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| 1 | 华北燕山带:构造、埃达克质岩浆活动与地壳演化(英文)显示文摘埃达克质火成岩在中国东部,包括燕山带是很常见的,一般认为它们是下地壳不均匀的镁铁质岩石及/或富集的上地幔岩石在高压(≥1.5 GPa)下部分熔融的结果。在燕山带内埃达克岩浆的形成有一个很长的时间(约190~80 Ma),然而岩浆活动的峰期却与约170~130 Ma间有基底岩石卷入的陆壳收缩期相一致。尽管埃达克质岩浆活动的历史很长,但那种把岩浆活动与岩石圈的拆沉效应相联系的模式似乎是不适当的。在该带内,埃达克质与非埃达克质岩浆活动有一部分是同时的,而且在地理分布上也是相间的,这说明了在下地壳和上地幔岩石的部分熔融中成分是相当不均匀的。侏罗纪及白垩纪熔融作用的热源应当是与古太平洋板块俯冲相关的中生代板底垫托的玄武岩浆。除了局部例外,在燕山带,埃达克质岩浆活动的终结和碱性岩浆活动的开始约在130~120 Ma,在此时期收缩作用使东亚大达200万km^2以上的地区发生了NW—SE向的区域性伸展作用。强烈的地壳伸展仅局限于华北克拉通北缘分布的少数几个变质核杂岩中。陆壳的伸展减薄合理地解释了130~120 Ma间发生高压埃达克质熔融条件的终结,尽管还有局部年轻的埃达克火山活动(约120~80Ma)可以在伸展规模有限而厚的地壳依然存在的地区继续出现。燕山区早白垩世的碱性侵入体中的锆石不存在前寒武纪? | Gregory A. DAVIS Department of Earth Sciences, University6 of Southern California, Los Angeles,California 90089-0740 USA Department of Geology , China University of Geosciences , Beijing 100083, China | 2003 | 地学前缘2003，10，4： | 46 |
| 2 | Early J_2 basalts in SE China:Incipience of large-scale late Mesozoic magmatism显示文摘Magmatism in SE China was dormant during 204―180 Ma, but was reactivated in 180― 170 Ma (early J2), and then became more and more intensive towards the end of early Cretaceous. The small-scale early J2 magmatism is the incipience to long-term and large-scale magmatism in this region. A near east-west (EW) trend volcanic belt was distributed across south Hunan, south Jiangxi and southwest Fujian was formed during early J2 time. Along this belt from the inland toward the coast, the lithology of basalts changes from alkali into tholeiite, and the amount of erupted volcanic rocks and the proportions of rhyolites coexisting with the basalts increase. On the basis of geochemical char- acteristics of these basalts, we infer that the melting degree of source rocks and the extent of frac- tional crystallization and crustal contamination all increased whereas the depth of mantle source de- creased from the inland to the coast, which led to the variations of geological characteristics of the volcanic belt. In early J2, the western spreading Pacific plate began to subduct underneath SE China continental block, reactivating near EW trend deep fault that was originally formed during the Indos- inian event. The stress of the western spreading Pacific plate and the extent of asthenosphere up- welling increased from the inland to the coast, which is consistent with the generation and evolution of early J2 basalts. | XIE Xin1, XU Xisheng1, ZOU Haibo2, JIANG Shaoyong1, ZHANG Ming3 & QIU Jiansheng1 1. State Key Laboratory of Mineral Deposit Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Department of Earth and Space Sciences, University of California at Los Angeles, Los Angeles, CA90095-1567, USA. 3. GEMOC ARC National Key Centre, Department of Earth and Planetary Sciences, Macquarie University, Sydney, N.S.W. 2109, Australia | 2006 | Science China Earth Sciences2006，49，8： | 30 |
| 3 | Cytochrome P450 2E1 genetic polymorphism and gastric cancer in Changle,Fujian Province显示文摘AIM: Genetic polymorphism in enzymes of carcinogen metabolism has been found to have the influence on the susceptibility to cancer. Cytochrome P450 2E1 ( CYP2 E1) is considered to play an important role in the metabolic activation of procarcinogens such as N-nitroscoamines and Iow molecular weight organic compounds. The purpose of this study is to determine whether CYP450 2Elpolymorphisms are associated with risk s of gastric cancer.METHODS: We conducted a population based case-control study in Changle county, Fujian Province, a high-risk region of gastric cancer in China. Ninety-one incident gastric cancer patients and ninety-four healthy controls were included in our study. Datas including dsmographic characteristcs, diet intake, and alcohol and tobacco consumption of indivduals in our study were completed by a standardized questionnaire. PCR-RFLP revealed three genotypes: heterozygote (C1/C2) and two homozygotes (C1/C1 and C2/C2) in CYP2E1.RESULTS: The frequency of variant genotypes (C1/C2 and C2/C2) in gastric cancer