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| 1 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 2 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 3 | MiR-138 and MiR-135 Directly Target Focal Adhesion Kinase, Inhibit Cell Invasion, and Increase Sensitivity to Chemotherapy in Cancer Cells显示文摘 | Vita M. Golubovskaya Brittany Sumbler Baotran Ho Michael Yemma William G. Cance | 2014 | Anti-Cancer Agents in Medicinal Chemistry2014，，1： | 2 |
| 4 | Association between calcium ingested from drinking water and femoral bone density in elderly women : evidence from the EPIDOS cohort 显示文摘 | Aptel I Cance RA Grandjean H | 1999 | J Bone Miner Res1999，14，5： | 1 |
| 5 | Culture of human epithelium显示文摘 | De luca M Canc edda R | 1992 | Burns1992，18，1： | 1 |
| 6 | A new integral equation formalism for the polarizable continuum model: Theoretical back ground and ap- plications to i, wtropic and anisotropic dielectrics显示文摘 | Cances M T Mennucci V Tomaso J | 1997 | Journal of Chemical Physics1997，107，8： | 1 |
| 7 | Bone density changes after radiation for extremity sarcomas:exploring the etiology of pathologic fractures显示文摘 | Dhakal S Chen J Mc Cance S | 2011 | Int J Radiat Oncol Biol Phys2011，80，4： | 1 |
| 8 | The effect of finite periods of undernutrition at different ages on the composition and subsequent development of the rat显示文摘 | Widdowson EM Mc Cance RA | 1963 | Proc R Soc Lond B Biol Sci1963，158，： | 1 |
| 9 | Focal adhesion kinase and cancer显示文摘 | Golubovskaya VM Kweh FA Cance WG | 2009 | Histol Histopathol2009，24，4： | 1 |
| 10 | Front - line transplantation program with lenalidomide, bortezomib, and dexam- ethasone combination as induction and consolidation followed by lenalidomide maintenance in patients with multiple myeloma: A phase Ⅱ study by the intergroupe francophone du my~lome 显示文摘 | Roussel M Lauwers Cances V Robillard N | 2014 | J Clin Onco12014，32，25： | 1 |
| 11 | Long-term outcome of neoadjuvant therapy for locally advanced breast carcinoma: effective clinical downstaging allows breast preservating and predicts outstanding local control and survival 显示文摘 | Cance WG Carey LA Calvo BF | 2002 | Ann Surg2002，236，3： | 1 |
| 12 | Inproved screen-ing for peanut allengy by the combined use of skin pricktests and specific IgE assays显示文摘 | Ranee F Abbal M Lauwers Cances V | 2002 | J Allergy Clin Inmunol2002，109，： | 1 |
| 13 | Focal adhesion kinase and cancer显示文摘 | Golubovskaya V M Kweh F A Cance W G | 2009 | Histol Histopathol2009，24，： | 1 |
| 14 | Association between calcium ingested from drinking water and femoral bone density in elderly women: evidence from the EPIDOS cohort显示文摘 | Aptel I Cance R A Grandjean H | 1999 | Journal of Bone and Mineral Research1999，14，5： | 1 |
| 15 | Focal Adhesion Kinase and p53 signal transduction pathways in cancer显示文摘 | Golubovskaya VM Cance W | 2010 | Front Bio- sci2010，，15： | 1 |
| 16 | 显示文摘 | CANCES E MENNUCCI B TOMASI J | 1997 | J Chem Phys1997，107，： | 1 |
| 17 | Long-term outcome of neoadjuvant therapy for locally advanced breast carcinoma effective clinical downstaging allows breast preservation and predicts outstanding local control and survival显示文摘 | William G Cance MD Lisa A | 2002 | Ann Surg2002，236，3： | 1 |
| 18 | Unhealthy weight control behaviors and MDMA (ecstasy) use among adolescent females显示文摘 | Cance JD Ashley OS Penne MA | 2005 | J Adolesc Health2005，37，： | 1 |
| 19 | Insulinoma:pitfalls in preoperative localization 显示文摘 | Owens L V Huth L F Cance WG | 1995 | Eur J Surg Oncol1995，21，3： | 1 |
| 20 | Birth Weight and non-insulin dependent: thrifty genotype, thrifty phenotype, or surviving Small baby genotype 显示文摘 | Mc Cance DR Pettitt DJ Hanson RL | 1994 | BMJ1994，308，6934： | 1 |
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