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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | 过度诊断、伦理学和电车难题显示文摘在英国、美国、加拿大及其他一些地方对乳房X光检查一直存在争议,对前列腺癌、慢性肾病、注意缺陷多动障碍(ADHD)以及其他许多状况的过度诊断也存在争议。人们迫不得已选择担心过度诊断,是由于有证据证明其危害大于受益。不过,并非人人都同样认为这是迫不得已的选择。这也可能是因为对证据、利益冲突方面存在分歧,或由于认知偏差。造成分歧的另一个可能原因是,有些人可能并不认为受益和伤害是最重要的考虑因素。这种比较是伦理规范的核心。从广义上讲,功利主义伦理学家认为,假设有几种选择,我们应该选择在计算中确保每个人同等重要时,能产生总体结果最佳的选项。非后果论伦理学家则认为,其他伦理学问题,如权利、义务或尊重人的尊严或自主性,是更重要的。 | Stacy M Carte 翟晓梅(译) | 2019 | 中国医院院长2019，0，10： | 2 |
| 3 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 4 | Endothehns as autocrine regulators of tumor cell growth显示文摘 | Bagnato A Cart K | 1998 | Tren&Endocrin Met1998，9，9： | 1 |
| 5 | Liver injury durying acute Pancreatitis:the role of pancreatitis associated as citiefluid(PAAF),p-38 M APK,and caspase 3 in inducing ghepatocy teapoptosis显示文摘 | Adam Fier Yvette Carte | 2003 | The Society for Surgery of the Alimentary Tract2003，7，2： | 1 |
| 6 | Biomedical potential of marine natural products显示文摘 | Carte B K | 1996 | Bioscience1996，46，4： | 1 |
| 7 | The asbestinins, a novel class of diterpenes from the gorgonian Briareum asbestinum 显示文摘 | Stierle D B Carte B Faulkner D J | 1980 | J Am Chem Soc1980，102，： | 1 |
| 8 | Surgical treatment of the intra - articular calcaneal fracture显示文摘 | Cart JR | 1994 | Orthop clin North Am1994，25，4： | 1 |
| 9 | Antitumor reactivity of anti-CD3/antiCD28 bead-activated lymphoid cells: implications for cell therapy in a murine model 显示文摘 | Ito F Cart A Svenssson H | 2003 | J Immunother2003，26，3： | 1 |
| 10 | Structural and morphometric analysis of murine small intestine after indomethacin administration 显示文摘 | Ettarh RR Cart KE | 1993 | Scand J Gastroenterol1993，28，9： | 1 |
| 11 | Surface interpolation with radial basis functions for medical imaging显示文摘 | Jonathan C Cart Richard Fright W | 1997 | IEEE Transactions on Medical Imaging1997，16，1： | 1 |
| 12 | Customer Re- purchase Intention: a General Structural Equation Model 显示文摘 | Hellier P K Geursen G M Cart R A | 2003 | European Journal of Marketing2003，37，1112： | 1 |
| 13 | Atherosclerotic plaque rupture in symptomatic carotid artery stenosis显示文摘 | Cart S Farb A Pearce WH | 1996 | J Vasc Surg1996，23，： | 1 |
| 14 | Control methods of inverter-interfaced distributed generators in a microgrid system显示文摘 | CHUNG ! Y LIU W CARTES D A | 2010 | IEEE Transactions on Industry Applications2010，46，3： | 1 |
| 15 | New clinical-practice guidelines for the management of pain in patients with cancer 显示文摘 | Jacox A Cart DB Payne R | 1994 | N Engl J Med1994，330，9： | 1 |
| 16 | A report on the first remote handling operations at JET 显示文摘 | Rolfe A C Brown P Carte P | 1999 | Fusion Engineering and Design1999，46，24： | 1 |
| 17 | Adverse effects of antiretroviral therapy显示文摘 | Cart A Cooper DA | 2000 | Lancet2000，356，9239： | 1 |
| 18 | Utilization of tannincontaining and tannin-free faba beans (Vicia faba) by young chicks:Effects of pelleting feeds on energy,protein and starch digestibility显示文摘 | Lacassagne L Francesch M Cart B | 1988 | Animal Feed Science1988，20，1： | 1 |
| 19 | Image selective smoothing and edge detection by nonlinear diffusion显示文摘 | Carte F Lions P L Morel J M | 1992 | SIAM J Numerical Analysis1992，29，1： | 1 |
| 20 | On the volumetric deformation of reconstituted soils 显示文摘 | Liu M D Carte J P | 2000 | International Journal for Numerical and Analytical Methods in Geomechanics2000，24，： | 1 |
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