cases and controls was 36.3% and 24.5%, respectively. The rare homozygous C2/C2 genotype was found in 6 indivduals in gastric cancer group(6.6%),whereas there was only one in the control group (1.1%).However, there was no statistically significan difference between the two groups (two-tailed Fisher′s exact test, P =0.066). Indivduals in gastric cancer group were more likely to carry genotype C1/C2 (odds ratio, OR = 1.50) and C2/C2(OR = 7.34) than indivduals in control group (X2 = 4.597, for trend P=0.032). The frequencies of genofypes with the C2allele ( C1/C2 and C2/C2 genotypes) were compared with those of genotypes without C2 allele ( C1/C1 genotype )among indivduals in gastric cancer group and control group according to the pattern of gastric cancer risk factors. The results show that indivduals who exposed to these gastric cancer risk factors and carry the C2 allele seemed to have a higher risk of developing gastric cancer.CONCLUSION: Polymorphism of CYP2E1 gene may have some effct in the development of gastric cancer in Changle county, Fujian Province. | Lin Cai~1 Shun-Zhang Yu~2 Zuo-Feng Zhang~3 1 Department of Epidemiology,Fujian Medical University,Fuzhou 350004,Fujian Province,China2 Department of Epidemiology,Shanghai Medical University,Shanghai 200032,China3 Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 25 |
| 4 | Glutathione S-transferases M1,T1 genotypes and the risk of gastric cancer:A case-control study显示文摘AIM Glutathione S-transferases (GSTs are involved in the detoxification of many potential carcinogens and appear to play a critical role in the protection from the effects of carcinogens. The contribution of glutathione Stransferases M1 and T1 genotypes to susceptibility to the risk of gastric cancer and their interaction with cigarette smoking are still unclear. The aim of this study was to determine whether there was any relationship between genetic polymorphisms of GSTM1 and GSTT1 and gastric cancer.METHODS A population based case - control study was carried out in a high-risk area, Changle County, Fujian Province, China. The epidemiological data were collected by a standard questionnaire and blood samples were obtained from 95 incidence gastric cancer cases and 94 healthy controls. A polymerase chain reaction method was used to detect the presence or absence of the GSTM1 and GSTT1 genes in genomic DNA. Logistic regression model was employed in the data analysis.RESULTS An increase in risk for gastric cancer was found among carriers of GSTM1 null genotype. The adjusted odds ratio (OR) was 2.63 [95% Confidence Interval (95% CI) 1.17-5.88], after controlling for age,gender, cigarette smoking, alcohol drinking, and fish sauce intake. The frequency of GSTT1 null genotype in cancer cases (43.16%) was not significantly different from that in controls (50.00%). However, the risk for gastric cancer in those with GSTM1 null and GSTT1 nonnull genotype was significantly higher than in those with both GSTM1 and GSTT1 non-null genotype (OR = 2.77,95% Cl 1.15- 6.77). Compared with those subjects who never smoked and had normal GSTM1 genotype, Ors were 1.60 (95% CI: 0.62- 4.19) for never smokers with GSTM1 null type, 2.33 (95% CI 0.88- 6.28) for smokers with normal GSTM1, and 8.06 (95% CI 2.83- 23.67) for smokers with GSTM1 null type.CONCLUSIONS GSTM1 gene polymorphisms may be associated with genetic susceptibility of stomach cancer and may modulate tobacco-related carcinogenesis of gastric cancer. | Lin Cai Shun-Zhang Yu Zuo-Feng Zhang Department of Epidemiology.Fujian Medical University,Fuzhou 350004,Fujian Province,ChinaDepartment of Epidemiology,Shanghai Medical University,Shanghai 200032,China Department of Epidemiology,UCLA School of Public Health,Los Angeles California,USA | 2001 | World Journal of Gastroenterology2001，7，4： | 22 |
