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| 1 | Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study显示文摘A simple, sensitive, and specific liquid chromatography tandem mass spectrometry (LC-MS/ MS) method was developed for the quantification of desloratadine (DL) in human plasma using desloratadine-d5 (DLD5) as an internal standard (IS). Chromatographic separation was performed using an Xbridge C18 column (50 mm 4.6 mm, 5 mm) with an isocratic mobile phase composed of 10 mM ammonium formate: methanol (20:80, v/v), at a flow rate of 0.7 mL/min. DL and DLD5 were detected with proton adducts at m/z 311.2-259.2 and 316.2-264.3 in multiple reaction monitoring (MRM) positive modes, respectively. Liquid-liquid extraction (LLE) method was used to extract the drug and the IS. The method was validated over a linear concentration range of 5.0-5000.0 pg/mL with a correlation coefficient of (r2)Z0.9994. This method demonstrated intra- and inter-day precision within 0.7-2.0% and 0.7-2.7%, and an accuracy within 101.4-102.4%, and 99.5-104.8%. DL was found to be stable throughout the freeze-thaw cycles, bench-top, and postoperative stability studies. This method was successfully applied in the analysis of plasma samples following oral administration of DL (5 mg) in 35 healthy Indian male human volunteers under fasting conditions. | Venkata Suresh Ponnuru B.R. Challa Ramarao Nadendla | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 5 |
| 2 | Lung Cancer: MicroRNA and Target Database显示文摘MicroRNAs(miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage.Recently,it has been reported that miRNAs could possibly play a critical role in cellular processes like regulation of cell growth,differentiation,and apoptosis,emphasizing their role in tumorigenesis.Likewise,several miRNA's are involved in lung cancer tumorigenesis.The present review puts forth a database of human miRNA's involved in lung cancer along with their target genes.It also provides sequences of miRNA's and their chromosomal locations retrieved from different databases like microCosm(218 microRNAs),PhenomiR(293 microRNAs),and mir2Disease(90 microRNAs) and target gene information such as the pathways like cell cycle regulation,angiogenesis,apoptosis etc.Though miRNA's are still to be explored,they hold a promise as therapeutic targets and diagnostic markers of cancer. | Challa KIRAN Ponnala DEEPIKA | 2012 | 中国肺癌杂志2012，15，7： | 4 |
| 3 | HORTISIM:A model for greenhouse crops and greenhouse climate显示文摘 | Gijzen H Heuvelink E Challa H | 1998 | Acta Horticulturae1998，456，： | 1 |
| 4 | License plate localization based on a probabilistic model显示文摘 | Rami AI-Hmouz Subhash Challa | 2010 | Machine Vision and Applications2010，21，3： | 1 |
| 5 | Fungal rhinosinusitis: a clinicopathological study from South India显示文摘 | Challa S Uppin S G Hanumanthu S | 2010 | Eur Arch Otorhinolaryngol2010，267，17： | 1 |
| 6 | Towards user accepted optimal control of greenhouse climate显示文摘 | van Straten G Challa H Buwalda F | | 0，，： | 1 |
| 7 | License plate localization based on a probabilistic model 显示文摘 | Rami A1-Hmouz Subhash Challa | 2010 | Machine Vision and Applications2010，21，： | 1 |
| 8 | Apoptosis in leukoaraiosis lesions显示文摘 | Brown WR Moody DM Challa VR | 2002 | J Neurol Sci2002，，： | 1 |
| 9 | Rho-kinase inhibitors offer a new approach in the treatment of glaucoma显示文摘 | Challa P ArnoldJ J | 2014 | Expert Opin Investig Drugs2014，23，1： | 1 |
| 10 | Serum adiponectin levels,insulin resistance,and Iipid profile in children born small for gestational age and affected by the severity of growth retadation of birth显示文摘 | Evaqelidou EN Giapros VI Challa AS | 2007 | Eur J Endocrinol2007，156，2： | 1 |
| 11 | Amino acidbased fluorescent chiral ionic liquid for enantiomeric recognition显示文摘 | Bwambok D K Challa S K Lowry M | 2010 | Anal Chem2010，82，： | 1 |
| 12 | Meningiomas:MR andhistopathologic features显示文摘 | Elster AD Challa VR Gilbert TH | 1989 | Radiology1989，170，3： | 1 |
| 13 | A study of the application of particle filters to single target tracking problem 显示文摘 | MORELANDE M R CHALLA S GORDON N | 2003 | Signal and Data Processing of Small Target2003，，5204： | 1 |
| 14 | Relationship between flowcytometric features and clinical behavior of meningiomas显示文摘 | Crone KR Challa VR Kute TE | 1988 | Neurosurg1988，23，： | 1 |
| 15 | Cerebral microvascular alterations in aging, leukoaiaiosis, and Alzbeimer's disease显示文摘 | MOODY D M BROWN W R CHALLA V R | 1997 | Ann N Y Acad Sci1997，826，： | 1 |
| 16 | Brain microemboli during cardiac surgery or aortography显示文摘 | Moody DM Bell MA Challa VR | 2005 | Ann Neurol2005，28，6： | 1 |
| 17 | Cyclodextrins in drug delivery: An updated review 显示文摘 | CHALLA R AHUJA A ALl J | 2005 | AAPS Pharm Sci Tech2005，6，2： | 1 |
| 18 | Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunoeompetent individuals显示文摘 | Tandon A Challa S Shanmugam M | 2009 | Neurol India2009，57，1： | 1 |
| 19 | A ctivation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas显示文摘 | Sareddy GR Panigrahi M Challa S | 2009 | NeurochemInt2009，55，5： | 1 |
| 20 | Triple negative breast cancer - our experience and review 显示文摘 | Krishnamurthy S Poornima R Challa VR | 2012 | Indian J Surg Oncol2012，3，1： | 1 |
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