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| 1 | Modified constraint-induced movement therapy alters synaptic plasticity of rat contralateral hippocampus following middle cerebral artery occlusion显示文摘Modified constraint-induced movement therapy is an effective treatment for neurological and motor impairments in patients with stroke by increasing the use of their affected limb and limiting the contralateral limb.However,the molecular mechanism underlying its efficacy remains unclear.In this study,a middle cerebral artery occlusion(MCAO)rat model was produced by the suture method.Rats received modified constraint-induced movement therapy 1 hour a day for 14 consecutive days,starting from the 7^th day after middle cerebral artery occlusion.Day 1 of treatment lasted for 10 minutes at 2r/min,day 2 for 20 minutes at 2 r/min,and from day 3 onward for 20 minutes at 4 r/min.CatWalk gait analysis,adhesive removal test,and Y-maze test were used to investigate motor function,sensory function as well as cognitive function in rodent animals from the 1st day before MCAO to the 21^st day after MCAO.On the 21^st day after MCAO,the neurotransmitter receptor-related genes from both contralateral and ipsilateral hippocampi were tested by micro-array and then verified by western blot assay.The glutamate related receptor was shown by transmission electron microscopy and the glutamate content was determined by high-performance liquid chromatography.The results of behavior tests showed that modified constraint-induced movement therapy promoted motor and sensory functional recovery in the middle cerebral artery-occluded rats,but had no effect on cognitive function.The modified constraint-induced movement therapy upregulated the expression of glutamate ionotropic receptor AMPA type subunit 3(Gria3)in the hippocampus and downregulated the expression of the beta3-adrenergic receptor gene Adrb3 and arginine vasopressin receptor 1 A,Avprla in the middle cerebral artery-occluded rats.In the ipsilateral hippocampus,only Adra2 a was downregulated,and there was no significant change in Gria3.Transmission electron microscopy revealed a denser distribution the more distribution of postsynaptic glutamate receptor 2/3,which is an a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor,within 240 nm of the postsynaptic density in the contralateral cornu ammonis 3 region.The size and distribution of the synaptic vesicles within 100 nm of the presynaptic active zone were unchanged.Western blot analysis showed that modified constraint-induced movement therapy also increased the expression of glutamate receptor 2/3 and brain-derived neurotrophic factor in the hippocampus of rats with middle cerebral artery occlusion,but had no effect on Synapsin I levels.Besides,we also found modified constraint-induced movement therapy effectively reduced glutamate content in the contralateral hippocampus.This study demonstrated that modified constraint-induced movement therapy is an effective rehabilitation therapy in middle cerebral artery-occluded rats,and suggests that these positive effects occur via the upregulation of the postsynaptic membrane a-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor expression.This study was approved by the Institutional Animal Care and Use Committee of Fudan University,China(approval No.201802173 S)on March 3,2018. | Bei-Yao Gao Dong-Sheng Xu Pei-Le Liu Ce Li Liang Du Yan Hua Jian Hu Jia-Yun Hou Yu-Long Bai | 2020 | Neural Regeneration Research2020，15，6： | 19 |
