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| 1 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 2 | Hermes:An infrastructure for low area overhead packet-switching networks on chip显示文摘 | MORAES F CALAZANS N MELLO A | 2004 | Integration the VLSI Journal2004，38，1： | 1 |
| 3 | Dynamic task mapping for MPSoCs显示文摘 | De Carvalho S E L Calazans N L V Moraes F G | 2010 | IEEE Design & Test of Computers2010，27，5： | 1 |
| 4 | Comparison of network-on chip mapping algorithms targeting low energy consumption 显示文摘 | Mareon C A M Moreno E I Calazans N L V | 2008 | Computers & Digital Techniques2008，2，6： | 1 |
| 5 | Plant Design Project Automation Using an Automatic Pipe Routing Routine 显示文摘 | CALIXTO E E S BORDEIRA P G CALAZANS H T | 2009 | Computer Aided Chemical Engineer- ing2009，，27： | 1 |
| 6 | First-Line Paclitaxel and Carboplatin in Persistent/Recurrent or Advanced Cervical Cancer: A Retrospective Analysis of Patients Treated at Brazilian National Cancer Institute显示文摘 | álvaro Henrique Ingles Garces Paulo Alexandre Ribeiro Mora Flávia Vieira Guerra Alves Claudio Calazan do Carmo Rachele Grazziotin Anna Cristina Ferr?o Mangia Fernandes Angélica Nogueira-Rodrigues Andréia Cristina de Melo | 2013 | International Journal of Gynecological Cancer2013，，4： | 1 |
| 7 | Effect of salinity on survival, growth, food consumption and haemolymph osmolality of the pink shrimp Farfantepenaeus subtilis (Prrez-Farfante, 1967) 显示文摘 | Silva E Calazans N Soares M | 2010 | Aquaculture2010，306，1： | 1 |
| 8 | Dynamic task mapping for MPSoCs显示文摘 | E Carvalho N Calazans F Moraes | 2010 | IEEE Design and Test of Computers2010，27，5： | 1 |
| 9 | A hardware accelerator for particle swarm optimization显示文摘 | CALAZAN R M NEDJAH N MOURELLE L M | 2014 | Applied Soft Computing2014，14，： | 1 |
| 10 | Low accumulation of L90M in protease from subtype F HIV-1 with resistance to PI is caused by the L89M polymorphism显示文摘 | Calazans A Brindeiro R Brindeiro P | 2005 | J Infect Dis2005，191，11： | 1 |
| 11 | Dy- namic task mapping for MPSoCs 显示文摘 | CARVALHO E CALAZANS N MORAES F | 2010 | IEEE Design and Test of Computers2010，27，5： | 1 |
| 12 | Comparison of network-on-chip mapping algorithms targeting low energy consumption显示文摘 | Marcon C A M Moreno E I Calazans N L V | 2008 | Computers & Dig- ital Techniques2008，2，6： | 1 |
| 13 | Physical activity and emotions in a period of social distancing due to the COVID-19 pandemic显示文摘Social distancing(SD)to prevent SARS-CoV-2(COVID-19)transmission reduced practices of physical activities(PA)and changed emotional conditions,but the relationship between PA and the emotions has to be further studied.This study aimed to analyze PA and the intensity of basic emotions during a period of social distancing in the State of S~ao Paulo,Brazil.Data collection was performed using the snowball system and an online survey with questions about the minimum weekly frequency of 30-min moderate and/or vigorous activities(MVPA),intensity of basic emotions,and sociodemographic profile.A total of 704 volunteers participated;mean age 38.113.4 years,67.9%female,82.0%insufficiently practiced MVPA,and 37.9%of the group reported no weekly PA.Anxiety/fear was the emotion with the highest intensity in the study period.A significant association was observed between PA and intensity of happiness(rho=0.125;p<0.01)and a negative association between PA practice and intensity of anxiety/fear(rho=-0.090;p<0.05),sadness(rho=-0.134;p<0.01),and anger(rho?0.109;p<0.01).Also,an association was observed between anxiety/fear and social isolation(rho=0.082;p<0.05).These results suggest that public policies offering PA programs and psychological care are required to improve the quality of life of the population. | Raphaela Espanha Corrêa Paulo Eduardo Neves Ferreira Velho Rafael do Prado Calazans Calvino Camargo Rute Estanislava Tolocka | 2022 | Sports Medicine and Health Science2022，4，3： | 0 |
| 14 | Simulated rainfall in Brazil:An alternative for assesment of soil surface processes and an opportunity for technological development显示文摘Rainfall simulators(RS)have been used,above all,to evaluate hydrological processes related to soil water infiltration,surface runoff and soil erosion.They allow repeatability of rain application with different precipitation intensities in field and/or laboratory conditions and should produce events with physical characteristics similar to natural rain.In this manuscript,we carried out a bibliometric and scientometric analysis of studies with simulated rainfall in Brazil to assess the temporal evolution of publications,the main topics addressed and the degree of technological development of the equipment.We searched for the terms“rainfall simulator”OR“simulated rainfall”AND“Brazil”in the Scopus,Web of Science,SciELO and Google Scholar databases.We found 143 articles published in the last 37 years(1985-2022).Our findings indicate that the main research areas covered in papers are soil erosion(57.34%),soil water infiltration(24.47%),nutrient losses(9.8%)and RS development and calibration/assessment(8.39%).In recent years,the number of published papers in international high-impact factor journals has increased.Most of the papers(49.65%)refer to studies carried out by institutions located in the south and southeast regions of Brazil.Moreover,there is a large gap of studies on simulated rainfall in other regions of Brazil,where important biomes such as the Cerrado,Amazon,Caatinga,and their transitions are located.This study informs research priorities on soil erosion under simulated rainfall and provides a bibliographic database that can assist in more detailed future analyses. | Camila Calazans da Silva Luz Wilk Sampaio de Almeida Adilson Pacheco de Souza Nivaldo Schultz Jamil Alexandre Ayach Anache Daniel Fonseca de Carvalho | 2024 | International Soil and Water Conservation Research2024，12，1： | 0 |
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