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| 1 | Cyclooxygenase-2 and the inflammogenesis of breast cancer显示文摘Cohesive scientific evidence from molecular, animal, and human investigations supports the hypothesis that constitutive overexpression of cyclooxygenase-2(COX-2) is a ubiquitous driver of mammary carcinogenesis, and reciprocally, that COX-2 blockade has strong potential for breast cancer prevention and therapy. Key findings include the following:(1) COX-2 is constitutively expressed throughout breast cancer development and expression intensifies with stage at detection, cancer progression and metastasis;(2) essential features of mammary carcinogenesis(mutagenesis, mitogenesis, angiogenesis, reduced apoptosis, metastasis and immunosuppression) are linked to COX-2-driven prostaglandin E2(PGE-2) biosynthesis;(3) upregulation of COX-2 and PGE-2 expression induces transcription of CYP-19 and aromatase-catalyzed estrogen biosynthesis which stimulates unbridled mitogenesis;(4) extrahe-patic CYP-1B1 in mammary adipose tissue converts paracrine estrogen to carcinogenic quinones with mutagenic impact; and(5) agents that inhibit COX-2 reduce the risk of breast cancer in women without disease and reduce recurrence risk and mortality in women with breast cancer. Recent sharp increases in global breast cancer incidence and mortality are likely driven by chronic inflammation of mammary adipose and upregulation of COX-2 associated with the obesity pandemic. The totality of evidence clearly supports the supposition that mammary carcinogenesis often evolves as a progressive series of highly specific cellular and molecular changes in response to induction of constitutive overexpression of COX-2 and the prostaglandin cascade in the 'inflammogenesis of breast cancer'. | Randall E Harris Bruce C Casto Zachary M Harris | 2014 | World Journal of Clinical Oncology2014，5，4： | 15 |
| 2 | Nicotine-induced upregulation of antioxidant protein Prx 1 in oral squamous cell carcinoma显示文摘Nicotine is a source of exogenous oxidative stress, which is associated with the pathogenesis of numerous diseases including oral squamous cell carcinoma (OSCC), whereas an antioxidant protein, peroxiredoxin 1 (Prx 1), plays an important role in the modulation of this condition. This study was to investigate the association between Prx 1 and tobacco-induced oxidative stress. The expression of Prx 1 and GST in OSCC Tca8113 cells, which were pre-treated with nicotine, was determined. In the present study, MTT assay, reactive oxygen species (ROS) assay, RT-PCR and Western blot analyses, respectively, were conducted to assess cell viability, ROS level, and expression level of Prx 1 and GST in nicotine-treated Tca8113 cells. Nuclear factor kappa B (NF- B) expression was detected by immuno-fluorescence. Our results showed the growth of Tca8113 cells was increased in a dose-dependent manner when cells were treated with nicotine at concentrations from 0.1 to 10 mol/L, but the proliferation of the cells decreased at 100 mol/L. ROS levels increased in all groups treated with nicotine at concentrations of 0.1, 1, 10, or 100 mol/L for 24h. Prx 1 and GST mRNA and protein expression were up-regulated in cells treated with nicotine for the same time at different concentrations or at the same concentration for different times (P<0.05). NF-B was translocated from cytoplasm to nucleus, the expression of NF- B was increased in nucleus. These results suggest that up-regulation of Prx1 expression appears to be associated with tobacco-induced oxidative stress, which may play an important role in the pathogenesis of OSCC. | ZHAO YanHua ZHANG Min YAN Fei CASTO Bruce C TANG XiaoFei | 2013 | Chinese Science Bulletin2013，58，16： | 7 |
