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| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | The potential of natural products for targeting PPARα显示文摘Peroxisome proliferator activated receptors(PPARs) α,-γ and-β/δ are ligand-activated transcription factors and members of the superfamily of nuclear hormone receptor. These receptors play key roles in maintaining glucose and lipid homeostasis by modulating gene expression. PPARs constitute a recognized druggable target and indeed several classes of drugs used in the treatment of metabolic disease symptoms, such as dyslipidemia(fibrates, e.g. fenofibrate and gemfibrozil) and diabetes(thiazolidinediones, e.g. rosiglitazone and pioglitazone) are ligands for the various PPAR isoforms. More precisely, antidiabetic thiazolidinediones act on PPARγ, while PPARα is the main molecular target of antidyslipidemic fibrates. Over the past few years, our understanding of the mechanism underlying the PPAR modulation of gene expression has greatly increased. This review presents a survey on terrestrial and marine natural products modulating the PPARα system with the objective of highlighting how the incredible chemodiversity of natural products can provide innovative leads for this 'hot' target. | Daniela Rigano Carmina Sirignano Orazio Taglialatela-Scafati | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Extensive clinical experi- ence : relative prevalence of different androgen excess disorders in 950 women referred because of clinical hyperandrogenism显示文摘 | Carmina E Rosato F Janni A | 2006 | J Clin Endocrinol Metab2006，91，1： | 1 |
| 5 | The importance of diagnosing the polycystic ova- ry syndrome 显示文摘 | Lobo RA Carmina E | 2000 | Ann Intern Med2000，132，12： | 1 |
| 6 | Enhanced discrimination of African swine fever virus isolates through nueleotide sequencing of the p54, p72, and pB602L(CVR)显示文摘 | Carmina G Dufton M M Joseph M M | 2009 | Virus Genes2009，38，： | 1 |
| 7 | Dignosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines显示文摘 | Carmina E | 2004 | Minerva Ginecol2004，56，1： | 1 |
| 8 | Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society显示文摘 | Dewailly D Lujan ME Carmina E | 2014 | Hum Rprod Update2014，20，3： | 1 |
| 9 | Difference in dyslipidemia between American an Italian women with polycystic ovary syndrome显示文摘 | Essah PA Nestler JE Carmina E | 2008 | J Indocri Nol Invest2008，31，1： | 1 |
| 10 | Definition and significance of polyeystie ovarian morphology a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society 显示文摘 | Dewailly D Lujan ME Carmina E | 2014 | Hum Reprod Update2014，20，： | 1 |
| 11 | Definition and significance ofpolycystic ovarian morphology : a task force report from the androgenexcess and polycystic ovary syndrome society 显示文摘 | Dewailly D Lujan ME Carmina E | 2014 | Human Reproduc-tion Update2014，20，3： | 1 |
| 12 | The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report显示文摘 | Azziz R Carmina E Dewailly D | 2009 | Fertil Steril2009，91，2： | 1 |
| 13 | The androgen excess and PCOS Society criteria for the polycystic ovary syndrome:the complete task force report显示文摘 | Azziz R Carmina E Dewailly D | 2009 | Fertil Steril2009，91，2： | 1 |
| 14 | Correlates of increased lean muscle mass in women with polycystic ovary syndrome 显示文摘 | Carmina E Guastella E Longo RA | 2009 | Eur J Endoerinol2009，161，4： | 1 |
| 15 | The Androgen Excess and P- COS Society criteria for the polycystic ovary syndrome: the complete task force report显示文摘 | Azziz R Carmina E Dewailly D | 2008 | Fertil Steril2008，91，2： | 1 |
| 16 | Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome显示文摘 | Carmina E Lobo RA | | 0，，03： | 1 |
| 17 | Clinical and endocrine characteristics of the main polycystic ovary syndrome pheno- types 显示文摘 | Guastella E Longo RA Carmina E | 2010 | Fertil Steril2010，94，： | 1 |
| 18 | The diagnosis of polycystic ovary syndrome in adolescents显示文摘 | Carmina E Oberfield SE Lobo RA | 2010 | Am J Obstet Gynecol2010，203，3： | 1 |
| 19 | Clinical and endocrine characteristics of the main polycystic ovary syn- lrome phenotypes 显示文摘 | GUASTELLA E LONGO R A CARMINA E | 2010 | Fertility and Sterility2010，94，6： | 1 |
| 20 | Difference in dyslipidemia be- tween American and Italian women with polycystic ovary syndrome 显示文摘 | Essah PA Nestler JE Carmina E | 2008 | J Endocrinol Invest2008，31，1： | 1 |
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