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| 1 | Managements of recurrent hepatocellular carcinoma after liver transplantation: A systematic review显示文摘AIM: To investigate the efficacy(survival) and safety of treatments for recurrent hepatocellular carcinoma(HCC) in liver transplantation(LT) patients.METHODS: Literature search was performed on available online databases without a time limit until January 2015. Clinical studies describing survival after HCC recurrence in LT patients were retrieved for a fulltext evaluation. A total of 61 studies were selected: 13 case reports, 41 retrospective case series, and 7 retrospective comparative studies.RESULTS: Based on all included studies, the mean HCC recurrence rate was 16% of all LTs for HCC. A total of 1021 LT patients experienced HCC recurrence. The median time from LT to HCC recurrence was 13 mo(range 2-132 mo). The majority of patients(67%) presented with HCC extra-hepatic recurrences, involving lung, bone, adrenal gland, peritoneal lymph nodes, and rarely the brain. Overall survival after HCC recurrence was 12.97 mo. Surgical resection of localized HCC recurrence and Sorafenib for controlling systemic spread of HCC recurrence were associated with the higher survival rates(42 and 18 mo, res-pectively). However, Sorafenib, especially when combined with m TOR, was frequently associated with severe side effects that required dose reduction or discontinuation CONCLUSION: Management of recurrent HCC in LT patients is challenging and associated with poor prognosis independently of the type of treatment. | Nicola de'Angelis Filippo Landi Maria Clotilde Carra Daniel Azoulay | 2015 | World Journal of Gastroenterology2015，21，39： | 42 |
| 2 | Short-term clinical outcomes of laparoscopic vs open rectal excision for rectal cancer: A systematic review and metaanalysis显示文摘AIM To review evidence on the short-term clinical outcomes of laparoscopic(LRR) vs open rectal resection(ORR) for rectal cancer.METHODS A systematic literature search was performed using Cochrane Central Register, MEDLINE, EMBASE, Scopus, Open Grey and Clinical Trials.gov register for randomized clinical trials(RCTs) comparing LRR vs ORR for rectal cancer and reporting short-term clinical outcomes. Articles published in English from January 1, 1995 to June, 30 2016 that met the selection criteria were retrieved and reviewed. The Preferred Reporting Items for Systematic reviews and Meta-Analysis(PRISMA) statements checklist for reporting a systematic review was followed. Random-effect models were used to estimate mean differences and risk ratios. The robustness and heterogeneity of the results were explored by performing sensitivity analyses. The pooledeffect was considered significant when P < 0.05.RESULTS Overall, 14 RCTs were included. No differences were found in postoperative mortality(P = 0.19) and morbidity(P = 0.75) rates. The mean operative time was 36.67 min longer(95%CI: 27.22-46.11, P < 0.00001), the mean estimated blood loss was 88.80 ml lower(95%CI:-117.25 to-60.34, P < 0.00001), and the mean incision length was 11.17 cm smaller(95%CI:-13.88 to-8.47, P < 0.00001) for LRR than ORR. These results were confirmed by sensitivity analyses that focused on the four major RCTs. The mean length of hospital stay was 1.71 d shorter(95%CI:-2.84 to-0.58, P < 0.003) for LRR than ORR. Similarly, bowel recovery(i.e., day of the first bowel movement) was 0.68 d shorter(95%CI:-1.00 to-0.36, P < 0.00001) for LRR. The sensitivity analysis did not confirm a significant difference between LRR and ORR for these latter two parameters. The overall quality of the evidence was rated as high. CONCLUSION LRR is associated with lesser blood loss, smaller incision length, and longer operative times compared to ORR. No differences are observed for postoperative morbidity and mortality. | Aleix Martínez-Pérez Maria Clotilde Carra Francesco Brunetti Nicola de'Angelis | 2017 | World Journal of Gastroenterology2017，23，44： | 33 |
