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	题名	作者	年代	出处	被引量
1	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.	Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea	2008	World Journal of Gastroenterology2008，14，18：	2
2	Pectin esterase gene family in strawberry fruit:study of FaPE1, a ripening-specific isoform显示文摘	Castillejo C de la Fuente J I Iannetta P	2004	J Exp Bot2004，55，398：	1
3	Mortality and ambient fine particles in southwest Mexico City, 1993-1995显示文摘	Borja-Aburto VH Castillejos M Gold DR	1998	Environ Health Perspect1998，106，：	1
4	Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia显示文摘	Jimenez-Velasco A Castillejo J Roman-Gomez J	2004	Blood2004，104，8：	1
5	ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodies 显示文摘	Josephson CD Castillejo MI Grima K	2010	Transfus Apher Sei2010，42，1：	1
6	Pectin esterase gene family in strawberry fruit:study of FaPE1,a ripening-specific isoform显示文摘	CASTILLEJO C DE LA FUENTE J I IANNETTA P BOTELLA M A VALPUESTA V	2004	J Exp Bot2004，55，398：	1
7	Differential expression proteomics to investigate responses and resistance to Orobanche crenata in Medicago truncatula 显示文摘	CASTILLEJO M A MALDONADO A M DUMAS-GAUDOT E	2009	BMC Genomics2009，10，：	1
8	Mortality and ambient fine particles in southwest Mexico City, 1993 - 1995 显示文摘	Borja AburtoVH Castillejos M Gold DR	1998	Environ Health Perspect1998，106，12：	1
9	Effects of dose and adaptation time of a specific blend of essential oil compounds on rumen fermentation 显示文摘	Castillejos L Calsamiglia S Ferret A	2007	Animal Feed Science and Technology2007，132，34：	1
10	Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤ 1500 g) using cytomegalovirus-seronegative and leukoreduced transfusions显示文摘	Josephson CD Castillejo MI Caliendo AM	2011	Transfus Med Rev2011，25，2：	1
11	Proteomic analysis of Pinus needles : 2 - DE map and protein identification by LC/MS/ MS and substitution- tolerant database searching显示文摘	Valledor L Castillejo M A Lenz C	2008	Journal of Pro- teome Research2008，7，7：	1
12	Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia 显示文摘	Roman-Gomez J Jimenez-Velasco A Castillejo JA	2004	Blood2004，104，8：	1
13	ABO-mismatched platelet transfusions:strategies to mitigate patient exposure to naturally occurring hemolytic antibodies显示文摘	Josephson CD Castillejo MI Grima K		0，，01：	1
14	Neu- roendocrine small cell carcinoma of the uterine cervix 显示文摘	Reig Castillejo A Membrive Conejo I Foro Arnalot P	2010	Clin Transl Oncol2010，12，7：	1
15	The strawbeery gene FaGAST affects plant growth through inhibition of cell elongation显示文摘	DE LA FUENTE J I AMAYA I CASTILLEJO C SANCHEZ-SEVILLA J F QUESADA M A BOTELLA M A VALPUESTA V	2006	Journal of Experimental Botany2006，57，10：	1
16	Dissociative Ionization of Halogenated Ethylenes in Intense Femtosecond Laser Pulses显示文摘	Martin M Nalda R	2002	Chem Phys Lett2002，353，：	1
17	Air pollution and infant mortality in Mexico City显示文摘	Loomis D Castillejos M Gold DR	1999	Epidemiol1999，10，：	1
18	Model properties relevant to laser ablation of moderately absorbing polymers 显示文摘	Lazare S Aboudi I E Castillejo M	2010	Applied Physics A: Materials Science & Processing2010，101，1：	1
19	The role of hyaluronic acid m SEB-induced acute lung inflammation 显示文摘	UCHAKINA O N CASTILLEJO C M BRIDGES C C	2013	Clin Immunol2013，146，1：	1
20	Experi- mental and numerical investigation of fluid flow and mixing in pachuca tanks显示文摘	Rodriguez M E Castillejos E AH Acosta G FA	2007	Metallurgical and Materials Transac- tions B2007，38，4：	1

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