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| 1 | Gastroesophageal reflux disease: Important considerations for the older patients显示文摘Gastroesophageal reflux disease (GERD) is the most common upper gastrointestinal disorder seen in the elderly. The worldwide incidence of GERD is increasing as the incidence of Helicobacter pylori is decreasing. Although elderly patients with GERD have fewer symptoms, their disease is more often severe. They have more esophageal and extraesophageal complications that may be potentially life threatening. Esophageal complications include erosive esophagitis, esophageal stricture, Barrett's esophagus and adenocarcinoma of the esophagus. Extraesophageal complications include atypical chest pain that can simulate angina pectoris; ear, nose, and throat manifestations such as globus sensation, laryngitis, and dental problems; pulmonary problems such as chronic cough, asthma, and pulmonary aspiration. A more aggressive approach may be warranted in the elderly patient, because of the higher incidence of severe complications. Although the evaluation and management of GERD are generally the same in elderly patients as for all adults, there are specific issues of causation, evaluation and treatment that must be considered when dealing with the elderly. | Maxwell M Chait | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 22 |
| 2 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 3 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 3 |
| 4 | Lower gastrointestinal bleeding in the elderly显示文摘Lower gastrointestinal bleeding(LGIB) is an important worldwide cause of morbidity and mortality in the elderly.The incidence of LGIB increases with age and corresponds to the increased incidence of specific gastrointestinal diseases that have worldwide regional variation,co-morbid diseases and polypharmacy.The evaluation and treatment of patients is adjusted to the rate and severity of hemorrhage and the clinical status of the patient and may be complicated by the presence of visual,auditory and cognitive impairment due to age and co-morbid disease.Bleeding may be chronic and mild or severe and life threatening,requiring endoscopic,radiologic or surgical intervention.Colonoscopy provides the best method for evaluation and treatment of patients with LGIB.There will be a successful outcome of LGIB in the majority of elderly patients with appropriate evaluation and management. | Maxwell M Chait | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 3 |
| 5 | Simvastatin and niacin,antioxidant vitamins,or the combination for the prevention of coronary disease显示文摘 | Brown BG Zhao XQ Chait A | | the New England Journal of Medicine0，，： | 2 |
| 6 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 2 |
| 7 | 2型糖尿病心血管疾病风险的机制研究显示文摘2型糖尿病患者的心血管疾病风险较未罹患者高。随着全球糖尿病发病率的上升,除了对血压和LDL-胆固醇的控制外,对残余风险的处理仍然十分重要。加速出现的动脉粥样硬化和心血管疾病可能与多种因素有关,因此,在治疗上应采取多种不同的疗法。体外(动物)和体内(人)相关机制的研究结果为改善临床处治和结局提供了潜在的、重要的理论支持。本综述主要就在加速的血管损伤中,以下三方面——高血糖、糖尿病脂质代谢紊乱(除控制LDL-胆固醇浓度外)及炎症(包括脂肪组织中)——的作用进行了阐述,其中包含有重要的病理生理学信息。 | Theodore Mazzone Alan Chait Jorge Plutzky 由凤秋(译) | 2008 | 世界临床医学2008，2，5： | 2 |
| 8 | Endoscopic management of tracheal and e-sophageal strictures显示文摘 | Forte V Chait P Sommer D | 2003 | Semin Pediatr Surg2003，12，： | 1 |
| 9 | Throughput differentiation using coloring at the network edge and preferential marking at the core 显示文摘 | Chait Y Hollot C V Misra V | 2005 | IEEE/ACM Transaction on Networking2005，13，4： | 1 |
| 10 | Neovascular expression of E - selectin, ICAM - 1 and VCAM - 1 in human atherosclerosis and their relation to intimal leukocyte content 显示文摘 | O'Brien KD McDonald To Chait A | 1996 | Circulation1996，93，4： | 1 |
| 11 | Chylomicronemia Syndrome显示文摘 | Chait A Brunzell JD | 1992 | Adv Intern Med1992，37，： | 1 |
| 12 | Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome显示文摘 | Oda Y Nagasu T Chait B T | 2001 | Nat Biotechnol2001，19，4： | 1 |
| 13 | Serum amyloid A:The other inflammatory protein显示文摘 | O'Brien KD Chait A | 2006 | Curr Atheroscler Rep2006，8，1： | 1 |
| 14 | The p17 cleaved form of caspase-3 is present within viable macrophages in vitro and in atherosclerotic plaque显示文摘 | Nhan T Q Liles W C Chait A | 2003 | Arterioscler Thromb Vasc Biol2003，23，7： | 1 |
| 15 | Serum amyloid A:the 'other'inflammatory protein显示文摘 | O'Brien KD Chait A | 2006 | Curr Atheroscler Rep2006，8，1： | 1 |
| 16 | A natural modal expansion for the flexible robot arm problem via a self-adjoint formulation显示文摘 | Chait Y Mik(l)avc(I)c M Maccluer C R | 1990 | IEEE Transaction on Robotics and Automation1990，6，5： | 1 |
| 17 | Prevention Conference Ⅵ: Diabetes and Cardiovascular Disease: Writing Group Ⅱ:pathogenesis of atherosclerosis in diabetes显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
| 18 | No tolerance to the antinoeiceptive action of calcitonin in rats and mice 显示文摘 | Aboufatima R Chait A Dalai A | 2004 | Neurosci Lett2004，359，： | 1 |
| 19 | Simvastatin and niacin,antioxidant vitamins,or the combination for the prevention of coronary disease显示文摘 | Brown BG Zhao XQ Chait A | 2001 | N Engl J Med2001，345，22： | 1 |
| 20 | Prevention conference Ⅵ: diabetes and cardiovascular disease writing group Ⅱ : pathogenesis of atherosclerosis in diabetes 显示文摘 | Eckel RH Wassef M Chait A | 2002 | Circulation2002，105，18： | 1 |
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