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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Biomarker discovery in neurodegenerative diseasess:a proteomic approach显示文摘 | Shi M Caudle WM Zhang J | 2009 | Neurobiol Dis2009，35，2： | 1 |
| 3 | To Tag or not to tag? 显示文摘 | Thomas M Caudle D M Schmitz Cecilia M | 2009 | Library Hi Tech2009，3，： | 1 |
| 4 | Modeling of a micellar/polymer process 显示文摘 | Bang H W Caudle B H | 1984 | SPEJ1984，，12： | 1 |
| 5 | Exerise induces be havioral recovery and attenuates neurohemical deficits in rodent models of Parkinson' s disease显示文摘 | Tillerson JL Caudle WM Reveron ME | 2003 | Neunoscience2003，119，4： | 1 |
| 6 | To tag or not to tag显示文摘 | Thomas M Caudle D M Schmitz C M | 2009 | Library HiTech2009，27，3： | 1 |
| 7 | Improving miscible displacement by gas-water injection 显示文摘 | Caudle B H Dyes A B | 1959 | Transactions of AIME1959，213，： | 1 |
| 8 | Metastasectomy for stage IV melanoma:forwhom and how much 显示文摘 | Caudle AS Ross MI | 2011 | - Surg Oncol Clin N Am2011，20，1： | 1 |
| 9 | Origin of germ cells and formation of new primary follicles in adult human ovaries显示文摘 | Bukovsky A Caudle Svetlikova M | 2004 | Re- prod Biol Endocrinol2004，2，： | 1 |
| 10 | Model studies of the inverted nine-spot injection pattern 显示文摘 | Watson R E Silberberg L H Caudle B H | 1964 | Journal of Petroleum Technology1964，16，7： | 1 |
| 11 | Melorheostosis of the hand: a case report with long-term follow up显示文摘 | Caudle RJ Stern PJ | 1987 | J Bone Joint Surg1987，69，8： | 1 |
| 12 | Severe open fractures of the tibia显示文摘 | Caudle BJ Stern PJ | 1987 | J Bone Joint Surg(Am)1987，69，： | 1 |
| 13 | Abnormal expression of p27 kipl protein in levator animuscle of aging women with pelvic floor disorders-a relationship to the cellular differentiation and degeneration显示文摘 | Bukovsky A Copas P Caudle MR | 2001 | BMC Clin Pathol2001，1，1： | 1 |
| 14 | Local-regional control according to surrogate markers of breast cancer subtypes and response to neoad-juvant chemotherapy in breast cancer patients undergoing breast con-serving therapy 显示文摘 | Caudle AS Yu TK Tucker SL | 2012 | Breast Cancer Res2012，14，3： | 1 |
| 15 | Fourth generation fluoroquinolone penetration into the aqueous humor in humans 显示文摘 | Mc Culley JP Caudle D Aronowicz JD | 2006 | Ophthalmology2006，113，： | 1 |
| 16 | Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitro显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2008 | Cell Cycle2008，7，22： | 1 |
| 17 | Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)显示文摘 | Richardson J R Caudle W M Guillot T S Watson J L Nakamaru-Ogiso E Seo B B Sherer T B Greenamyre J T Yagi T Matsuno-Yagi A Miller G W | | 0，，01： | 1 |
| 18 | The neoadjuvant approach in breast cancer treatment it is not just about chemotherapy anymore显示文摘 | Caudle AS Hant KK | 2011 | Current opinion in obstetrics & gynecology2011，，23： | 1 |
| 19 | Olfactory discrimination deficits in mice lacking the dopamine transporter or the D2 dopa-mine receptor显示文摘 | Tillerson JL Caudle WM Parent JM | 2006 | Behav Brain Res2006，172，1： | 1 |
| 20 | Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkmson s dlsease显示文摘 | Tillerson JL Caudle WM Reveron ME | 2003 | Neuroscience2003，119，： | 1 |
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