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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Compari-son of drug transporter levels in normal colon,colon cancer,and Caco-2 cells:impact on drug disposition and discovery显示文摘 | CALCAGNO A M LUDWIG J A FOSTEL J M | 2006 | Mol Pharm2006，3，1： | 1 |
| 4 | Effects of aripiprazole,olanzapine,and haloperidol in a model of cognitive deficit of schizophrenia in rats:relationship with glutamate release in the medial prefrontal cortex显示文摘 | Carli M Calcagno E Mainolfi P | | 0，，03： | 1 |
| 5 | Ascitic pseudouridine discriminates between hepatocarcinoma derived ascites and cirrhotic ascites 显示文摘 | Castaldo G Intrieri M Calcagno G | 1996 | Clin Chem1996，42，11： | 1 |
| 6 | Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes显示文摘 | A M Calcagno J M Fostel K K W To | 2008 | British Journal of Cancer2008，98，： | 1 |
| 7 | The effect of or-ganic modifier of the clay on morphology and crystallization proper- ties of PET nanoeomposites显示文摘 | Calcagno C I W Mariani C M Teixeira S R | 2007 | Polymer2007，48，4： | 1 |
| 8 | Vaginal estrogen therapy and overactive bladder symptoms in postmenopausal patients after a tension-free vaginal tape procedure:a randomized clinical trial显示文摘 | Plotti F Calcagno M | 2005 | Menopause2005，12，： | 1 |
| 9 | The effect of organic modifier of the clay on morphology and crystallization properties of PET nanoeomposites 显示文摘 | CALCAGNO C MARIANI C M TEIXEIRA S R | 2007 | Polymer2007，48，4： | 1 |
| 10 | Interaction of Leishma- nia mexicana promastigotes with the plasminogen-plasmin system 显示文摘 | Avilm L Calcagno M Figuera M | 2000 | Mol Bioehem Parasitol2000，110，2： | 1 |
| 11 | The novel hormone INSL3 is expressed in human testicular Leydig cell tumors : a clinicaland immunohistoohemical study显示文摘 | Rossato M Tavolini IM Calcagno A | 2011 | Urol Oncol2011，29，1： | 1 |
| 12 | Interaction of different Leishmania mexicana morphotypes with plasminogen 显示文摘 | Calcagno M AvilOn L Colasante C | 2002 | Parasitol Res2002，88，11： | 1 |
| 13 | Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics显示文摘 | Calcagno A M Salcido C D Gillet J P | 2010 | J Natl Cancer Inst2010，102，21： | 1 |
| 14 | The novel hormone INSL3 is expressed in human testicular Leydig cell tumors: a clinical and immunohistochemical study显示文摘 | Rossato M Tavolini IM Calcagno A | 2011 | Urol Oncol2011，29，1： | 1 |
| 15 | One-year follow-up of tension-free vaginal tape(TVT) and trans-obturator suburethral tape from inside to outside(TVT-O) for surgical treatment of female stress urinary incontinence:a prospective randomised trial显示文摘 | Zullo MA Plotti F Calcagno M | 2007 | Eur Urol2007，51，5： | 1 |
| 16 | The novel hormone INSL3 is expressed in human testicular Leydig cell tumors:a clinical and immunohistochemical study显示文摘 | Rossato M Tavolini IM Calcagno A | 2011 | Urol Oncol2011，29，1： | 1 |
| 17 | Interaction of Leishmania mexicana promastigotes with the plasminogen-plasmin system 显示文摘 | Avilan L Calcagno M Figuera M | 2000 | Mol Biochem Parasitol2000，110，2： | 1 |
| 18 | Interaction of different Leishmania mexicana morphotypes with plasminogen显示文摘 | Calcagno M Avilan L Colasante C | 2002 | Parasitol Res2002，88，11： | 1 |
| 19 | Brcal breast tumours contain distinct CD44+/CD24 and CD133^+ cells with cancer stem cell characteristics显示文摘 | Wright M H Calcagno A M Salcido C D | 2008 | Breast Cancer Res2008，10，： | 1 |
| 20 | Brca1 breast tumors contain distinct CD44+/CD24-and CD133+ cells with cancer stem cell characteristics显示文摘 | Wright M H Calcagno A M Salcido C D | 2008 | Breast Cancer Res2008，10，1： | 1 |
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