| 5 | Change of surface cover greenness in China between 2000 and 2010显示文摘Surface greenness reflects the situation of vegetation cover.Vegetation index calculated from the Red and Near Infrared bands of remote sensing images,whose values indicate the level of photosynthetic activity,is monotonically related to surface greenness when vegetation canopy does not fully cover the background soil.Especially for desert regions,vegetation index is positively correlated with vegetation coverage.Therefore,vegetation index can be used to study the change in greenness of desert areas.This study collected MODIS Normalized Difference Vegetation Index (NDVI) data from 2000 to 2010 and analyzed their change over China in this period.The results showed that an increasing trend of NDVI occurred over 66.84% (OLS fitting) or 64.27% (LAD fitting) of China,indicating that China's greenness is increasing overall.Meanwhile,desertification of China decreased.Areas showing large increase in greenness are found in Shaanxi,Shanxi,Ningxia,Henan,Shandong,Qinghai,and Gansu while regions with large decrease in greenness are found in Northeast Inner Mongolia,South Tibet,Jiangsu,and Shanghai.Changes of Qinghai,Gansu,Xinjiang and South Tibet could probably be driven by climate factors.Decrease of greenness in Northeast Inner Mongolia was related to agricultural reclamation.Decrease of greenness in Jiangsu and Shanghai was related to rapid urbanization.Climate factors did not exhibit obvious correspondence to the large increase in greenness in Shaanxi,Shanxi,Ningxia and Gansu,indicating that the changes might have been caused by human factors.The reduction of desert areas in China could probably have been caused by human management and protection at the national scale. | LIU Shuang1,4& GONG Peng1,2,31State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing Applications of Chinese Academy of Sciences,and Beijing Normal University, Beijing 100101, China 2Institute for Global Change Studies & Center for Earth System Science, Tsinghua University, Beijing 100084, China 3Department of Environmental Science, Policy and Management, University of California, Berkeley, CA94720, USA 4Graduate University of Chinese Academy of Sciences, Beijing 100049, China | 2012 | Chinese Science Bulletin2012，57，22： | 23 |
| 6 | A Genome-wide Functional Characterization of Arabidopsis Regulatory Calcium Sensors in Pollen Tubes显示文摘Calcium, an ubiquitous second messenger, plays an essential and versatile role in cellular signaling. The diverse function of calcium signals is achieved by an excess of calcium sensors. Plants possess large numbers of calcium sensors, most of which have not been functionally characterized. To identify physiologically relevant calcium sensors in a specific cell type, we conducted a genome-wide functional survey in pollen tubes, for which spatiotemporal calcium signals are well-characterized and required for polarized tip growth. Pollen-specific members of calmodulin (CaM), CaM-like (CML), calcium-dependent protein kinase (CDPK) and calcineurin B-like protein (CBL) families were tagged with green fluorescence protein (GFP) and their localization patterns and overexpression phenotypes were characterized in tobacco pollen tubes. We found that several fusion proteins showed distinct overexpression phenotypes and subcellular localization patterns. CDPK24-GFP was localized to the vegetative nucleus and the generative cell/sperms. CDPK32-GFP caused severe growth depolarization. CBL2-GFP and CBL3-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane (PM), and cytoskeleton-like structures in pollen tubes. Their overexpression also inhibited pollen tube elongation and induced growth depolarization. These putative calcium sensors are excellent candidates for the calcium sensors responsible for the regulation of calcium homeostasis and calciumdependent tip growth and growth oscillation in pollen tubes. | Liming Zhou1,2, Ying Fu1,2 and Zhenbiao Yang2,3 (1State Key Laboratory of Plant Physiology and Biochemistry, Department of Plant Sciences, College of Biological Sciences, China Agricultural University, Beijing 100193, China 2China Agricultural University (CAU)-University of California, Riverside (UCR) Joint Center for Biological Sciences and Biotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China 3Center for Plant Cell Biology and Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA) | 2009 | Journal of Integrative Plant Biology2009，51，8： | 21 |
