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| 1 | Clinical impact of selective transarterial chemoembolization on hepatocellular carcinoma:A cohort study显示文摘AIM:To prospectively evaluate the short and long term clinical impact of selective transarterial chemoembolization (TACE) on liver function in patients with hepatocellular carcinoma (HCC).To assess side effects in relation to treatments.To analyze the overall survival and HCC progression free survival probability. METHODS:One hundred and seventeen cirrhotic patients with HCC were enrolled.Baseline liver function included Child-Pugh score and serum levels of alanineaminotransferase (ALT),prothrombin time(PT)and bilirubin.According to Cancer Liver Italian Program (CLIP) and Barcelona Clinic Liver Cancer (BCLC) staging systems,71 patients were eligible for TACE; 32 had previously received treatment for HCC.No significant differences in liver function were observed between previously treated and not treated patients. TACE was performed by selective catheterization of the arteries nourishing the lesions.While hospitalized, patient sunder went clinical,hematologicand ultrasonographic assessments.One month after TACE a CT scan was performed to assess tumor response. A second TACE was performed'on demand'.Liver function tests were checked in all patients every four months.RESULTS:After first TACE,the mean Child-Pugh score increased from a mean baseline 5.62±1.12 to 6.11±1.57 at discharge time (P<0.0001),decreasing after four months to 5.81±0.73 (not significant).ALT,PT and bilirubin significantly (P<0.0001)increased 24 h after TACE and progressively decreased until discharge. After the second TACE,variations in Child-Pugh score,ALT,PT and bilirubin were comparable to that described after the first TACE.No major complications were observed.The mean follow-up was 14.7±6.3 mo (median:16 mo).Only one patient died.No other patient experienced important long term worsening of clinical status.The overall survival probability at twenty-four months was 98.18%with a correspondent HCC progression free survival probability of 69%. CONCLUSION:Selectiv TAC Emayproduce significant,but transitory increases in ALT values, with no major impact on liver function and Child-Pugh score.Preservation of liver function is achievable also in patients previously treated with other therapeutic modalities and in patients undergoing multiple TACE cycles.Liver function can remain stable in the long-term, with optimal medium term survival.This result can be achieved through rigorous patient selection on the basis of tumour characteristics and clinical conditions. | Rodolfo Sacco Marco Bertini Pasquale Petruzzi Michele Bertoni Irene Bargellini Giampaolo Bresci Graziana Federici Luigi Gambardella Salvatore Metrangolo Giuseppe Parisi Antonio Romano Antonio Scaramuzzino Emanuele Tumino Alessandro Silvestri Emanuele Altomare Claudio Vignali Alfonso Capria | 2009 | World Journal of Gastroenterology2009，15，15： | 7 |
| 2 | Endotics system vs colonoscopy for the detection of polyps显示文摘AIM: To compare the endotics system (ES), a set of new medical equipment for diagnostic colonoscopy, with video-colonoscopy in the detection of polyps. METHODS: Patients with clinical or familial risk of colonic polyps/carcinomas were eligible for this study. After a standard colonic cleaning, detection of polyps by the ES and by video-colonoscopy was performed in each patient on the same day. In each single patient, the assessment of the presence of polyps was performed by two independent endoscopists, who were randomly assigned to evaluate, in a blind fashion, the presence of polyps either by ES or by standard colonoscopy. The frequency of successful procedures (i.e. reaching to the cecum), the time for endoscopy, and the need for sedation were recorded. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the ES were also calculated. RESULTS: A total of 71 patients (40 men, mean age51.9 ± 12.0 years) were enrolled. The cecum was reached in 81.6% of ES examinations and in 94.3% of colonoscopies (P = 0.03). The average time of endoscopy was 45.1 ± 18.5 and 23.7 ± 7.2 min for the ES and traditional colonoscopy, respectively (P < 0.0001). No patient required sedation during ES examination, compared with 19.7% of patients undergoing colonoscopy (P < 0.0001). The sensitivity and specificity of ES for detecting polyps were 93.3% (95% CI: 68-98) and 100% (95% CI: 76.8-100), respectively. PPV was 100% (95% CI: 76.8-100) and NPV was 97.7% (95% CI: 88-99.9). CONCLUSION: The ES allows the visualization of the entire colonic mucosa in most patients, with good sensitivity/specificity for the detection of lesions and without requiring sedation. | Emanuele Tumino Rodolfo Sacco Marco Bertini Michele Bertoni Giuseppe Parisi Alfonso Capria | 2010 | World Journal of Gastroenterology2010，16，43： | 5 |
| 3 | Treatment of active steroid-refractory inflammatory bowel diseases with granulocytapheresis: Our experience with a prospective study显示文摘瞄准:与活跃的类固醇倔强的煽动性的肠疾病(IBD ) 在 14 个病人与 granulocytapheresis (GCAP ) 的使用报导我们的经验以便在完成宽恕并且维持一个长持续没有症状的时期评估它的功效。方法:疾病的活动被临床的活动索引(蔡) 和内视镜的索引(EI ) 在 ulcerative (UC ) 评估,当时由 Crohn 在 Crohn 的疾病(CD ) 的疾病活动索引(CDAI ) 。病人用 Adacolumn 系统被对待,有选择地绑在 granulocytes 和单核白血球的吸附列。GCAP 的一个会议 / 星期为 5 wk 被执行。类固醇在词首字母的脱落期间被停止。结果:所有病人完成了不显示出复杂并发症的五星期的功课。在最后会议的结束, 93% 病人显示出为 6 瞬间坚持了的疾病的临床的宽恕。在治疗的结束以后的九个月, 60% 案例维持了宽恕,当 23% 病人仍然在在 12 瞬间以后的临床的宽恕时。结论:就算我们有类固醇倔强的 IBD 的病人的数字不大,我们能断言 GCAP 很好被容忍并且有效特别在在治疗以后的开始的六个月内,在盒子的一个重要百分比。持续反应的率在 12 瞬间以后在 6 瞬间以后并且显著地稍微落下,然而,严重副作用的缺席能是为进一步评估治疗的新时间表的刺激。 | Bresci Giampaolo Parisi Giuseppe Bertoni Michele Mazzoni Alessandro Scatena Fabrizio Capria Alfonso | 2006 | World Journal of Gastroenterology2006，12，14： | 5 |
| 4 | The role of video capsule endoscopy for evaluating obscure gastrointestinal bleeding: usefulness of early use显示文摘 | Giampaolo Bresci Giuseppe Parisi Michele Bertoni Emanuele Tumino Alfonso Capria | 2005 | Journal of Gastroenterology2005，，3： | 2 |
| 5 | Percolation of single-walled carbon nanotubes in ceramic matrix nanocomposites显示文摘 | RUL S LEFEVRESCHLICK F CAPRIA E | 2004 | Acta Materialia2004，52，： | 1 |
| 6 | The role of video capsule endoscopy for evaluating obscure gastrointestinal bleeding: usefulness of early use显示文摘 | Giampaolo Bresci Giuseppe Parisi Michele Bertoni Emanuele Tumino Alfonso Capria | 2005 | Journal of Gastroenterology2005，，3： | 1 |
| 7 | Au- tomatic Target Recognition by means of Polarimetrie ISAR Images and Neural Networks 显示文摘 | Marco Martorlla Elisa Giusti Amerigo Capria | 2009 | IEEE Trans on Geosci- enee and Remote Sensing2009，47，11： | 1 |
| 8 | Prospective cy- tomegalovirus monitoring during first-line chemotherapy in patients with acute myeloid leukemia显示文摘 | Capria S Gentile G Capobianchi A | 2010 | J Med Virol2010，82，7： | 1 |
| 9 | Laser treatment of feeder vessels in subfoveal choroidal neovascular membrances: a revisitation using dynamic indocyanine green angiography显示文摘 | Staurenghi G Orzalesi N Capria AL | | 0，，： | 1 |
| 10 | Patent pooling: Uncorking a tech- nology transfer bottleneck and creating value in the biomedical research field 显示文摘 | Grassier F Capria M A | 2003 | Journal of Commercial Biotechnology2003，9，2： | 1 |
| 11 | Long-term anti-TNF-alpha treatments reverse the endothelial dysfunction in rheumatoid arthritis:the biological coherence between synovial and endothelial inflammation显示文摘 | Capria A De Nardo D Baffetti FR | 2010 | Int J Immunopathol Pharmacol2010，23，1： | 1 |