| 2 | Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling显示文摘Bone remodeling is precisely coordinated by bone resorption and formation.Apoptotic osteoclasts generate large amounts of apoptotic bodies(ABs)marking the end of the bone resorption phase,whereas the functions of osteoclast-derived ABs remain largely unknown.Here,we identified the molecular profile of ABs derived from osteoclasts at distinct differentiation stages and investigated their corresponding functions.ABs were isolated from apoptotic bone marrow macrophages,preosteoclasts,and mature osteoclasts induced by staurosporine.Proteomic signature analysis with liquid chromatography-tandem mass spectrometry suggested marked protein cargo differences among the different ABs.Further bioinformatic analysis showed that the proteomic signatures of the ABs were highly similar to those of their parental cells.Functionally,pOC-ABs induced endothelial progenitor cell differentiation and increased CD31hiEmcnhi endothelial cell formation in a murine bone defect model via their PDGF-BB cargo.mOC-ABs induced osteogenic differentiation of mesenchymal stem cells and facilitated osteogenesis via RANKL reverse signaling.In summary,we mapped the detailed proteomic landscapes of ABs derived from osteoclasts and showed that their potential biological roles are important in coupling bone formation with resorption during bone remodeling. | Qinyu Ma Mengmeng Liang Yutong Wu Fei Luo Zaisong Ma Shiwu Dong Jianzhong Xu Ce Dou | 2021 | Bone Research2021，9，1： | 8 |
| 3 | Size,morphology,and composition of lunar samples returned by Chang'E-5 mission显示文摘This study focuses on the physical and chemical properties of surficial lunar regolith(LR)samples returned from the Moon by the Chang’E-5(CE-5)mission.Insights regarding the effect of a new sampling geological site on the surficial lunar sample CE5 C0400 were illustrated using nondestructive techniques such as laser diffractometry coupled with image analysis,X-ray computed tomography,and field emission scanning electron microscopy equipped with energy dispersive spectroscopy,and Xray diffraction combined with Rietveld refinement.From the characterization analyses,the CE-5 sampling site in the northeastern Oceanus Procellarum on the Moon yields a unique collection of relatively regular-shaped and fine basalt-dominated particles.The median grain size D_(50) is(55.24±0.96)μm,falling within the relatively low end of the range of the Apollo lunar returned samples.The coefficient of uniformity C_(u)of 15.1 and the coefficient of curvature C_(c)of 1.7 could classify CE5 C0400 to be well-graded.The minerals in CE5 C0400 comprise approximately 44.5%pyroxene,30.4%plagioclase,3.6%olivine,and6.0%ilmenite.There is a relatively low content of approximately 15.5%glass phase in the CE-5 lunar sample.From the results,we deduce that the CE-5 LR structure could have mainly resulted from micrometeoroid impacts to achieve such a high level of maturity. | Hui Zhang Xian Zhang Guang Zhang Keqi Dong Xiangjin Deng Xiaosong Gao Yaodong Yang Yuan Xiao Xiao Bai Kaixin Liang Yiwei Liu Wenbin Ma Shaofan Zhao Ce Zhang Xiaojing Zhang Jian Song Wei Yao Hong Chen Weihua Wang Zhigang Zou Mengfei Yang | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，2： | 4 |
| 4 | A quantitative morphometric comparison of cockpit and doline karst landforms显示文摘这研究由检验在桂林被开发的地形实体的典型类型的数字和特征介绍了座舱和斗淋石灰岩地区常见的地形的量的比较( Guangxi ,中国), La Alianza ( PR ,美国), Avalton ( KY ,美国),并且鲕状(在里面,美国)。地形实体的五种类型被定义:孤立的山(IH ) ,聚类的山(CH ) ,孤立的阴沟的入口处() ,聚类的阴沟的入口处(CS ) ,和有阴沟的入口处(CHS ) 的聚类的山。一个算法被开发自动地由在二个座舱石灰岩地区常见的地形区域(桂林和 La Alianza ) 和二个斗淋石灰岩地区常见的地形区域的地志的地图上检验轮廓线识别地形实体的这些类型(鲕状并且 Avalton ) 。在每个特定的学习区域以内, CHS 还与一种更大的尺寸和更高的地势是最少的发达类型。IH 并且实体在尺寸是更小的,在地势降低,并且在数量上超过他们的聚类的对应物。实体的这些类型的全部的数字在座舱和斗淋石灰岩地区常见的地形区域是相当不同的。斗淋石灰岩地区常见的地形被更多描绘否定(并且 CS ) 比积极(IH 和 IH ) 地形并且反过来也如此为座舱石灰岩地区常见的地形。例如,桂林学习区域总共有 1192 个积极地形实体,它占据 9.81% 全部的学习区域。它有 622 个仅仅否定地形实体仅仅占据 3.91% 全部的学习区域。由对比,斗淋石灰岩地区常见的地形在鲕状有 130 否定当时 10 个仅仅积极地形实体。积极、否定的地形在鲕状分别地占据 12.68% 全部的学习区域和 2.61% 。而且,地形实体的平均地势和斜坡在座舱石灰岩地区常见的地形高得多比斗淋石灰岩地区常见的地形区域、更陡峭。例如,当它是在 La Alianza 的 19.78 度时,在 Alvaton 的 CH 的平均斜坡是 3.90 度。CS 的平均消除是 4.07 m 和 34.29 m 在鲕状并且桂林分别地。在一个特定的区域以内或在座舱和斗淋石灰岩地区常见的地形之间的如此的差别可以在石灰岩地区常见的地形风景的开发揭示不同控制。 | LIANG Fuyuan DU Yunyan GE Yong LI Ce | 2014 | Journal of Geographical Sciences2014，24，6： | 4 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | Redefinition and Formation Age of the Tanjianshan Group in Xitieshan Region, Qinghai显示文摘The Tanjianshan Group, which was previously divided into a, b, c and d formations, has been controversial for a long time. It mainly distributes in the northern margin of Qaidam Basin and is an important early Paleozoic greenschist facies metamorphic volcanic sedimentary rock formation. Detailed field investigation and zircon LA-ICPMS U-Pb dating of the key strata suggest that the original lower part of a Formation(a-1) versus the original middle upper of d Formation(d-3 and d-4), the original upper part of a Formation(a-2) and b Formation versus the original lower part of d Formation(d-1 and d-2) of Tanjianshan Group are contemporaneous heterotopic facies volcanicclasolite deposit, respectively. The former formations formed during the middle-late Ordovician(463–458 Ma), while the latter ones formed in the late Ordovician(about 445 Ma). The original c formation of Tanjianshan Group, which formed after 430 Ma, is similar to the Maoniushan Formation of Kunlun Mountains and north Qaidam Basin. According to the rules of stratigraphic division and naming, new stratum formations of Tanjianshan Group are re-built and divided into Duancenggou(O1-2td), Zhongjiangou(O2-3tz) and Xitieshan(O3tx) formations. The original c Formation is separated from Tanjianshan Group and is renamed as the Wuminggou Formation(S3-D1w), which shows a discordant contact with underlying Tanjianshan Group and overlying Amunike Formation(D3a). The zircon U-Pb age frequency spectrogram of Tanjianshan Group indicates three prominent peaks of 430 Ma, 460 Ma and 908 Ma, which is consistent with the metamorphic and magmatic crystallization ages obtained from para- and orthogneisses in north Qaidam HP-UHP metamorphic belt, implying that strong Caledonian and Jinningian tectonic and magmatic events have ever happened in North Qaidam. | LIANG Xinquan FU Jiangang WANG Ce JIANG Ying ZHOU Yun YANG Yongqiang WANG Zeli PAN Chuanchu | 2014 | Acta Geologica Sinica(English Edition)2014，88，2： | 3 |
| 7 | Multiple active components synergistically driven heteroatom-doped porous carbon as high-performance counter electrode in dye-sensitized solar cells显示文摘A facile template-free in situ self-activation approach for the multiple active components synergistically driven porous carbon was presented via a feasible annealing process.The biomass-derived carbon without additional activation reagents was fabricated using K-rich pomelo peel(PP)as the carbon source,which possesses a high electric conductivity where abundant functional hetero-metal atoms are doped into the carbon framework that playing the role of catalytic graphitization.The K^+that exists within the biomass can induce self-activation during pyrolysis apart from the activating gases during the pyrolysis process.The resulting electrocatalyst of PP-850(PP was pyrolyzed at 850°C in an N_2atmosphere)with abundant heteroatoms possesses a higher power conversion efficiency(PCE)of 7.81%as the counter electrode(CE)of dye-sensitized solar cells(DSCs)compared with the CEs calcinated at other temperatures and a similar PCE with Pt counterpart(8.24%)based on the liquid I_3^-/I^-electrolyte.The better electrocatalytic performance is attributed to the synergistic effect between self-activation and the co-doping of nitrogen,sulfur and phosphorus all together in a carbon matrix.Due to the feasibility of large-scale production,rich heteroatom doping,the PP-derived carbon,which simplifies the procedure and decreases the cost,has a potential application for an alternative electrocatalyst for high-performance photovoltaic devices. | Hongyu Jing Danyang Wu Suxia Liang Xuedan Song Yonglin An Ce Hao Yantao Shi | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 8 | Detrital Zircon U-Pb Geochronology: New Insight into the Provenance of Sanya Formation in the Yinggehai Basin显示文摘Objective The NNW-SSE trending Yinggehai Basin,located on the continental shelf at water depths of 50-200 m in the northwestern South China Sea,is a Cenozoic conversion extensional basin.Over the past decades,a number of hydrocarbon reservoirs have been discovered in the deepwater area of the basin,including the Lingtou Formation(Eocene),Yacheng and Lingshui | WANG Ce LIANG Xinquan FU Jiangang JIANG Ying DONG Chaoge | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 2 |