| 7 | TRAF-mediated regulation of immune and inflammatory responses显示文摘The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family consists of six mammalian members,and is shown to participate in signal transduction of a large number of receptor families including TNF receptor family (TNFR) and Toll-like receptors-interleukin-1 receptors (TLR-IL-1R) family.Upon receptor activation,TRAFs are directly or indirectly recruited to the intracellular domains of these receptors.They subsequently engage other signaling proteins to activate inhibitor of κB kinase (IKK) complex,TRAF family member-associated NF-κB activator (TANK)-binding kinase 1 (TBK1) and inducible I κB kinase (IKK-i) (also known as IKKε),ultimately leading to activation of transcription factors such as NF-κB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses. | WANG YaYa1,ZHANG Peng2,LIU YingFang2 & CHENG GenHong1 1 Department of Microbiology,Immunology & Molecular Genetics,University of California Los Angeles,609 Charles E.Young Drive East,Los Angeles,California 90095,USA 2 National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing 100101,China | 2010 | Science China(Life Sciences)2010，53，2： | 19 |
| 8 | On linking climate to Chinese dynastic change: Spatial and temporal variations of monsoonal rain显示文摘The causal correlation or linkage between the East Asian Monsoon (EAM) intensity and rise/fall of Chinese dynasties recently proposed by high-resolution paleoclimate reconstructions is examined in detail. Aside from many exceptions to the correlation, both instrumental and historical climate records show strong spatial variations of rainfall on annual-to-decadal scales over eastern China. The relationship between rainfall and EAM intensity also exhibits regional disparity. These observations suggest: (1) Tak-ing paleo-proxy records from a single locality in eastern China to imply changes in drought/wetness as to affect the cultural and political history of China is fraught with uncertainty. (2) On annual-to-decadal scales, the thesis that δ18O in speleothems can be used as a proxy for the EAM strength lacks empirical underpinnings. | ZHANG DeEr1, LI Hong-Chun2,3, KU Teh-Lung2,4 & LU LongHua5 1 National Climate Center, Beijing 100081, China 2 Department of Earth Sciences & Research Center of Ocean Environment and Technology, Cheng-Kung University, Tainan 70101, Taiwan, China 3 School of Geographical Sciences, Southwest University of China, Chongqing 400715, China 4 Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089, USA 5 Chinese Academy of Meteorological Sciences, Beijing 100081, China | 2010 | Chinese Science Bulletin2010，55，1： | 19 |
| 9 | Caveolin-1 gene silencing promotes the activation of PI3K/AKT dependent on Erα36 and the transformation of MCF10A^(CE)显示文摘ERα36,a variant of estrogen receptor-α,acts as a dominant-negative factor in both estrogen-dependent and estrogen-independent transactivation signaling pathways,and is a key factor in the promotion,progression and prognosis of breast cancers.Caveolin-1,a 22-to 24-kD integral membrane protein,may function as a tumor suppressor in inhibiting of many growth-promoting signaling pathways.It was shown that downregulation of Caveolin-1 strengthens the interaction of ERα and Caveolin-1.In conclusion,Caveolin-1 gene silencing activated the PI3K/AKT signaling pathway in an ERα36-dependent way.Our finding may provide a promising therapeutic target of breast cancer. | FENG Shuang1,WANG Yang1,WANG Xi1,WANG ZhaoYi3,CUI YuYing1,LIU Jing4,ZHAO ChunHui1,JIN Mei1,2 & ZOU Wei1,2 1 College of Life Science,Liaoning Normal University,Dalian 116029,China 2 Liaoning Key Laboratory of Biotechnology and Molecular Drug R&D,Dalian 116029,China 3 Cancer Center,Creighton University,2500 California Plaza,Omaha,NE 68178,USA 4 First Clinical Hospital of Dalian Medical University,Dalian 116011,China | 2010 | Science China(Life Sciences)2010，53，5： | 16 |
