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| 1 | miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. | Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey | 2011 | World Journal of Gastroenterology2011，17，8： | 13 |
| 2 | DNA-informed breeding of rosaceous crops: promises, progress and prospects显示文摘Crops of the Rosaceae family provide valuable contributions to rural economies and human health and enjoyment.Sustained solutions to production challenges and market demands can be met with genetically improved new cultivars.Traditional rosaceous crop breeding is expensive and time-consuming and would benefit from improvements in efficiency and accuracy.Use of DNA information is becoming conventional in rosaceous crop breeding,contributing to many decisions and operations,but only after past decades of solved challenges and generation of sufficient resources.Successes in deployment of DNA-based knowledge and tools have arisen when the‘chasm’between genomics discoveries and practical application is bridged systematically.Key steps are establishing breeder desire for use of DNA information,adapting tools to local breeding utility,identifying efficient application schemes,accessing effective services in DNA-based diagnostics and gaining experience in integrating DNA information into breeding operations and decisions.DNA-informed germplasm characterization for revealing identity and relatedness has benefitted many programs and provides a compelling entry point to reaping benefits of genomics research.DNA-informed germplasm evaluation for predicting trait performance has enabled effective reallocation of breeding resources when applied in pioneering programs.DNA-based diagnostics is now expanding from specific loci to genome-wide considerations.Realizing the full potential of this expansion will require improved accuracy of predictions,multi-trait DNA profiling capabilities,streamlined breeding information management systems,strategies that overcome plant-based features that limit breeding progress and widespread training of current and future breeding personnel and allied scientists. | Cameron P Peace | 2017 | Horticulture Research2017，4，1： | 11 |
| 3 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 4 | Vitamin D receptor expression in human bone tissue and dose-dependent activation in resorbing osteoclasts显示文摘The effects of vitamin D on osteoblast mineralization are well documented. Reports of the effects of vitamin D on osteoclasts, however, are conflicting, showing both inhibition and stimulation. Finding that resorbing osteoclasts in human bone express vitamin D receptor(VDR), we examined their response to different concentrations of 25-hydroxy vitamin D_3[25(OH)D_3](100 or 500 nmol·L^(-1)) and 1,25-dihydroxy vitamin D_3[1,25(OH)_2D_3](0.1 or 0.5 nmol·L^(-1)) metabolites in cell cultures. Specifically, CD14+ monocytes were cultured in charcoal-stripped serum in the presence of receptor activator of nuclear factor kappa-B ligand(RANKL) and macrophage colony-stimulating factor(M-CSF). Tartrate-resistant acid phosphatase(TRAP)histochemical staining assays and dentine resorption analysis were used to identify the size and number of osteoclast cells, number of nuclei per cell and resorption activity. The expression of VDR was detected in human bone tissue(ex vivo) by immunohistochemistry and in vitro cell cultures by western blotting.Quantitative reverse transcription-PCR(q RT-PCR) was used to determine the level of expression of vitamin D-related genes in response to vitamin D metabolites. VDR-related genes during osteoclastogenesis, shown by q RT-PCR, was stimulated in response to 500 nmol·L^(-1)of 25(OH)D_3and 0.1–0.5 nmol·L^(-1)of 1,25(OH)_2D_3,upregulating cytochrome P450 family 27 subfamily B member 1(CYP27B1) and cytochrome P450 family 24 subfamily A member 1(CYP24A1). Osteoclast fusion transcripts transmembrane 7 subfamily member 4(tm7sf4) and nuclear factor of activated T-cell cytoplasmic 1(nfatc1) where downregulated in response to vitamin D metabolites. Osteoclast number and resorption activity were also increased. Both 25(OH)D_3and1,25(OH)_2D_3reduced osteoclast size and number when co-treated with RANKL and M-CSF. The evidence for VDR expression in resorbing osteoclasts in vivo and low-dose effects of 1,25(OH)_2D_3on osteoclasts in vitro may therefore provide insight into the effects of clinical vitamin D treatments, further providing a counterpoint to the high-dose effects reported from in vitro experiments. | Allahdad Zarei Alireza Morovat Kassim Javaid Cameron P Brown | 2016 | Bone Research2016，4，3： | 5 |
| 5 | Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms显示文摘AIM To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction(ACPO).METHODS A systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken. RESULTS No consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors. CONCLUSION Future research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment. | Cameron I Wells Gregory O’Grady Ian P Bissett | 2017 | World Journal of Gastroenterology2017，23，30： | 2 |
| 6 | Rib fractures in major trauma显示文摘 | Dziukas L Hadj A | 1996 | Aust N Z J Surg1996，66，： | 1 |
| 7 | Influence of organic phosphonates on hydroxyapatite crystallite growth kinetics 显示文摘 | Zieba A G Sethnraman F P Nancollas G H Cameron D | 1996 | Langmuir1996，12，11： | 1 |
| 8 | Recovery of retrograde condensed liquids by re-vaporization during dry gas injection显示文摘 | Sigmund P M Cameron A M | 1977 | JCPT1977，16，1： | 1 |
| 9 | Internationalcomparison of prehospital trauma care systems显示文摘 | Roudsari BS Nathens AB Cameron P | 2007 | Injury2007，38，9： | 1 |
| 10 | A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase显示文摘 | Hong Z Cameron C E Walker M P | 2001 | Virology2001，285，： | 1 |
| 11 | Improving 1,3-propanediol production from glycerol in a metabolically engineered Escherichia coli by reducing accumulation of sn-Glycerol-3-phosphate显示文摘 | Zhu M M Lawmnan P D Cameron D C | 2002 | Biotechnol Prog2002，18，4： | 1 |
| 12 | Hymenoptera Orientalis; or contributions to a knowledge of the Hymenoptera of the Oriental Zoological Region显示文摘 | Cameron P | | Memoirs and Proceedings of the Manchester Literary & Philosophical Society (Series 4)0，2，： | 1 |
| 13 | Aliphatic polyester polymer stars:synthesis,properties and applications in biomedicine and nanotechnology显示文摘 | Cameron D J A Shaver M P | 2011 | Chemical Society Reviews2011，40，3： | 1 |
| 14 | On the balancing of structural and acoustic performance of a sandwich panel based on topology, property, and size optimization显示文摘 | Cameron C J Lind Nordgren E Wennhage P | 2014 | Journal of Sound and Vibration2014，333，13： | 1 |
| 15 | Bladder management after spinal cord injury in the United States 1972 to 2005 显示文摘 | Cameron A P Wallner L P Tare D G | 2010 | J Urol2010，184，1： | 1 |
| 16 | Better sintering through green--state deformation processing显示文摘 | CAMERON C P RAJ R | 1990 | J Am Ceram Soc1990，70，2： | 1 |
| 17 | Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway显示文摘 | Cameron HA Tanapat P Gould E | 1998 | Neuroscience1998，82，2： | 1 |
| 18 | Diagnosis and management of spontaneoustramsmural rapture of the esophagus显示文摘 | WALKER W S CAMERON E W J WALBAUM P R | 1985 | Br J surg1985，72，： | 1 |
| 19 | Seasonal atrophy of the visceral organs in sea cucumber显示文摘 | FRANKBONER P V CAMERON J L | 1985 | Can J Zool1985，63，12： | 1 |
| 20 | Mutagenic activity of 27 dyes and related chemicals in the Salmonella/microsome and mouse lymphoma TK^+/- assays显示文摘 | Cameron T P Hughes T J Kirby P E | 1987 | Mutat Res1987，，189： | 1 |
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