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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | Risk factors for isolated biliary atresia, National Birth Defects Prevention Study, 1997-2002显示文摘 | THE N S HONEIN M A CATON A R | 2007 | Am J Med Genet A2007，143，19： | 1 |
| 3 | Notch2 receptor signal- ing controls functional differentiation of dendritic cells in the spleen and intestine 显示文摘 | Lewis KL Caton ML Bogunovic M | 2011 | Immunity2011，35，5： | 1 |
| 4 | Nicotinamide mononueleotide protects against pro- inflammatory cytokine-mediated impairment of mouse islet function 显示文摘 | CATON P W KIESWICH J YAQOOB M M | 2011 | Diabetologia2011，54，12： | 1 |
| 5 | The digestive strategy of the common marmoset, Callithrix jacchus显示文摘 | Caton J M Hill D M Hume I D | 1996 | Comp Biochem Physiol1996，4，1： | 1 |
| 6 | NotchRBPJ signalingcontrols the homeostasis of CD8dendritic cells in the spleen显示文摘 | Caton M Smith-Raska M Reizis B | 2007 | The Journal of Experimental Medicine2007，204，7： | 1 |
| 7 | Stability of Shot Peen Residual Stresses in IN100 Subjected to Creep and Fatigue Loading显示文摘 | John R Buchanan D J Caton M J | 2010 | Procedia Engi- neering2010，2，1： | 1 |
| 8 | Effects of plane of nutrition and selenium supply during gestation on ewe and neonatal offspring performance, body composition, and serum selenium显示文摘 | Meyer A M Reed J J Neville T L Taylor J B Hammer C J Reynolds L P Redmer D A Vonnahme K A Caton J S | 2010 | Journal of Animal Science2010，88，5： | 1 |
| 9 | The effect of solidification rate on the growth of small fatigue cracks in a cast 319 type aluminum alloy显示文摘 | Caton M J | 1999 | Met Mater Trans A1999，30，： | 1 |
| 10 | Periodontal regeneration via selective cell repopulation显示文摘 | Caton J G DeFuria E L Polson A M | 1987 | Journal of Periodontology1987，58，8： | 1 |
| 11 | Effects of selenium supply and dietary restriction on maternal and fetal body weight, visceral organ mass and cellularity estimates, and jejunal vascularity in pregnant ewe lambs显示文摘 | Reed J J Ward M A Vonnahme K A Neville T L Julius S L Borowicz P P Taylor J B Redmer D A Grazul-Bilska A T Reynolds L P Caton J S | 2007 | Journal of Animal Science2007，85，10： | 1 |
| 12 | Effects of selenium supply and dietary restriction on maternal and fetal metabolic hormones in pregnant ewe lambs 显示文摘 | Ward M A Neville T L Reed J J Taylor J B Hallford D M Soto- Navarro S A Vonnahme K A Redmer D A Reynolds L P Caton J S | 2008 | Journal of Animal Science2008，86，5： | 1 |
| 13 | Effects of level and source of dietary selenium on maternal and fetal body weight, visceral organ mass, cellularity estimates, and jejunal vascularity in pregnant ewe Iambs 显示文摘 | Neville T L Ward M A Reed J J Soto-Navarro S A Julius S L Borowiez P P Taylor J B Redmer D A Reynolds L P Caton J S | 2008 | Journal of Animal Science2008，86，4： | 1 |
| 14 | Haemolyticuraemic syndrome with thrombotic microangiopathy of the retina following cytomegalovirus infection:postmortem findings Postgrad显示文摘 | Caton B Diaz de Otazu R Aldamaz-Echebarria M | 1993 | Postgrad Med J1993，69，841： | 1 |
| 15 | Forage and nitrogen yield of barley-pea and oat-pea intercrops 显示文摘 | Cart P M Martin G B Caton J S | 1998 | Agronomy Journal1998，90，： | 1 |
| 16 | Expression of gap junctional connexin proteins in ovine fetal ovaries : effects of maternal diet 显示文摘 | Grazul - Bilska A T Vnnnahme K A Bilski J J Borowczyk E Soni D Mikkelson B Johnson M L Reynolds L P Redmer D A Caton J S | 2011 | Domestic Animal Endocrinology2011，41，4： | 1 |
| 17 | Stress ratio effects on small fatigue crack growth in Ti-6Al-4V显示文摘 | CATON M J JOHN R PORTER W J | 2012 | International Journal of Fatigue2012，38，： | 1 |
| 18 | A retrospective study of untreated orbital blow out fractures显示文摘 | CATONE G A MORRISSETTE M P CARLSON E R | 1998 | J Oral Maxillofac Surg1998，46，： | 1 |
| 19 | Halotoler- ant aerobic heterotrophic bacteria from the greatsah plains ofoklahoma 显示文摘 | CATON T M WITTE L R NGYUEN H D | 2004 | Microbial Ecology2004，48，： | 1 |
| 20 | Influence of pregnancy on body weight, ruminal characteristics, and visceral organ mass in beef heifers 显示文摘 | SCHEAFFER A N CATON J S BAUER M L | 2001 | J Anim Sci2001，79，9： | 1 |
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