| 10 | Endoscopic ultrasonography guided biliary drainage: Summary of consortium meeting, May 7^(th) , 2011, Chicago显示文摘Endoscopic retrograde cholangiopancreatography (ERCP) has become the preferred procedure for biliary or pancreatic drainage in various pancreatico-biliary disorders. With a success rate of more than 90%, ERCP may not achieve biliary or pancreatic drainage in cases with altered anatomy or with tumors obstructing access to the duodenum. In the past those failures were typically managed exclusively by percutaneous approaches by interventional radiologists or surgical intervention. The morbidity associated was significant especially in those patients with advanced malignancy, seeking minimally invasive interventions and improved quality of life. With the advent of biliary drainage via endoscopic ultrasound (EUS) guidance, EUS guided biliary drainage has been used more frequently within the last decade in different countries. As with any novel advanced endoscopic procedure that encompasses various approaches, advanced endoscopists all over the world have innovated and adopted diverse EUS guided biliary and pancreatic drainage techniques. This diversity has resulted in variations and improvements in EUS Guided biliary and pancreatic drainage; and over the years has led to an extensive nomenclature. The diversity of techniques, nomenclature and recent progress in our intrumentation has led to a dedicated meeting on May 7 th , 2011 during Digestive Disease Week 2011. More than 40 advanced endoscopists from United States, Brazil, Mexico, Venezuela, Colombia, Italy, France, Austria, Germany, Spain, Japan, China, South Korea and India attended this pivotal meeting. The meeting covered improved EUS guided biliary access and drainage procedures, terminology, nomenclature, training and credentialing; as well as emerging devices for EUS guided biliary drainage. This paper summarizes the meeting's agenda and the conclusions generated by the creation of this consortium group. | Michel Kahaleh Everson LA Artifon Manuel Perez-Miranda Kapil Gupta Takao Itoi Kenneth F Binmoeller California Pacific Medical Center San Francisco CA 94115 United States Marc Giovannini | 2013 | World Journal of Gastroenterology2013，19，9： | 15 |
| 11 | Some Suggested Future Directions ofQuantitative Resource Assessments显示文摘Future quantitative assessments will be expected to estimate quantities, values, and locations of undiscovered mineral resources in a form that conveys both economic viability and uncertainty associated with the resources. Historically, declining metal prices point to the need for larger deposits over time. Sensitivity analysis demonstrates that the greatest opportunity for reducing uncertainty in assessments lies in lowering uncertainty associated with tonnage estimates. Of all errors possible in assessments, these affecting tonnage estimates are by far the most important. Selecting the correct deposit model is the most important way of controlling errors because of the dominance of tonnage-deposit models are the best known predictors of tonnage. Much of the surface is covered with apparently barren rocks and sediments in many large regions. Because many exposed mineral deposits are believed to have been found, a prime concern is the presence of possible mineralized rock under cover. Assessments of areas with resources under cover must rely on extrapolation from surrounding areas, new geologic maps of rocks under cover, or analogy with other well-explored areas that can be considered training tracts. Cover has a profound effect on uncertainty and on methods and procedures of assessments because geology is seldom known and geophysical methods typically have