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| 1 | Intraocular pressure elevation after intravitreal triamcinolone acetonide injection: a Meta-analysis显示文摘AIM:To report on intraocular pressure(IOP)after intravitreal injections of triamcinolone acetonide.·METHODS:Systematic literature review of studies that investigated the effects of an injection of triamcinolone Intravitreal triamcinolone acetonide on IOP was conducted according to the Cochrane Collaboration methodology and the reported effects have been analyzed with Meta-analysis.·RESULTS:We found that the IOP follows an inverted-U shape pattern over time starting with an average value of14.81±1.22 mm Hg before the injection,rising to a maximum of 19.48±2.15 mm Hg after one month of injection and falling down to 16.16±1.92 mm Hg after6mo.Moreover,country of study,age,previous history of glaucoma and gender compositions matter for crossstudy were different in reported IOP changes.·CONCLUSION:Our findings may be helpful in determining pressure elevation risk of intravitreal triamcinolone acetonide therapy as well as comparing it with those of more recent therapies such as the antivascular endothelial growth factor agents. | Cansu Yuksel-Elgin Ceyhun Elgin | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 6 |
| 2 | Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B显示文摘BACKGROUND Hepatitis B virus is a universal health problem.There are approximately 250 million people living with hepatitis B worldwide,and approximately 600000 of these people die every year due to the virus.AIM To compare the pretreatment and post-treatment histopathological results of patients with hepatitis be antigen(HBeAg)-negative chronic hepatitis B(CHB)who had been receiving tenofovir disoproxil fumarate(TDF)treatment at our clinic for at least 5 years.METHODS Patients with HBeAg-negative CHB who were being treated with TDF(245 mg/d)were included in the study.Liver biopsies of patients before TDF treatment and liver biopsies after 5 years of TDF treatment were retrospectively compared.RESULTS A total of 50 HBeAg-negative CHB patients were included in the study(mean age:47.9±10.4 years,men:27.54%).Histological improvement was observed in 78%(39)of the patients after 5 years of treatment.After the 5 years of treatment,the mean Ishak score of the patients was 1.3±1.3,and the mean histologic activity index score was 4.1±2.8.A 1.53 point reduction in Ishak fibrosis score was detected after long-term TDF treatment.CONCLUSION Liver biopsies after 5 years of TDF treatment revealed a significant histological response and a regression of the necroinflammatory score compared to pretreatment liver biopsies.To better understand the effects of antiviral treatments on the improvement of liver histology,long-term studies involving larger numbers of patients are needed. | Bahri Abayli Cansu Abaylı Genco Gencdal | 2021 | World Journal of Gastrointestinal Pharmacology and Therapeutics2021，12，2： | 4 |
| 3 | Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characteriza tion of breast tumors显示文摘 | Kul S Cansu A Alhan E | 2011 | Am J Roentgenology2011，196，1： | 1 |
| 4 | The effectsof oxcarbazepine and valproate therapies on growth in childrenwith epilepsy 显示文摘 | CANSU A’YESILKAYA E SERDAROGLU A | 2012 | Endocrine research2012，37，4： | 1 |
| 5 | Strong purifying selection in transmission of mammalian mitochondrial DNA显示文摘 | Stewart JB Freyer C Elson JL Wredenberg A Cansu Z Triftmovie A Larsson NG 2008 | 2008 | PLoS Biol2008，6，： | 1 |
