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337篇 您的检索式：作者名="Callaghan C"

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	题名	作者	年代	出处	被引量
1	BRAF inhibitor treatment of melanoma causing colonic polyps:An alternative hypothesis显示文摘Colonic polyps may arise from BRAF inhibitor treatment of melanoma, possibly due paradoxical activation of the mitogen-activated protein(MAP)-kinase pathway. In an alternative evidence based scenario, tubular colonic adenomas with APC gene mutations have also been identified in the context of BRAF inhibitor treatment, in the absence of mutations of MAPK genes. A minority of colorectal cancers develop by an alternative 'serrated polyp pathway'. This article postulates a novel hypothesis, that the established phenotypic and molecular characteristics of serrated colonic polyps/CRC offer an intriguing insight into the pathobiology of BRAF inhibitor induced colonic polyps. Serrated polyps are characterized by a Cp G island methylation phenotype, MLH1 silencing and cellular senescence. They also have BRAF mutations. The contention is that BRAF inhibitor induced polyps mimic the afore-described histology and molecular features of serrated polyps with the exception that instead of the presence of BRAF mutations they induce C-RAF homodimers and B-RAF: C-RAF heterodimers.	Fergal C Kelleher Grainne Callaghan Catriona Gallagher Hazel O'Sullivan	2017	World Journal of Gastroenterology2017，23，17：	2
2	Application of fragment screening by X-ray crystallography to β-secretase 显示文摘	MURRAY C W CALLAGHAN O CHESSARI G	2007	J Med Chem2007，50，6：	1
3	Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy显示文摘	Walker J Martin C Callaghan R	2002	Euro J Cancer2002，40，4：	1
4	Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis显示文摘	Joinson C O'Callaghan FJ Osborne JP	2003	Psychol Med2003，32，2：	1
5	Therapeutic concentra- tions of valproate but not a mitriptyline increase neuropeptide Y(NPY) expression in the human SH - SY5Y neuroblastoma cell line 显示文摘	Farrelly LA Savage NT O'Callaghan C	2013	Regul Pept2013，186，：	1
6	A serological survey of ruminant livestock in Kazakhstan during post-Soviet transitions in farming and disease control显示文摘	LUNDERVOLD M MILNER GULLAND E J O' CALLAGHAN C J	2004	Acta Vet Scand2004，45，34：	1
7	Increased circulating levels of matrix metaUoproteinase-2 and -9 in women with the polycystic ovary syndrome显示文摘	Lewandowski K C Komorowski J O'Callaghan C J	2006	J Clin Endocrinol Metab2006，91，3：	1
8	Quantum dot nanoparticies affect the reproductive system of Caenorhabditis elegans显示文摘	Hsu P C O'Callaghan M Al- Salim N	2012	Environmental Toxicology and Chemistry2012，31，10：	1
9	Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy显示文摘	Walker J Martin C Callaghan R	2004	Eur J Cancer2004，40，4：	1
10	BirA En- zyme: Production and Application in the Study of Mem- brane Receptor - Ligand Interactions by Site-Specific Biotinylation Original Research 显示文摘	O'Callaghan C A Byford M F Wyer J R Willcox BE Jakobsen B K McMichael A J Bell J 1	1999	Anal Biochem1999，266，1：	1
11	The evolution of clinical significance显示文摘	William C Follette Glenn M Callaghan	2001	Clinical psycholology:Science and Practice2001，8，4：	1
12	Differences in soil enzyme activities, microbial community structure and short term nitrogen mineralization resulting from farm management history and organic matter amendments显示文摘	Stark C H Condron L M O' Callaghan M	2008	Soil Biol Biochem2008，40，：	1
13	Hyperglycemia-induced reactive oxygen species and impaired endothelial progenitor cell function显示文摘	Callaghan M J Ceradini D J Gunner G C	2005	Antioxid Redox Signal2005，7，1112：	1
14	Nebulization of corticosteroids to asthmatic children:Large variation in dose inhaled显示文摘	O'Callaghan C White J A Kantar A	2014	Respirology2014，19，2：	1
15	Interactions of rhizobia with rice and wheat显示文摘	Webster G Gough C Vasse J Batchelor C A O' Callaghan K J Kothari S L Davey M R Denarie G Cocking E C	1997	Plant and Soil1997，194，12：	1
16	Music Therapy as a Non-pharmacological Anxiolytic for Paediatric Radiotherapy Patients显示文摘	O'Callaghan C Sexton M Wheeler G	2007	Australas Radiol2007，51，2：	1
17	Biogeochemistry of microbial coal-bed methane 显示文摘	Str?po? D Mastalerz M Dawson K Macalady J Callaghan AV Wawrik B Turich C Ashby M	2011	Annu Rev Earth Planet Sci2011，39，：	1
18	Rational combinations of trasruzumab with chemotherapeutic drugs used in the treatment of breast cancer 显示文摘	Pegram MD Konecny GE O'Callaghan C	2004	J Natl Cancer Inst2004，96，10：	1
19	The role of pneumococcal pneumonia and meningitis 显示文摘	Hirst RA Kadioglu A O'callaghan C	2004	Clin Exp Immunol2004，138，2：	1
20	A comparison of on-line techniques for determination of curd setting time using cheesemilks under different rates of coagulation 显示文摘	O' CALLAGHAN D J O'DONNELL C P PAYNE F A	1999	Journal of Food Engineering1999，41，1：	1

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