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您的检索式：作者名="Calixte Bengone"
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| 1 | Comparison of electrochemiluminescence and ELISA methods in the detection of blood borne pathogens in Gabon显示文摘Objective: To assess the performances of Cobas 6000 e601 and EVOLIS Bio Rad in the detection of HIV, HBV and HCV in blood donors in Libreville(Gabon).Methods: A cross-sectional investigation was conducted in July 2017 in a total of 2 000 blood donors recruited at the National Blood transfusion Center, Libreville Gabon.Among them, 363 donors were selected to compare the performances of COBAS 6000 e601(electro-chemiluminescence) and EVOLIS Bio Rad in detecting HIV, HBV and HCV using Cohen's kappa coefficient.Results: Both methods yielded similar results for the detection of HIV and HBs Ag. A very good agreement of 93.39% and an excellent agreement of 98.90% were obtained for the detection of HIV and Hbs Ag, with kappa values of 0.80 and 0.98, respectively. The observed agreement of 91.86% was found for the detection of HCV, which gave a fair agreement between the two methods with kappa = 0.33.Conclusions: The two evaluation methods showed a similar performance in the detection of HIV, HBV. However, given the high rate of intra and inter-genotypes recombination known for HIV and HBV, more robust techniques of detection such as polymerase chain reaction should be used to prevent post-transfusion contaminations. | Cyrille Bisseye Jophrette Mireille Ntsame Ndong Anicet Mouity Matoumba Calixte Bengone Guy Mouelet Migolet Bolni Marius Nagalo | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，9： | 0 |
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