| 3 | Isokinetic trunk flexion-extension protocol to assess trunk muscle strength and endurance:Reliability,learning effect,and sex differences显示文摘Purpose:The purpose of this study was to examine the reliability and the learning effect of an isokinetic trunk flexion-extension protocol designed to simultaneously assess trunk muscle strength and endurance.In addition,the effect of the participants’sex on the reliability data was examined.Methods:Fifty-seven healthy and physically active young men(n=28)and women(n=29)performed the isokinetic protocol 5 times,separated by a week between each of the first 4 sessions and by a month between the last 2 sessions.The protocol consisted of performing 4 trials of 15 maximum flexion-extension concentric exertions at 120°/s(range of trunk motion=50°).The absolute and relative peak torque and total work were calculated to assess trunk flexion and extension strength.In addition,endurance ratio,modified endurance ratio,fatigue final ratio,recovery ratio,and modified recovery ratio variables were used for the assessment of trunk muscle endurance in both directions.Results:Regarding the absolute reliability,no relevant changes were found between paired-comparison sessions for most strength and endurance variables,except for total work and relative total work variables in the flexion movement in both sexes.In addition,the typical error of the isokinetic variables was lower than 10%in both males and females,and minimum detectable changes ranged from 7%to 20%,with a tendency to be higher in females and in endurance variables.The strength variables showed high-to-excellent intraclass correlation coefficients(ICCs;>0.74);however,for the endurance variables only the endurance ratio and the modified endurance ratio obtained moderate-to-high ICC values(0.57 | María Pilar García-Vaquero David Barbado Casto Juan-Recio Alejandro López-Valenciano Francisco J.Vera-Garcia | 2020 | Journal of Sport and Health Science2020，9，6： | 4 |
| 4 | Biomechanical correlations of lesions assocjated with traumatic diseases of the anterjor cruciate ligament:Analysis with MR显示文摘 | Demaria M Barbiera F Lo Casto A | 1996 | Radiol Med Torino1996，91，6： | 1 |
| 5 | Postoperative feeding : a clinical review 显示文摘 | Johnson Casto C Krammer J Drake J | 2000 | Obstet Gynecol Surv2000，55，9： | 1 |
| 6 | Intra-arterial thrombolysis in acute ischemic stroke:experience with a superselective catheter embedded in the clot显示文摘 | Casto L Cavemi L Camerlingo M | 1996 | J Neurol Neurosurg Psychiatry1996，60，： | 1 |
| 7 | Interventional treatment of sialoliths in main salivary glands 显示文摘 | Cannizzaro F Lo Casto A | 2002 | Radiol Med(Torino)2002，103，4： | 1 |
| 8 | Estrogen content and metabolism in human breast tumor tissue and cells显示文摘 | Lo Casto M Granata OM | 1996 | Ann N Y Acad Sci1996，784，： | 1 |
| 9 | Food restriction attenuates the blood pressure response to paraventricular hypothalamie nuctei lesions in aortic coarctation hypertension 显示文摘 | VanNess JM Casto RM DeMaria JE | 1998 | Brain Res1998，792，2： | 1 |
| 10 | Doppler microembofic sig- nals predict ischemic recurrences in symptomatic carotid stenosis 显示文摘 | Censori B Partziguian T Casto L | 2000 | Acta Neurol Scand2000，101，5： | 1 |
| 11 | Effects of central leptin administration on blood pressure in normotensive rats显示文摘 | Casto RM Vanness JM Overton JM | 1998 | Neurosci Lett1998，246，1： | 1 |
| 12 | Adeno-associated defective virus particle显示文摘 | Atchison R W Casto B C Hammon M | 1965 | Science1965，49，： | 1 |
| 13 | Effects of centralleptin administration on blood pressure in normotenive nits显示文摘 | CASTO R M V AN NESS J M OVERTON J M et at | 1998 | Neurosci Lett1998，246，1： | 1 |
| 14 | Rapid microsatellite identification from illumina pairedend genomic sequencing in two birds and a snake显示文摘 | Castoe T A Poole A W deKoning A P | 2012 | PLoS ONE2012，7，30： | 1 |
| 15 | Recurrence after first cerebral infarction in young adults显示文摘 | Camerlingo M Casto L Censori B | 2000 | Acta Neurologica Scandinavica2000，102，02： | 1 |
| 16 | Characterization of X-linked SNP genotypic variation in globally distributed human populations显示文摘 | Casto AM Li JZ Absher D | 2010 | Genome Bial2010，11，1： | 1 |
| 17 | Essential thrombocytemia and ischemic Stroke:report of six case 显示文摘 | Camerlingo M Finazzi G | 1994 | ltal J Neurol Sci1994，15，7： | 1 |
| 18 | Development of a multi-organ rat model for evaluating chemopreventive agents:efficacy of indole-3-carbinol显示文摘 | Casto B Ralston S | 2002 | Carcinogenesis2002，23，2： | 1 |
| 19 | A pharmacokinetic study of modazolam into dogs nasal drop vs atomizer administration显示文摘 | HERRY R J RUANO N CASTO D | 1998 | Pedatr dent1998，20，5： | 1 |
| 20 | Effects of central leptin administration on blood presaure in nomotensive rats显示文摘 | Casto RM VanNesa J M Overton J M | 1998 | Neurosci lett1998，246，1： | 1 |
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