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| 1 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 2 | Kinetics and hydrolysis mechanism of chlorsulfuron and metsulfuron-methyl显示文摘 | Hemmamda S M Calmon J P | 1994 | Pesticide Science1994，40，： | 1 |
| 3 | Kinetics and hydrolysis mechanism of chlorsulfuron dnd metsulfuron-methyl 显示文摘 | HEMMADA S CALMON M CALMON P | 1994 | Pestic Sci1994，，40： | 1 |
| 4 | Mechanisms of dicarboximide ring opening in aqueous media:procymidone,vinclozolin and chlozolinate显示文摘 | Villedieu JC Calmon M Calmon JP | 1994 | Pestic Sci1994，41，2： | 1 |
| 5 | Kinetics and hydrolysis mechanism of chlorsulfuron and metsulfuron- methyl显示文摘 | Hemmamda S Calmon M Calmon JP | 1994 | Weed Sci1994，40，： | 1 |
| 6 | An integrated model to simulate the scattering of ultrasounds by inclusions in steels显示文摘 | DARMON M CALMON P BELE B | 2004 | Ultrasonics2004，42，19： | 1 |
| 7 | Kinectics and hydrolysis mechanism off chlorsulfuron and metsulfuronmethyl显示文摘 | Hemmamda S Calmon M Calmon J P | 1994 | Pesticide Science1994，40，1： | 1 |
| 8 | Penile carcinoma:Risk factors and molecular alterations显示文摘 | Calmon M F Tasso M M Vassallo J | 2011 | ScientificWorld Journal2011，11，： | 1 |
| 9 | Mechanisms of dicarboximide ring opening in aqueous media : procymidone, vinclozolin and chlozolinate 显示文摘 | Villedieu J C M Calmon and J P Calmon | 1994 | Pestic Sci1994，41，： | 1 |
| 10 | An Integrated Model to Simulate the Scattering of Ultrasounds by Inclusions in Steels显示文摘 | Darmon M Calmon P Bele B | 2004 | Ultrasonics2004，42，： | 1 |
| 11 | Kinectics and hydrolysis mechanism off chlorsulfuron and metsulfuron methyl显示文摘 | Hemmanda S Calmon M Calmon J P | 1994 | Pestic Sci1994，40，： | 1 |
| 12 | MRCS-selecting maximal ratio com- bined signals:a practical hybrid diversity combing scheme显示文摘 | Calmon F P Yacoub M D | 2009 | IEEE Communications Transactions on Wireless Communi- cations2009，8，： | 1 |
| 13 | Kinectics and hydrolysis mechanism of chlorsulfuron and metsulfuron-methyl显示文摘 | HEMMANDA S CALMON M CALMON J P | 1994 | Pesticide Science1994，40，： | 1 |
| 14 | An integrated model to simulate the scatterirlg of ultra- sounds by inclusions in steels 显示文摘 | DARMON M CALMON P BERTRAND B | 2004 | Ultrasonics2004，42，19： | 1 |
| 15 | Kinetics and hydrolysis mechanism of chlorsulfuron and metsulfuron-methyl显示文摘 | Hemmamda S Calmon M Calmon J P | 1994 | Weed Sci1994，40，： | 1 |
| 16 | An integrated model to simulate the scattering of ultrasounds by inclusions in steels显示文摘 | DARMON M CALMON P BELE B | 2004 | Ultrasonics2004，42，： | 1 |
| 17 | FPGA and mixed FPGA-DSP implementations Of electrical drive algorithms显示文摘 | Calmon F Fathallah M Viverge P J | 2002 | Lecture Notes in Computer Science2002，4，2： | 1 |
| 18 | Methylation profile of genes CDKN2A (P14 and P16),DAPK1,CDH1,and ADAM23 in head and neck cancer显示文摘 | Calmon M F Colombo J Carvalho F | 2007 | Cancer Genet Cytogenet2007，173，1： | 1 |
| 19 | An integrated model to simulate the scattering of ultrasounds by inclusions in steels显示文摘 | DARMON M CALMON P BELE B | 2004 | Ultrasonics2004，42，19： | 1 |
| 20 | Kinetics and hydrolysis mechanism of chlorsulfuron and metsulfuron- methyl 显示文摘 | Hernmamda S Calmon M Calmon J P | 1994 | Pesti Sci1994，40，： | 1 |
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