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| 1 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 3 | Long-term neurotoxicity of chlorpyrifos:spatial learning impairment on repeated acquisition in a water maze显示文摘 | Canadas F Cardona D Davila E | 2005 | Toxicol Sci2005，85，2： | 1 |
| 4 | Group A streptococcal infections and tic disorders in an Italian pediatric population显示文摘 | Cardona F Orefici G | 2001 | J Pediatr2001，138，1： | 1 |
| 5 | Long-term neurotoxicity of chlorpyrifos: spatial learning impairment on repeated acquisition in a water maze显示文摘 | CANADAS F CARDONA D DAVILA E | 2005 | Toxicol Sci2005，85，2： | 1 |
| 6 | Human recombinant activated protein C for severe sepsis 显示文摘 | Marti-Carvajal A Salanti G Cardona A F | 2007 | Cochrane Database Syst Rev2007，，00： | 1 |
| 7 | Demonstration of a left atrial input to the atrioventricular node in humans显示文摘 | Gonzalez MD Contreras LJ Cardona F | 2002 | Circulation2002，106，： | 1 |
| 8 | On thermoeconomics of energy systems at variable load conditions: Integrated optimization of plant design and operation显示文摘 | Piacentino A Cardona F | 2007 | Energy Conversion & Management2007，48，： | 1 |
| 9 | Geological and en- vironmental implications of the evaporite karst in Spain 显示文摘 | Gutierrez F Calaforra J M Cardona F | 2008 | En- vironmental Geology2008，53，5： | 1 |
| 10 | Group A streptococcal infections and tic disorders in an Italian pediatric population显示文摘 | Cardona F Orefici G | 2001 | J Pediatr2001，138，1： | 1 |
| 11 | Cure kinetic study of epoxidized hemp oil cured with a multiple catalytic system显示文摘 | Manthey N W Cardona F Aravinthan T | 2012 | Journal of Applied Polymer Science2012，125，2： | 1 |
| 12 | Contribution of polymorphisms in the apolipoprotein AI-CⅢ-AIV cluster to hyperlipidaemia in patients with gout显示文摘 | Cardona F Tinahones FJ Col antes E | | 0，，： | 1 |
| 13 | The synthesis of an N-lobe noncircular gear using Bezier and B-spline nonparametric curve on the design of its displacement law显示文摘 | Quintero Riaza H F Cardona Foix S Jordi Nebot L | | 0，，09： | 1 |
| 14 | Contribution of polymorphisms in the apolipoprotein AI-C Ⅲ-AIV cluster to hyperlipidaemia in patients with gout显示文摘 | Cardona F Tinahones FJ Collantes E | 2005 | Ann Rheum Dis2005，64，1： | 1 |
| 15 | Energy saving in two-stage reverse osmosis systems coupled with uhrafiltration processes 显示文摘 | Cardona E Piacentino A Marchese F | 2005 | Desalination2005，184，1： | 1 |
| 16 | The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates显示文摘 | Cardona F Tinahones FJ Collantes E | 2003 | Rheumatology2003，42，3： | 1 |
| 17 | Estradiol upregulates Bcl - 2 expression in adult brain neurons显示文摘 | Garcia - Segura LM Cardona - Gomez P Naftolin F | 1998 | Neuroreport1998，9，3： | 1 |
| 18 | A novel ap- proach for the improvement of stress resistance in wine yeasts 显示文摘 | Cardona F Carrasco P Perez-Ortin JE | 2007 | International Journal of Food Microbiology2007，114，1： | 1 |
| 19 | Impact of the gut mierobiota on the development of obesity and type 2 diabetes mellitus 显示文摘 | MORENO - INDIAS I CARDONA F TINAHONES F J | 2014 | Front Mierobiol2014，5，2： | 1 |
| 20 | Performance evaluation of CHP hybrid seawater desalination plants显示文摘 | Cardona E Piacentino A Marchese F | 2007 | Desalination2007，205，123： | 1 |
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