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您的检索式：作者名="Caiting Deng"
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| 1 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 2 | Biomaterial-assisted photoimmunotherapy for synergistic suppression of cancer progression显示文摘Photoimmunotherapy is an emerging treatment modality that uses photothermal,photodynamic and photochemical processes to fight against cancer by eliciting a robust host immune response.Recently,various nanoformulations of biomaterials have been rationally designed as highly effective photosensitive agents,immunoadjuvants or carriers to enhance phototherapeutic efficacy,boost immune stimulation,amplify nano-permeability and monitor cancer progression in situ.Nevertheless,relying solely on a single-modality therapy may not completely ablate primary tumors,and the metastasis and recurrence of tumors remain a serious challenge.To solve this issue,the strategy of combining photoimmunotherapy with other immunotherapies,such as immune checkpoint blockade,chimeric antigen receptor-T cell or cytokine therapy,can greatly enhance the effectiveness of oncology treatment and reduce the traditional adverse effects.Thus,it is very valuable to summarize the research progress in biomaterial-assisted combination photoimmunotherapy for clinical translation.In this review,the recent advances in constructing multifunctional nano-biomaterials for combinatorial photoimmunotherapy of cancer are summarized.Furthermore,the opportunities,challenges,future trends and prospects in this field are also analyzed to pave the way for advancing the next generation of clinical cancer management strategies. | Yanan Li Jing Cui Chenlong Li Caiting Deng Guowei Deng Hui Zhang Feifei An | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
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