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| 1 | Anti-rods/rings autoantibody generation in hepatitis Cpatients during interferon-α/ribavirin therapy显示文摘Chronic inflammation associated with hepatitis C virus(HCV) infection can lead to disabling liver diseases with progression to liver cirrhosis and hepatocellular carcinoma. Despite the recent availability of more effective and less toxic therapeutic options, in most parts of the world the standard treatment consists of a weekly injection of pegylated interferon α(IFN-α) together with a daily dose of ribavirin. HCV patients frequently present circulating non-organ-specific autoantibodies demonstrating a variety of staining patterns in the indirect immunofluorescence assay for antinuclear antibodies(ANA). Between 20% to 40% of HCV patients treated with IFN-α and ribavirin develop autoantibodies showing a peculiar ANA pattern characterized as rods and rings(RR) structures. The aim of this article is to review the recent reports regarding RR structures and anti-rods/rings(antiRR) autoantibody production by HCV patients after IFN-α/ribavirin treatment. Anti-RR autoantibodies first appear around the sixth month of treatment and reach a plateau around the twelfth month. After treatment completion, anti-RR titers decrease/disappear in half the patients and remain steady in the other half. Some studies have observed a higher frequency of anti-RR antibodies in relapsers, i.e., patients in which circulating virus reappears after initially successful therapy. The main target of anti-RR autoantibodies in HCV patients is inosine-5'-monophosphate dehydrogenase 2(IMPDH2), the rate-limiting enzyme involved in the guanosine triphosphate biosynthesis pathway. Ribavirin is a direct IMPDH2 inhibitor and is able to induce the formation of RR structures in vitro and in vivo. In conclusion, these observations led to the hypothesis that anti-RR autoantibody production is a human model of immunologic tolerance breakdown that allows us to explore the humoral autoimmune response from the beginning of the putative triggering event: exposure to ribavirin and interferon. | Gerson Dierley Keppeke S John Calise Edward KL Chan Luis Eduardo C Andrade | 2016 | World Journal of Gastroenterology2016，22，6： | 4 |
| 2 | Nonlinear adaptive flight control using neural networks显示文摘 | Calise A Rysdyk R | 1998 | IEEE Control Systems Magazine1998，18，6： | 2 |
| 3 | Assembly of IMPDH2-Based,CTPS-Based,and Mixed Rod/Ring Structures Is Dependent on Cell Type and Conditions of Induction显示文摘Inhibition of guanosine triphosphate(GTP)and cytidine triphosphate(CTP)biosynthetic pathways induces cells to assemble rod/ring(RR)structures,also named cytoophidia,which consist of the enzymes cytidine triphosphate synthase(CTPS)and inosine-50-monophosphate dehydrogenase 2(IMPDH2).We aim to explore the interaction of CTPS and IMPDH2 in the generation of RR structures.He La and COS-7 cells were cultured in normal conditions or in the presence of 6-diazo-5-oxo-L-norleucine(DON),ribavirin,or mycophenolic acid(MPA).Over 90%of DON-treated cells presented RR structures.In He La cells,35%of the RR structures were positive for IMPDH2alone,26%were CTPS alone,and 31%were IMPDH2/CTPS mixed,while in COS-7 cells,42%of RR were IMPDH2 alone,41%were CTPS alone,and 10%were IMPDH2/CTPS mixed.Ribavirin and MPA treatments induced only IMPDH2-based RR.Cells were also transfected with an N-terminal hemagglutinin(NHA)-tagged CTPS1 construct.Over 95%of NHA-CTPS1 transfected cells with DON treatment presented IMPDH2-based RR and almost 100%presented CTPS1-based RR;when treated with ribavirin,over 94%of transfected cells presented IMPDH2-based RR and 37%presented CTPS1-based RR,whereas 2%of untreated transfected cells presented IMPDH2-based RR and 28%presented CTPS1-based RR.These results may help in understanding the relationship between CTP and GTP biosynthetic pathways,especially concerning the formation of filamentous RR structures. | Gerson Dierley Keppeke S.John Calise Edward K.L.Chan Luis Eduardo C.Andrade | 2015 | Journal of Genetics and Genomics2015，42，6： | 2 |
| 4 | Nonlinear flight control using neural networks显示文摘 | Kim B S Calise A J | 1997 | Joumal of Guidance Control and Dynamics1997，20，1： | 1 |
| 5 | Hydrodynamic coefficients for vertical cir cular cylinders at finite depth 显示文摘 | Sabuncu T Calisal S | 1981 | Ocean Engineering1981，，8： | 1 |
| 6 | Output feedback two-time scale control of multilink flexible arms显示文摘 | Siciliano B Prasad J V R Calise A J | 1992 | Transaction of the ASME Journal of Dynamic Systems Measurement and Control1992，114，1： | 1 |
| 7 | Muhilayer Neural Network and Adaptive Nonlinear Control of Agile Antiair Missiles 显示文摘 | Mc Farland M B Calise A J | 2000 | Journal of Guidance Control and Dynamics2000，23，3： | 1 |
| 8 | Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes显示文摘 | Joffre O Santolaria T Calise D | 2008 | Nat Med2008，14，1： | 1 |
| 9 | Nonlinear flight control using neural networks 显示文摘 | Byoung S Kim Athony J Calise | 1997 | Journal of Guidance Control and Dynamics1997，20，1： | 1 |
| 10 | Activation of catalase by apelin prevents oxidative stress linked cardiac hyper- trophy显示文摘 | Foussal C Lairez O Calise D | 2010 | FEBS Lett2010，584，11： | 1 |
| 11 | Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status显示文摘 | Irem Durmaz Ebru Bilget Guven Tulin Ersahin Mehmet Ozturk Ihsan Calis Rengul Cetin-Atalay | 2015 | Phytomedicine2015，，： | 1 |
| 12 | Three-dimensional effects and arm effects on modeling a vertical axis tidal current turbine显示文摘 | LI Y CALISAL S | 2010 | Renewable Energy2010，35，10： | 1 |
| 13 | Nonlinear flight control using neural networks显示文摘 | Calise A J | 1997 | Journal of Guidance Control and Dynamics1997，20，1： | 1 |
| 14 | Nonlinear flight control using neural networks 显示文摘 | Kim B Calise A J | 1997 | Journal of Guidance Control and Dynamics1997，20，1： | 1 |
| 15 | Sensitivity investigation of theSDWBA Antarctic krill target strength model to fatness,material contrasts and orientation 显示文摘 | Calise L Skaret G | 2011 | CCAMLRScience2011，18，： | 1 |
| 16 | Nonlinear adaptive flight control using neural networks 显示文摘 | Calise A J Rysdyk R | 1998 | IEEE Control System Magazine1998，18，6： | 1 |
| 17 | Nonlinear Flight Control Using Neural Networks显示文摘 | Kim B S Calise A J | 1997 | AIAA J of Guidance Control and Dynamics1997，20，1： | 1 |
| 18 | Adaptive control of a class ofnonattlne systems using neural networks 显示文摘 | YANG B J CALISE A J | 2007 | IEEE Trans- actions on Neural Networks2007，18，4： | 1 |
| 19 | Prognosis of patients with spontaneous rupture of hepatocellular carcinoma in cirrhosis显示文摘 | Tarantino L Sordelli 1 Calise F | 2011 | Updates Surg2011，63，1： | 1 |
| 20 | Simulation and exergy analysis of a hybrid Solid Oxide Fuel Cell (SOFC) - Gas Turbine System 显示文摘 | F Calise | 2006 | Energy2006，31，15： | 1 |
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