的差异 ,P <0 0 5。结论 :紫杉醇可显著抑制静脉桥内膜、中膜平滑肌细胞的增殖 ,抑制新生内膜的形成 ,证明紫杉醇可在防治静脉桥闭塞方面发挥独特作用。 | 吴隐雄 Martin H Chamberlain Thomas Johnson Jason L Johnson Andrew C Newby Gianni D Angelin Martin Oberhoff Karl K Karsch | 2003 | 中国循环杂志2003，18，6： | 2 |
| 3 | GFP tagged pollen to monitor pollen flow of transgenic plants显示文摘 | Hudson L C Chamberlain D Stewart Jr C N | 2001 | Molecular Ecology Notes2001，1，： | 1 |
| 4 | The effects of the addition of various enzyme mixtures on the fermentation of perennial ryegrass silage and on its nutritional value for milk production in dairy cows显示文摘 | Chamberlain D C Robertsons S | 1992 | Anim Feed Sci Technol1992，37，： | 1 |
| 5 | Mechanical links between erosion and metamorphism in Nanga Parbat, Pakistan Himalaya 显示文摘 | Koons P O Zeitler P K Chamberlain C P Craw D Meltzer A S | 2002 | American Journal of Science2002，302，： | 1 |
| 6 | Molecular diagnosis and analysis of Chikungunya virus 显示文摘 | Edwards C J Welch SR Chamberlain J | 2007 | J Clin Virol2007，39，4： | 1 |
| 7 | The in vitro metabolism of D, L-lactic acid by rumen microorganisms 显示文摘 | Newbold C J Williams A G Chamberlain D G | 1987 | Journal of the Science of Food and Agriculture1987，38，： | 1 |
| 8 | Heat-producing elements and the thermal and baric patterns of metamorphic belts显示文摘 | Chamberlain C P Sonder L J | 1990 | Science1990，250，： | 1 |
| 9 | New Roles for Cis-Jasmone as an Insect Semiochemical and in Plant Defense显示文摘 | BIRKETT M A CAMPBELL C A CHAMBERLAIN K | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 10 | The role of laparoscopic nephrectomy in pediatric xanthogranulomatous pyelonephritis: a case report显示文摘 | F Brown Chamberlain Jennifer C | 2013 | Case reports in urology2013，2013，59： | 1 |
| 11 | Automating the visual resource management and harvest design process显示文摘 | Chamberlain B C Meitner M J | | 0，，1： | 1 |
| 12 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 13 | A Software Defined HF Radio显示文摘 | CHAMBERLAIN M C | 2005 | Military Communications Conference2005，，04： | 1 |
| 14 | Effect of dietary supple- ments of sodium bicarbonate on the utilization of nitrogen in thr rumen of sheep receiving a silage-based diet显示文摘 | Newbold C J Thomas P C Chamberlain D G | 1988 | J Agric Sci Camb1988，110，： | 1 |
| 15 | 显示文摘 | P C Thonas | 1986 | Grass Forage Sci1986，41，： | 1 |
| 16 | New roles for cis-jasmone as an insect semiochemical and in plant defense显示文摘 | Birkett M A Campbell C A M Chamberlain K | 2000 | PNAS2000，97，16： | 1 |
| 17 | Effect of intra- venous supplements of L-methionine on milk yield and composition in cows given silage-cereal diets 显示文摘 | CHAMBERLAIN D G THOMAS P C | 1982 | Journal of Dairy Research1982，49，1： | 1 |
| 18 | Carbon Isotopes Reveal Soil Organic Matter Dynamics Following arid Land Shrub Expansion显示文摘 | Connin S L Virginia R A Chamberlain C P | 1997 | Oecologia1997，110，： | 1 |
| 19 | Centrifugal contactors for laboratory-scale solvent extraction tests 显示文摘 | Leonard R A Chamberlain D B Conner C | 1997 | Separation Science and Technology1997，32，14： | 1 |
| 20 | Recombinant capripoxvirus expressing the hemagglutinin protein gene of rinderpest virus: protection of cattle against rinderpest and lumpy skin disease viruses 显示文摘 | Romero C H Barrett T Chamberlain R W | 1994 | Virology1994，204，： | 1 |
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