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| 1 | The secretion profile of mesenchymal stem cells and potential applications in treating human diseases显示文摘Mesenchymal stromal/stem cells(MSCs)possess multi-lineage differentiation and self-renewal potentials.MSCs-based therapies have been widely utilized for the treatment of diverse inflammatory diseases,due to the potent immunoregulatory functions of MSCs.An increasing body of evidence indicates that MSCs exert their therapeutic effects largely through their paracrine actions.Growth factors,cytokines,chemokines,extracellular matrix components,and metabolic products were all found to be functional molecules of MSCs in various therapeutic paradigms.These secretory factors contribute to immune modulation,tissue remodeling,and cellular homeostasis during regeneration.In this review,we summarize and discuss recent advances in our understanding of the secretory behavior of MSCs and the intracellular communication that accounts for their potential in treating human diseases. | Yuyi Han Jianxin Yang Jiankai Fang Yipeng Zhou Eleonora Candi Jihong Wang Dong Hua Changshun Shao Yufang Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 6 |
| 2 | T辅助细胞在疫苗研制中的作用(英文)显示文摘发展感染性疾病疫苗之关键挑战在于利用确定的抗原以刺激产生能引起保护作用的合适的免疫反应。肽类疫苗的运用得到了极大的关注 ,其意义在于 ,已知不同的多表位构成单一结构以诱导出所希望的免疫反应所表现出的灵活性。这一般比利用减毒的活疫苗要安全并且相对而言比制造亚单位疫苗要容易。然而 ,多肽疫苗的发展面临巨大挑战。这一方法在诱导遗传背景复杂的人群免疫反应方面受到限制 ,这与主要组织相溶性复合物 (MHC)多态性有关。因同样的理由 ,肽类免疫应答常因缺乏适当的辅助T淋巴细胞 (HTL)而引导出不充分的细胞毒素T淋巴细胞 (CTL)和抗体反应。另一个运用线性肽链结构的可能缺点是 :为了引导出合适抗体反应 ,表面免疫球蛋白受体簇对于激活静息的B细胞就成为必须因素。由MHC多肽性引起的问题可由运用不加区别的T细胞表位来解决。从麻疹病毒F蛋白 (氨基酸 2 88到 30 2 )中得到的不加区别的T细胞表位和鼠的确定结合在多种MHC分子上的辅助T细胞表位 (V1EB ,aa 191- 2 0 9)已被定性并且被用于能极大激发免疫应答的结构中 ,以克服单一限制型免疫应答的缺陷。合成的 ,非自然PanDR表位 (PADRE)具有退化的结合几种通常HLA DR的能力 ,能以绝对效价和抗体反应质量两种形式来增强激发短肽链的免疫应答。另外 ,? | Waiyan Candy Ng 冯明钊 | 2002 | 热带医学杂志2002，2，3： | 2 |
| 3 | Insights into the Microwave Instruments Onboard the Fengyun 3D Satellite:Data Quality and Assimilation in the Met Office NWP System显示文摘This paper evaluates the microwave instruments onboard the latest Chinese polar-orbiting satellite, Fengyun 3D (FY- 3D). Comparing three months of observations from the Microwave Temperature Sounder 2 (MWTS-2), the Microwave Humidity Sounder 2 (MWHS-2), and the Microwave Radiation Imager (MWRI) to Met Office short-range forecasts, we characterize the instrumental biases, show how those biases have changed with respect to their predecessors onboard FY- 3C, and how they compare to the Advanced Technology Microwave Sounder (ATMS) onboard NOAA-20 and the Global Precipitation Measurement Microwave Imager (GMI). The MWTS-2 global bias is much reduced with respect to its predecessor and compares well to ATMS at equivalent channel frequencies, differing only by 0.36 ± 0.28 K (1σ) on average. A suboptimal averaging of raw digital counts is found to cause an increase in striping noise and an ascending- descending bias. MWHS-2 benefits from a new calibration method improving the 183-GHz humidity channels with respect to its predecessor and biases for these channels are within ± 1.9 K to ATMS. MWRI presents the largest improvements, with reduced global bias and standard deviation with respect to FY-3C;although, spurious, seemingly transient, brightness temperatures have been detected in the observations at 36.5 GHz (vertical polarization). The strong solar-dependent bias that affects the instrument on FY-3C has been reduced to less than 0.2 K on average for FY-3D MWRI. Experiments where radiances from these instruments were assimilated on top of a full global system demonstrated a neutral to positive impact on the forecasts, as well as on the fit to the background of independent instruments. | Fabien CARMINATI Nigel ATKINSON Brett CANDY Qifeng LU | 2021 | Advances in Atmospheric Sciences2021，38，8： | 2 |