attenuated responses. Many earlier assessment methods were based on relationships of geochemical and geophysical variables to deposits learned from deposits exposed on the surface-these will need to be relearned based on covered deposits. Mineral-deposit models are important in quantitative resource assessments for two reasons: (1) grades and tonnages of most deposit types are significantly different, and (2) deposit types are present in different geologic settings that can be identified from geologic maps. Mineral-deposit models are the keystone in combining the diverse geoscience information on geology, mineral occurrences, geophysics, and geochemistry used in resource assessments and mineral exploration. Grade and tonnage models and development of quantitative descriptive, economic, and deposit density models will help reduce the uncertainty of these new assessments. | Singer Donald A U. S. Geological Survey, 345 Middlefield Road, Menlo Park, California 94025, USA | 2001 | Journal of China University of Geosciences2001，12，1： | 15 |
| 12 | 盆地演化认识中的几个问题显示文摘本文论述了盆地演化认识中的几个主要问题。一是陆缘裂解过程,华南边缘传统上认为是被动裂谷边缘的一个例子,其东部沉积物记录了压实的历史,它明显不同于被动裂谷作用模式,而是显示早第三纪大规模上隆和侵蚀的特征;而且,该地区覆盖在下地壳楔形体上面,具有比周围地壳明显要高的地震速度和密度,指示岩浆底侵作用。这些证据说明,与被动裂谷作用模式相比,华南边缘与主动裂谷作用模式较为一致,它是由早第三纪华南边缘东部底下地幔柱形成的主动裂谷。另一个问题是关于页岩的浅部破裂作用机理。大多数研究者认为,微裂隙的形成需要高孔隙压力,它限于深埋、低渗透率的岩石。然而,最近从北海观察表明,在第三纪页岩中,整个盆地范围内的破裂型式从未达到大于几百米的埋藏深度。这说明泥质源岩经历了水压破裂和浅部脱水,在破裂前可能达到深埋后生作用所需要的深度,实质上渗透率的改变是由于源岩的浅部破裂作用可能根本上改变了烃类的初次运移时间和效率。 | Wang Chiyuen(Department of Geology and Geophysics University of California,Berkeley,CA 94720)Yang Jiaming Zhu Weilin(Exploration and Development Research Center,China National Offshore Oil Corporation,Xincheng,074010)Zheng Mingling(Scientific Research Ce | 1995 | 地学前缘1995，2，3： | 14 |
| 13 | A novel mutation at the JK locus causing Jknull phenotype in a Chinese family显示文摘Urea transporters are a group of proteins that facilitate urea movement across biological membranes. Kidd blood group (JK antigen) and urea transporter of human erythrocytes are carried by the same protein UT-B. To investigate the molecular basis of the Jknull phenotype in the Chinese population, blood samples from Chinese individuals were screened using the 2 mol/L urea solution hemolysis test. Urea and water permeability of erythrocytes membrane was measured by stopped-flow light scattering. Genomic DNA was extracted from lymphocytes. UT-B gene of Jknull's family was analyzed using genomic PCR by primers designed to cover sequences of all exons and exon-intron boundaries in human UT-B gene. One Jknull subject was found from twenty thousand screened Chinese individuals, and it was confirmed that this individual did not express the erythrocyte urea transporter. Genomic sequence analysis of the Jknull individual showed that there were two point mutations, G→C, which is novel, and G→A, at the 3(-acceptor splice site (AG) of intron 5 of UT-B gene. Exon 6 is spliced out in the UT-B transcript due to either of these mutations. Water permeability in Jknull erythrocytes (Pf, ~0.00037 cm/s) was significantly lower than that in normal erythrocytes (Pf, ~0.00062 cm/s) after HgCl2 incubation, providing evidence for UT-B facilitated water transport in human erythrocytes. | MENG Yan1, ZHOU Xueyan2, LI Yang1, ZHAO Dan1, LIANG Shuyuan2, ZHAO Xuejian1, YANG Baoxue1,3 1. Department of Pathophysiology, School of Medical Science, Jilin University, Changchun 130021, China 2. The Third Hospital of Jilin University, Changchun 130031, China 3. Departments of Medicine, University of California, San Francisco, CA, 94143-0521, USA | 2005 | Science China(Life Sciences)2005，48，6： | 13 |
| 14 | Moving toward an understanding of the metastatic process in hepatocellular carcinoma显示文摘INTRODUCTIONClinical factors contributing to the therapeutic challenge of hepatocellular carcinoma (HCC) are manifold :tumors arise often in patients with compromised liver function ,therefore limiting therapeutic options ;symptoms develop only at later stages of tumor progression ,and tumors tend to invade normal stuctures or occur in multiple locations simultaneously. | W.Michael Korn Division of Gastroenterology and Comprehensive Cancer Canter,University of California San Francisco,San Francisco,CA 94143-0128,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 13 |
