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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 3 | Sequential(step-by-step) detection,identification and quantization of extra virgin olive oil adulteration by chemo metric treatment of chromatographic profiles显示文摘 | CAPOTE F P JIMINEZ J R LUQUE de CASTRO M D | 2007 | Analytical and Bioanalytical Chemistry2007，338，8： | 1 |
| 4 | Mechanical alloying of Cu-Mo powder mixtures and thermodynamics study of solubility 显示文摘 | MARTINEZ V P AGUILAR C MARIN J ORDONEZ S CASTRO F | 2007 | Materials Letters2007，61，45： | 1 |
| 5 | An improved RTN continuous-time formulation for the short-term scheduling of multipurpose batch plants 显示文摘 | CASTRO P BARBOSA-Povoa A P F D MATOS H | 2001 | Industrial and Engineering Chemistry Research2001，40，9： | 1 |
| 6 | Detection and characterization of Pasteuria 16S rRNA gene sequences from nematodes and soils显示文摘 | Duan Y P Castro H F Hewlett T E | 2003 | International Journal of Systematic and Evolutionary Microbiology2003，53，10： | 1 |
| 7 | Part 3 : Burst tests of pipeline with extensive longitudinal metal loss 显示文摘 | Freire J L F Vieira R D Castro J T P | 2006 | Experimental Techniques2006，30，6： | 1 |
| 8 | Alternative statistical and theoretical analysis of fluorophilicity显示文摘 | DUCHOWICZ P R FERNANDEZ F M CASTRO E A | 2004 | Journal of Fluorine Chemistry2004，125，： | 1 |
| 9 | Mechanical alloying of Cu-Mo powder mixtures and thermodynamic study of solubility显示文摘 | MARTINEZ V D P AGUILAR C MAP J-N J ORDONEZ S CASTRO F | 2007 | Material Letters2007，61，： | 1 |
| 10 | Full scale self- propulsion computations using diseretized propeller for the KRISO container ship KCS显示文摘 | Castro A M Carrica P M Stern F | 2011 | Computers & Fluids2011，51，1： | 1 |
| 11 | Learning ensembles of neural networks by means of a bayesian artificial immune system显示文摘 | Castro P A Von Zuben F J | 2011 | IEEE Transactions on Neural Networks2011，22，2： | 1 |
| 12 | Physical and chemical characterization of metal finishing industrial wastes 显示文摘 | MAGALHAES J M SILVA J E CASTRO F P | 2005 | Journal of Environment Management2005，75，2： | 1 |
| 13 | Circulating levels of endothelial function are modulated by di- etary monounsaturated fat显示文摘 | Perez-Jimenez F Castro P Lopez-Miranda J | 1999 | Atherosclerosis1999，145，： | 1 |
| 14 | Full scale self-propulsion computations using diseretized propeller for the KRISO container ship KCS 显示文摘 | Castro A M Carrica P M Stern F | 2011 | Computers & Fluides2011，51，1： | 1 |
| 15 | Anatomical, clinical and radiological delineation of target volumes in breast cancer radiotherapy planning:individual variabili- ty,questions and answers 显示文摘 | Castro Pena P Kirova YM Campana F | 2009 | Br J Radiol2009，82，979： | 1 |
| 16 | Phytoremediation of polyaromatic hydrocarbons,anilines and phenols显示文摘 | Harvey P J Campanella B F Castro P M L | 2002 | Environ Sci Pollut Res2002，9，1： | 1 |
| 17 | Comparison of generative statistical models for the LMS channel显示文摘 | FONTAN F P CASTRO M A V ENJAMO C | 2002 | IEEE VTC2002，，： | 1 |
| 18 | Fluorescent in situ hybridization to amphioxus chromosomes显示文摘 | Castro L F Holland P W | | 0，，： | 1 |
| 19 | External polyacrylate-coating as alternative material for preparation of photopolymerized sol-gel monolithic column 显示文摘 | Vaz F A S Castro P M Molina C | 2008 | Talanta2008，76，： | 1 |
| 20 | Learning ensembles of neural networks by means of a bayesian artificial immune system显示文摘 | Castro P A D Von Zuben F J | | 0，，02： | 1 |
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