| 4 | 阿尔茨海默病的血液生物标志物:一项基于中国多中心的横断面和纵向研究显示文摘阿尔茨海默病(AD)的生物标志物在血液中含量可能因种族、老年性疾病与各种环境风险因素等不同而存在差异,尚缺乏系统性的研究来评估AD生物标志物在中国老年及AD患者人群中的变化以及是否具有准确预测脑内淀粉样蛋白沉积的能力.本工作为一项多中心纵向队列研究,共纳入来自全国各地6个不同临床中心的817个血液样本.研究测量了多个国际上通用的AD生物标志物,包括β-淀粉样蛋白40与42、磷酸化Tau(pTau)蛋白、总Tau蛋白、神经纤维丝轻链(NFL)和胶质纤维酸性蛋白(GFAP),并使用淀粉样斑块PET示踪剂和核磁结构影像对受试者进行综合评估.研究发现,APOE基因型与血浆pTau或血清GFAP组合的预测模型对脑内淀粉样斑块的沉积状态具有较好的区分能力.此外,研究还发现GFAP基线水平越高的患者其神经退行性变的速度越快.本研究结果基于多中心数据,论证了AD血液生物标志物在中国汉族人群中的实用性和应用前景,提示了血液pTau和GFAP是检测AD早期症状的有效指标,为我国AD的早期诊断和治疗提供了参考. | 高峰 戴林斌 王琼 刘畅 邓克学 程昭昭 吕心怡 吴燕 张子伊 陶青青 袁晶 李世平 王越 苏娅 程忻 倪俊 吴志英 张舒婷 施炯 申勇 China Aging and Neurodegenerative Initiative(CANDI)Consortium | 2023 | Science Bulletin2023，68，16： | 2 |
| 5 | Copper binding to the N-terminal tandem repeat regions of mammalian and avian PrP protein显示文摘 | HOMSHAW M P MCDERMOTT J R CANDY J M | 1995 | Biochem Biophys Res Commun1995，207，2： | 1 |
| 6 | Near optimal signal recovery from ran- dom projections 显示文摘 | CANDI~S E TAO T | 2006 | IEEE Transactions on Information The- ory2006，52，12： | 1 |
| 7 | Model-based signal enhancement for the Hudson Canyon experiment显示文摘 | Candy J V Sullivan E J | 1994 | Journal of Computational Acoustics1994，2，3： | 1 |
| 8 | Decoding by linear programming显示文摘 | CANDIS E TAO T | 2005 | IEEE Transaction on Infiwmation TheoF2005，51，12： | 1 |
| 9 | TAp63 and delta Np63in cancer and epidermal development显示文摘 | Candi E Dinsdale D Rufini A | 2007 | Cell Cycle2007，6，3： | 1 |
| 10 | 美国ANSI/AISC SSPEC-2002《钢结构建筑抗震设计规定》介绍显示文摘 | Candy | 2006 | 广告大观(标识版)2006，，11： | 1 |
| 11 | Antihypertensive effect of low dose hydrochlorothiazide alone or in combination with quinapril in black patients with mild to moderate hypertension显示文摘 | Radevski IV Valtchanova ZP Candy GP | 2000 | J Clin Pharmacol2000，40，： | 1 |
| 12 | Angiotensinogen g-ene promoter region variant modifies body size-ambulatory blood pressure relations in hypertension显示文摘 | TIAGO A D SAMANI N J CANDY G P | 2002 | Circulation2002，106，12： | 1 |
| 13 | Molecuar characterization ofa carboxy-terminal cell-binding dimain of intimin from enteropathogeicEscherichia coli 显示文摘 | Frankel G Candy D C A Fabiani E | 1995 | Infection and Immunity1995，63，： | 1 |
| 14 | Robust uncertainty principles: exact signal reconstruction from highly incomplete frequency informa- tion显示文摘 | CANDIS E J ROMBERG J TAO T | 2006 | IEEE Trans on Information Theory2006，52，2： | 1 |
| 15 | The β-mannanases elaborated by the phytopathogen Xanthomonas campestris显示文摘 | Robert F. H. Dekker Geoffrey P. Candy | 1979 | Archives of Microbiology1979，，3： | 1 |
| 16 | The corni- fled envelope:a model of cell death in the skin 显示文摘 | Candi E Schmidt R Melino G | 2005 | Nature Reviews Molecular Cell Bidogy2005，6，4： | 1 |
| 17 | Decimation for sigma delta modulation显示文摘 | Candy J C | 1986 | IEEE Trans Commun1986，34，1： | 1 |
| 18 | Follicular development in cryopreserved marmoset ovarian tissue after transplantation显示文摘 | Candy CJ Wood MJ Whittingham DG | 1995 | Hum Reprod1995，10，9： | 1 |
| 19 | Spinal tuberculosis:magnetic resonance imaging and neurological impairment显示文摘 | Punn E Zondagh I Candy S | 2011 | Spine(Phila Pa ]976)2011，56，6： | 1 |
| 20 | The addition of pentoxifylline to conventional therapy improves outcome in patients with peripartum cardiomyopathy显示文摘 | Sliwa K Skudicky D Candy G | 2002 | Eur J Heart Fail2002，4，3： | 1 |
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