| 15 | No apparent lock-in depth of the Laschamp geomagnetic excursion: Evidence from the Malan loess显示文摘The first-order chronological framework of the long-term Chinese loess/paleosol sequences was based mainly on magnetostratigraphy. However, there remain arguments on the lock-in ages of the major geomagnetic reversals. This study systematically compared the stratigraphic locations of the Laschamp excursion and Henrich events (H4 at~39 ka and H5 at~48 ka) recorded by the Luochuan loess profile in the central Chinese Loess Plateau. Results show that the Lascchamp excursion is bracketed well by these two cold events, and the corresponding estimated age is between about 41.7-43.7 ka, which is close to the widely accepted age of ~40-41 ka for the excursion.Therefore, our new results do not suggest apparent lock-in effects in the last glacial Malan loess. | ZHU Rixiang1, LIU Qingsong1,2, PAN Yongxin1, DENG Chenglong1, ZHANG Rui1 & WANG Xianfeng3 1. Paleomagnetism and Geochronology Laboratory (SKL of Lithosphere Evolution), Institute of Geology and Geophysics, Chi- nese Academy of Sciences, Beijing 100029, China 2. Institute of Geophysics and Planetary Geophysics, University of California, Santa Cruz, CA 95064, USA 3. Department of Geology and Geophysics, University of Minnesota, Minneapolis, MN 55455, USA | 2006 | Science China Earth Sciences2006，49，9： | 12 |
| 16 | 骨岛(内生骨疣)的影像学和病理学特征回顾显示文摘骨岛(内生骨疣)的影像学和病理学特征回顾AdamGreenspan,M.D.BoneIsland(Enostosis):AReviewofImagingandPathologicCharacteristics￥AdamGreenspan,M.D.De... | Adam Greenspan,M.D.Department of Diagnostic Radiology,(University of California,Davis Medical Center 2516 Stockton Blvd.,Ticon Ⅱ Sacramento,CA 95817,U.S.A.) | 1996 | 临床放射学杂志1996，15，2： | 10 |
| 17 | Discovery and analysis of ultra-micro grinding grain texture in slipping lamellae of ductile-brittle zone显示文摘Based on the observation of the deep bore cores sampled from the State of Cali-fornia, USA, preferred arranged particulate concentration belts were found in the ultra-slipping lamellae. And the same phenomenon was found again later in the bore cores from the petroleum basin in the Northern Shaanxi Province. It may be the product of the dynamic processes involv-ing tumbling, grinding and compresso-shearing functions, so the spherical particulates with ul-tra-size of nm and mm are called grinding grain. The formation of the grinding grains is related with the ductile-brittle deformation, the lateral pressure of the slipping, and the very low grade of dynamic metamorphism of the rocks. Based on the systematic analysis, it is indicated that some elements like Nb and Ta are enriched in the grinding grains in the granitic rocks because of the chemical differentiation, and that the slipping lamellae bearing grinding grains in mudstone with smear efficiency prove a perfect seal for oil and gas reservoirs. Meanwhile, the paper provides bases for the studies on the fast stick-slip movement and shear paradigm. | GE Heping1, SUN Yan1, LU Xiancai1, ZHU Wenbin1, GUO Jichun1, LIU Deliang2 & Chi-yuen Wang3 1. Department of Earth Sciences, Nanjing University, State Key Laboratory of Mineral Deposit, Nanjing 210093, China 2. Department of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, China 3. Department of Geology and Geophysics, University of California, Berkeley, CA 94720, USA | 2004 | Science China Earth Sciences2004，47，3： | 9 |
| 18 | Successful outpatient management of acute upper gastrointestinal hemorrhage:use of practice guidelines in a large patient series显示文摘Successfuloutpatientmanagementofacuteuppergastrointestinalhemorhage:useofpracticeguidelinesinalargepatientseriesGeorgeF.Longs... | George F. Longstreth, MD, Steven P. Feitelberg, MD Department of Medicine Kaiser Permanente Health care Pragram, San Diego, California | 1998 | World Journal of Gastroenterology1998，4，3： | 8 |