| 12 | How long can we give interleukin-2? Clinical and immunological evaluation of AML patients after 10 or more years of IL-2 administration显示文摘 | Meloni G Trisolini SM Capria S | | 0，，： | 1 |
| 13 | A new standardized electrochemical array for drug metabolic profiling with human cytochromes P450 显示文摘 | FANTUZZI A MAK L H CAPRIA E | 2011 | Anal Chem2011，83，10： | 1 |
| 14 | Duration of remission and long- term prognosis according to the extent of disease in patients with ul- cerative colitis on continuous mesalamine treatment 显示文摘 | Bresei G Parlsi G Capria A | 2008 | Colorectal dis2008，10，8： | 1 |
| 15 | Multidetector CT and virtual endoscopy in the evaluation of the esophagus显示文摘 | S. Mazzeo D. Caramella A. Gennai P. Giusti E. Neri L. Melai C. Cappelli R. Bertini A. Capria M. Rossi C. Bartolozzi | 2004 | Abdominal Imaging2004，，1： | 1 |
| 16 | Assessment of autonomic function in untreated adult coeliac disease显示文摘AIM: Some recent studies showed that alteration of upper-gut motility in coeliac disease may be related to dysfunction of autonomic nervous system. The aim of our study was to investigate whether autonomic nervous system was altered in untreated and unselected coeliac disease patients.METHODS: We studied 8 untreated and consecutive coeliac disease patients (2 males and 6 females, age range 37±14.5 years). Histological evaluation of duodenal mucosa, anti-gliadin antibodies (AGA), antiendomysial antibodies (EMA) and anti-tTG antibodies and sorbitol H2 breath test were performed in all patients. Extrinsic autonomic neuropathy was assessed by the standardized measurement of cardiovascular reflexes (lying-to-standing,Valsalva manoeuvre, deep breathing, sustained handgrip).The results obtained were compared with a healthy,asymptomatic control group (6 males and 7females, age range 42.3±13.5 years).RESULTS: Coeliac patients exhibited a lower increase of PAS as a response to isometric effort, a reduction of spectral power LF as a response to clinostatic position,but without statistical significance. Also they showed a lower tolerance to orthostatic position, associated with a latent disequilibrium of sympathetic-vagal balance, a relative prevalence of parasympathetic component of the autonomic function. However, these results were not statistically significant when compared with control group(P = n.s.). And they were unchanged after 6 and 12 mo of gluten-free diet.CONCLUSION: This study failed to confirm a significant correlation between autonomic dysfunction and coeliac disease, yet we could not exclude a role of autonomic dysfunction in the genesis of systemic symptoms in some coeliacs. | Gian Marco Giorgetti Antonio Tursi Cesare Iani Fiavio Areiprete Giovanni Brandimarte Ambrogio Capria Luigi Fontana | 2004 | World Journal of Gastroenterology2004，10，18： | 1 |
| 17 | Percolation of single-walled carbon nanotubes in ceramic matrix nanocomposites 显示文摘 | RUL S LEFEVRE-SCHL1CK F CAPRIA E LAURENT C PEIGNEY A | 2004 | Acta Materialia2004，52，： | 1 |
| 18 | Regulatory T cells in the immunodiagnosis and outcome of kidney allograft rejec- tion显示文摘 | FRANZESE O MASCALI A CAPRIA A | 2013 | Clin Dev Immunol2013，2013，85： | 1 |
| 19 | An electrochemical microfluidic platform for human P450 drug metabolism pro-filing显示文摘 | Fantuzzi A Capria E Mak L H | 2010 | Analytical Chemistry2010，82，10： | 1 |
| 20 | Dasatinib in the management of lymphoid blast crisis of Philadelphia-positive chronic myeloid leukemia with multiple extra-medullary and intracranial localizations显示文摘 | Giuliana Alimena Massimo Breccia Roberto Latagliata Sara Grammatico Angela Matturro Saveria Capria Maria Stefania De Propris Daniela Diverio Giovanna Meloni | 2009 | Leukemia Research2009，，8： | 1 |
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