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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Red pigment production by Penicillium purpurogenum GH2 is influenced by pH and temperature显示文摘The combined effects of pH and temperature on red pigment production and fungal morphology were evaluated in a submerged culture of Penicillium purpurogenum GH2, using Czapek-Dox media with D-xylose as a carbon source. An experimental design with a factorial fix was used: three pH values (5, 7, and 9) and two temperature levels (24 and 34 °C) were evaluated. The highest production of red pigment (2.46 g/L) was reached with a pH value of 5 and a temperature of 24 °C. Biomass and red pigment production were not directly associated. This study demon- strates that P. purpurogenum GH2 produces a pigment of potential interest to the food industry. It also shows the feasibility of producing and obtaining natural water-soluble pigments for potential use in food industries. A strong combined effect (p<0.05) of pH and temperature was associated with maximal red pigment production (2.46 g/L). | Alejandro MéNDEZ Catalina PéREZ Julio Cesar MONTAéZ Gabriela MARTíNEZ Cristóbal Noé AGUILAR | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，12： | 4 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Enzymatic hydrolysis of lime-pretreated corn stover and investigation of the HCH-1 model: inhibition pattern, degree of inhibition,validity of simplified HCH-1 model 显示文摘 | Jonathan P Zhu L Cesar B G | 2007 | Bioresource Technology2007，98，16： | 1 |
| 5 | Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3receptors显示文摘 | Souslova V Cesare P Ding Y | 2000 | Nature2000，407，6807： | 1 |
| 6 | Genetic Structure of an Endangered Plant,Antirrhinum microphyllum (Scrophulariaceae):Allozyme and RAPD Analysis显示文摘 | Elena T Jose M I Cesar P | 2003 | American Journal of Botany2003，90，： | 1 |
| 7 | A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone selected colon carcinoma cell line 显示文摘 | Perego P De Cesare M De Isabella P | 2001 | Cancer Res2001，61，16： | 1 |
| 8 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 9 | Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training显示文摘 | Cesar T B Aptekmann N P | | 0，，04： | 1 |
| 10 | Biochemical properties and barley yield in a semia rid Mediterr anean soil a-mended with two kinds of sewage sludge显示文摘 | Fernandez J M Cesar P Juan C | 2009 | Appied Soil Ecology2009，，42： | 1 |
| 11 | Variable epitope library-based vaccines:shooting moving targets显示文摘 | CESAR P R CLAUDIA C N RAFAEL S | 2009 | Molecular Immunology2009，47，2： | 1 |
| 12 | Degradation of sodium an thraquin-one sulphonate by free and immobilized bacterial cultures显示文摘 | Meriem B Nevenka A Cesar P | 1994 | Appl Microbiol Biotechnol1994，41，1： | 1 |
| 13 | Ion channels gated by heat 显示文摘 | Cesare P Moriondo A Vellani V | 1999 | Proceedings of the National Academy of Sciences of the United States of America1999，96，14： | 1 |
| 14 | The recreational value of coral reefs : A meta-analysis显示文摘 | Brander L M Beukering P V Cesar H SJ | 2007 | Ecological Economics2007，63，1： | 1 |
| 15 | Sources of cardiomyocytes for stem cell therapy:an update显示文摘 | Pasquale G Cesare P Gianluigi C | 2006 | Pediatric Res2006，59，4： | 1 |
| 16 | Chloroplast isolation from Laminaria digitata:A reproducible methodology yielding photosynthetically active chloroplasts显示文摘 | STRBAC D MARCOAURELIO A R CESAR P | 1994 | Planta1994，195，： | 1 |
| 17 | A biomechanical comparison of 2 femoral fixation techniques for anterior erueiate ligament reconstruction in skeletally immature patients: over-the- top fixation versus transphyseal technique显示文摘 | Lertwanieh P Cesar YK Martins AQ | 2011 | Arthroseopy2011，27，： | 1 |
| 18 | Antiproliferative effect and apoptotic response in vitro of human melanoma cells to liposomes containing the ribosome-inactivating protein luffin显示文摘 | Poma A Marcozzi G Cesare P | 1999 | Biochim Biophys Acta1999，1472，12： | 1 |
| 19 | Role of apoptosis and apoptosis-related genes in cellular response and antitumor efficacy of anthracyclines显示文摘 | Perego P Coma E De Cesare MD | 2001 | Curr Med Chem2001，8，1： | 1 |
| 20 | CREM, a master switch of the transcriptional cascade in male germ cells显示文摘 | De Cesare D Fimia GM SassoneCorsi P | 2000 | J Endocrinol Invest2000，23，9： | 1 |
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