| 19 | Paleotemperature changes over the past 3000 years in eastern Beijing, China: A reconstraction based on Mg/Sr records in a stalagmite显示文摘The Mg/Sr ratio in a stalagmite, which is di-rectly proportional to DMg/Ca, the solid-liquid distribution coefficient of Mg, is proposed as a geochemical thermometer to estimate paleotemperature changes. The paleotempera-ture change in eastern Beijing over the past 3000 years has been reconstructed by using this thermometer in the stalag-mite ZFFS-1 from Jingdong Cave. The records can be di-vided into two periods: 3000—2000 aBP, cool and wet, the air temperature averaging 9.8℃; and 2000 aBP—present, hot and dry, the air temperature being 1℃ higher than the mean value (11.7℃) of the past 3000 years. During 500—200 aBP, the air temperature was about 1.2℃ lower than that of the present, corresponding to the Little Ice Age in Europe. Like d 18O and d 13C, Mg/Sr (or DMg/Ca) reflects an obviously warming trend of the past 200 years. These results are sup-ported by historic records. | MA Zhibang1, LI Hongchun2, XIA Ming1, KU Tehlung2, PENG Zicheng3, CHEN Yushu4 & ZHANG Zhaofeng3 1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Earth Sciences, University of Southern California, Los Angeles, CA90089-0740, USA 3. Department of Earth and Space Science, University of Science and Technology of China, Hefei 230026, China 4. Beijing Foshan Tourist Service Centre, Beijing 101201, China | 2003 | Chinese Science Bulletin2003，48，4： | 8 |
| 20 | Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells显示文摘Breast cancer-specific gene 1 (BCSG1), also referred as synuclein γ, was originally iso-lated from a human breast cancer cDNA library and the protein is mainly localized to presynaptic terminals in the nervous system. BCSG1 is not expressed in normal or benign breast lesions, but expressed at an extremely high level in the vast majority of the advanced staged breast carcinomas and ovarian carcinomas. Overexpression of BCSG1 in cancer cells led to significant increase in cell proliferation, motility and invasiveness, and metastasis. To elucidate the molecular mechanism and regulation for abnormal transcription of BCSG1, a variety of BCSG1 promoter luciferase reporters were constructed including 3′ end deleted sequences, Sp1 deleted, and activator protein-1 (AP1) domains mutated. Transient transfection assay was used to detect the transcriptional activation of BCSG1 promoters. Results showed that the Sp1 sequence in 5′-flanking region was involved in the basal transcriptional activities of BCSG1 without cell-type specificity. In comparison to pGL3-1249, the reporter activities of pGL3-1553 in BCSG1-negative MCF-7 cells and pGL3-1759 in HepG2 cells were notably decreased. Mutations at AP1 sites in BCSG1 intron 1 significantly reduced the promoter ac-tivity in all cell lines. Transcription factors, c-jun, c-fos and cyclin AMP-responsive element binding (CREB) protein, could markedly enhance the promoter activities. Thus, our results suggest that the abnormal expression of BCSG1 in breast cancer cells is likely regulated by multiple mechanisms. The 5′ flanking region of BCSG1 provides the basal transcriptional activity without cell type specificity. A critical promoter element involved in abnormal expression of BCSG1 presents in the first exon. The cell type specificity of BCSG1 transcription is probably affected through intronic cis-regulatory se-quences. AP1 domains in the first intron play an important role in control of BCSG1 transcription. | LU Aiping1, LI Qing1, LIU Jingwen2 1. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China 2. VA Palo alto Health Care System, Palo Alto, California, CA 94304, USA | 2006 | Science China(Life Sciences)2006，49，4： | 8 |
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