| 9 | Detrital Zircon Provenance of Pliocene Yinggehai Formation in the Ledong Gas Field of the Yinggehai-Song Hong Basin显示文摘1 Introduction Over the past decades,a number of hydrocarbon reservoirs have been discovered in the deepwater area of the Yinggehai-Song Hong Basin,South China Sea.The NW-oriented Yinggehai-Song Hong Basin,located on the continental shelf at water depths of 50-200 m in the northwestern South China Sea,is one of the | WANG Ce LIANG Xinquan FU Jiangang ZHOU Yun JIANG Ying DONG Chaoge | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 10 | Comparison of recovery and deliveryin vitrofor calibration of microdialysis probes显示文摘 | Zhao YP Liang XZ Lunte CE | 1995 | Anal Chim Acta1995，316，3： | 1 |
| 11 | Comprehensive e- valuation of differential gene expression analysis methods for RNA-seq data显示文摘 | Rapaport F Khanin R Liang Y Pirun M Krek A Zum-bo P Mason CE Socci ND Betel D | 2013 | Genorne Biol2013，14，： | 1 |
| 12 | The antieancer agent YC-1 suppresses progestin-stimulated VEGF in breast cancer cells and arrests breast tumor development 显示文摘 | Carroll CE Liang Y Benakanakere I | 2013 | Int J Oncol2013，42，1： | 1 |
| 13 | DNA methylation differences associ- ated with tumor tissues identified by genome scanning analysis 显示文摘 | Liang G Salem CE Yu MC | 1998 | Genomics1998，53，3： | 1 |
| 14 | Bone morphogenetic protein-1/ tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis显示文摘 | Ce C Seo NS Liang X | 2004 | J Biol Chem2004，279，41： | 1 |
| 15 | Scattering of seismic waves by three-dimensional large-scale hill topography simulated by a fast parallel IBEM显示文摘To solve seismic wave scattering by a large-scale three-dimensional(3-D) hill topography, a fast parallel indirect boundary element method(IBEM) is developed by proposing a new construction method for the wave field, modifying the generalized minimum residual(GMRES) algorithm and constructing an Open MP plus MPI parallel model. The validations of accuracy and efficiency show that this method can solve 3-D seismic response of a large-scale hill topography for broadband waves, and overcome the weakness of large storage and low efficiency of the traditional IBEM. Based on this new algorithm architecture, taking the broadband scattering of plane SV waves by a large-scale Gaussian-shaped hill of thousands-meters height as an example, the influence of several important parameters is investigated, including the incident frequency, the incident angle and the height-width and length-width ratio of the hill. The numerical results illustrate that the amplification effect on the ground motion by a near-hemispherical hill is more significant than the narrow hill. For low-frequency waves, the scattering effect of the higher hill is more pronounced, and there is only a single peak near the top of the hill. However, for high-frequency waves, rapid spatial variation of displacement amplitude appears on the hill surface. | Liu Zhongxian Shang Ce Huang Lei Liang Jianwen Li Jie | 2020 | Earthquake Engineering and Engineering Vibration2020，19，4： | 1 |
| 16 | Physiologically Based Pharmacokinetic Modeling for 1-Bromopropane in F344 Rats Using Gas Uptake Inhalation Experiments显示文摘 | Garner CE Liang S Yin L | 2015 | Toxicol Sci2015，145，1： | 1 |
| 17 | Binding of a 4-methyl-4-aza-steroid to 5 alpha-reductase of rat liver and prostate microsomes显示文摘 | Liang T Heiss CE Ostrove S Rasmusson GH Cheung A | 1983 | Endocrinology1983，112，4： | 1 |
| 18 | Physiologically based pharmacokinetic modeling for 1-bromopropane in f344 rats using gas uptake inhalation experiments显示文摘 | Garner CE Liang S Yin L | 2015 | Toxicol Sci2015，45，1： | 1 |
| 19 | Application of biological activated carbon as a low pH biofilter medium for gas mixture treatment显示文摘 | Juan Liang Lawren ce Koe Choon Chiaw | 2007 | Biotechmology Bioengineering2007，96，6： | 1 |
| 20 | Real-time Texture Synthesis by Patch-based Sampling显示文摘 | Liang Lin Liu Ce Xu Yingqing | 2001 | ACM Transactions on Graphics2001，20，3： | 1 |
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