| 3 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 4 | Short- and long-term efficacy of endoscopic balloon dilation in Crohn's disease strictures显示文摘AIM:To evaluate short- and long-term efficacy of endoscopic balloon dilation in a cohort of consecutive patients with symptomatic Crohn's disease (CD)-related strictures. METHODS:Twenty-six CD patients (11 men; median age 36.8 year, range 11-65 years) with 27 symptomatic strictures underwent endoscopic balloon dilation (EBD).Both naive and post-operative strictures, of any length and diameter, with or without associated fistula were included. After a clinical and radiological assessment, EBD was performed with a Microvasive Rigiflex through the scope balloon system. The procedure was considered successful if no symptom reoccurred in the following 6 mo. The long-term clinical outcome was to avoid surgery. RESULTS:The mean follow-up time was 40.7 ± 5.7 mo (range 10-94 mo). In this period, forty-six EBD were performed with a technical success of 100%. No procedure-related complication was reported. Surgery was avoided in 92.6% of the patients during the entire follow-up. Two patients, both presenting ileocecal strictures associated with fistula, failed to respond to the treatment and underwent surgical strictures resection. Of the 24 patients who did not undergo surgery, 11 patients received 1 EBD, and 13 required further dilations over time for the treatment of relapsing strictures (7 patients underwent 2 dilations, 5 patients 3 dilations, and 1 patient 4 dilations). Overall, the EBD success rate after the first dilation was 81.5%. No difference was observed between the EBD success rate for naive (n = 12) and post-operative (n = 15) CD related strictures (P > 0.05). CONCLUSION:EBD appears to be a safe and effective procedure in the therapeutic management of CD-related strictures of any origin and dimension in order to prevent surgery. | Nicola de'Angelis Maria Clotilde Carra Osvaldo Borrelli Barbara Bizzarri Francesca Vincenzi Fabiola Fornaroli Giuseppina De Caro Gian Luigi de'Angelis | 2013 | World Journal of Gastroenterology2013，19，17： | 4 |
| 5 | Expression d COX- 1,(213X- 2, and inducible nitricoxide synthase protein in human gastric antrum with Helicobacter pylon infection显示文摘 | Franco L Talaminl G Carra G | 1999 | Prostaglandins Other Lipid Mediat1999，58，1： | 1 |
| 6 | Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKa and CaMKKb mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor显示文摘 | Jonathan Vinet Serena Carra Joan MC Blom | 2004 | Neuropharmacology2004，，47： | 1 |
| 7 | Human interleukin-2 promotes proliferation of activated B cells via surface recepors similar to those of activated T cells显示文摘 | Mingari MC Gerosa F Carra G | 1984 | Nature1984，312，： | 1 |
| 8 | Antibody response to pneumococcal vaccine in children receiving bone marrow transplantation显示文摘 | Avanzini M A Carra A M Maccario R | | 0，，： | 1 |
| 9 | Human interleukin 2promotes prolferation of B cell Viasurface, Recpetors similar to those of activited T cellls显示文摘 | Mingani MC Gerosa F Carra G | 1984 | Nature1984，312，： | 1 |
| 10 | Immunization with Haemophilus influenzae type b conjugate vaccine in children given bone marrow transplantation: comparison with healthy age-matched controls显示文摘 | Avanzini M A Carra A M Maccario R | | 0，，： | 1 |
| 11 | Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain:a randomized,double-blind,placebo-controlled,crossover study显示文摘 | Carra DB Goudasa LC Denman WT | | 0，，1： | 1 |
| 12 | Transien resistance of influenz avirus to interferon action attributed to random multiple packaging and activity of NS genes显示文摘 | SEKELLICK M J CARRA S A BOWMAN A | 2000 | Journal of Interferon & Cytokine Research2000，20，11： | 1 |
| 13 | Transient resistance of influenza virus to interferon action attributed to random multiple packaging and activity of NS genes显示文摘 | Sekellick M J Carra S A Bowman A | 2000 | Journal of Interferon & Cytokine Research2000，20，11： | 1 |
| 14 | Development of PCR primers from internal transcribed spacer region 2 for detection of phytophthora species infecting potatoes 显示文摘 | TOOLEY P W BUNYARD B A CARRAS M M | 1997 | Applied and Environmental Microbiology1997，63，4： | 1 |
| 15 | Cervical myelopathy caused by developmental stenosis of the spinal canal显示文摘 | EpsteinJA Carras R Hyman RA | 1979 | J Neurosurg1979，51，： | 1 |
| 16 | Myelopathy in cervical spondylosis with vertebra lsubluxation and hyperlodosis显示文摘 | Epstein JA Carras R Epstein BS | 1970 | J Neurosurg1970，32，： | 1 |
| 17 | Myelopathy in cervical spondylosis with vertebral subluxation and hyperlordosis 显示文摘 | Epstein JA Carras R Epstein BS | 1970 | J Neurosurg1970，32，4： | 1 |
| 18 | Modularized Smad-regulated TGFβ signaling pathway显示文摘 | Li Y Wang M Carra C | 2012 | Math Biosci2012，240，2： | 1 |
| 19 | Long-term bending performance and service life prediction of puhruded glass fibre reinforced polymer composites 显示文摘 | CARRA G CARVELLI V | 2015 | Compos Struct2015，127，： | 1 |
| 20 | Argentine Patagonia: prevalence and clinical features of multiple sclerosis 显示文摘 | Meleon MO Gold L Carra A | 2008 | Mult Seler2008，14，5： | 1 |
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