| 6 | Prevalence of some risk factors in children with epilepsy compared to their controls 显示文摘 | Cansu A Serdaroqlu A Yuksel D | 2007 | Seizure2007，16，4： | 1 |
| 7 | The evaluation of thyroid functions, thyroid antibodies, and thyroid volumes in children with epilepsy during short - term administration of oxcarbazepine and valpmate显示文摘 | Cansu A Serdaroglu A Camurdan O | 2006 | Epilepsia2006，47，11： | 1 |
| 8 | Myocardial infarction in young pa- tients ( < or = 35 years of age) with systemic lupus erythematosus : a case report and clinical analysis of the literature 显示文摘 | Korkmaz C Cansu DU Kasifoglu T | 2007 | Lupus2007，16，4： | 1 |
| 9 | Effects of Stevia rebaudiana ( Bertoni) extract and N- nitro-L-arginine on renal function and ultrastructure of kidney cells in experimental type 2 Diabetes 显示文摘 | Ozbayer Cansu Kurt Hulyam Kalender Suna | 2011 | J Med Food2011，14，10： | 1 |
| 10 | Effects of chronic treatment with valpmate and oxcarbazepine on testicular development in rats 显示文摘 | Cansu A Ekinci 0 Serdaroglu A | 2011 | Seizure2011，20，3： | 1 |
| 11 | Contribution of Diffusion Weighted Imaging to Dynamic Contrast-Enhanced MRI in the Characterization of Breast Tumors 显示文摘 | Kul S Cansu A Alhan E | 2011 | AJR2011，196，1： | 1 |
| 12 | Contribution of diffusion-weigh- ted imaging to dynamic contrast-enhanced MRI in the character- iation of breast tumors显示文摘 | Kul S Cansu A Alhan E | 2011 | AJR2011，196，1： | 1 |
| 13 | Myocardial infarction in young patients (35 years of age) with systemic lupus erythematosus : a case report and clinical analysis of the literature 显示文摘 | Korkmaz C Cansu DU Ka:ifo:tu T | 2007 | Lupus2007，16，： | 1 |
| 14 | Contrast-enhanced MR angiog- raphy of the breast evaluation of ipsilateral increased vascularity and adjacent vessel sign in the characterization of breast lesions 显示文摘 | Kul S Cansu A Alhan E | 2010 | AJR2010，195，5： | 1 |
| 15 | Hyperglyeaemia in acute ischaemic stroke is associated with an increased 5-year mortality 显示文摘 | KOSTULAS N MARKAKI I CANSU H | 2009 | Age Ageing2009，38，5： | 1 |
| 16 | Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate 显示文摘 | Cansu A Serdaroglu A Camurdan O | 2011 | Horm Res Paediatr2011，76，1： | 1 |
| 17 | Contribution of MRI toultrasound in the diagnosis of fetal anomalies显示文摘 | Kul S Korkmaz HA Cansu A | 2012 | J Magn ResonImaging2012，35，： | 1 |
| 18 | 含季铵盐的芳酰腙配体的铜(Ⅱ)配合物的合成和表征:体外DNA键合和核酸酶活性显示文摘制备了2个新的含有N,N,N-三甲基丙烷-1-铵基团和N,N,N-三甲基戊烷-1-铵基团的苯乙酮-(4-羟基苯腙)配体:(E)-3-(4-(1-(2-(4-hydroxybenzoyl)hydrazono)ethyl)phenoxy)-N,N,N-trimethylpropan-1-ammonium perchlorate(H2L1)和(E)-3-(4-(1-(2-(4-hy-droxybenzoyl)hydrazono)ethyl)phenoxy)-N,N,N-trimethylpentane-1-ammonium perchlorate(H2L2)。以这2个配体分别合成了2个新的铜配合物:[Cu(HL1)2]和[Cu(HL2)2],研究了这些配体和配合物的DNA结合和切割活性,还研究了DNA切割的机理以及化合物浓度对DNA切割反应的影响。紫外-可见光谱结果表明,所有化合物均优先通过主沟结合模式与DNA结合,在甲基绿(主要的沟结合剂)的存在下切割DNA的活性受到抑制的结果也支持这一结论。电泳研究的结果则表明,化合物在存在或不存在氧化剂(H2O2)的情况下均对质粒DNA表现出显著的切割活性,活性主要取决于化合物的浓度。化合物通过水解途径裂解pBR322 DNA,在存在不同自由基清除剂情况下的DNA裂解实验也支持这一结论。 | EdaŞengül Elif Cansu Gökçe Topkaya Tolga Göktürk Ramazan Gup | 2020 | 无机化学学报2020，36，7： | 1 |
| 19 | Effects of subtoxic concentrations of TiO2 and ZnO nanoparticlcs on human lymphocytes,dendritic cells and exosomc productio 显示文摘 | Andersson-Willman B G-chrmarm U Cansu Z | 2012 | Toxicol Appl Phannacol2012，264，1： | 1 |
| 20 | Duplication of the inferior vena cava with azygos continuation,retroaortic left renal vein and iliac vein variations显示文摘 | Ahmetoglu A Cansu A | | 0，，07： | 1 |
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